Peripheral nerve sheath tumor (neurofibrosarcoma)
Research & Innovation
What is the latest research on soft tissue sarcomas?
A variety of chemotherapeutic regimens have been evaluated in the treatment of newly diagnosed high-grade gliomas.
- While studies in adults have suggested that procarbazine, vincristine and CCNU (PVC) produce modest responses in grade III gliomas, this has not been demonstrated for pediatric cases or for grade IV tumors.
- Several other regimens have also produced responses, but none has improved survival.
- Increased doses of chemotherapy in the setting of autologous bone marrow transplant have also not produced notable advantage.
We are conducting numerous research studies that will help clinicians better understand and treat soft tissue sarcomas. Types of treatment currently being studied include:
- angiogenesis inhibitors- substances that may be able to prevent the growth of tumors by blocking the formation of new blood vessels that feed the tumors
- biological therapies- a wide range of substances that may be able to involve your child’s own immune system to fight cancer or lessen harmful side effects of some treatments
What is the latest research on neurofibrosarcoma?
Scientists at Boston Children's Hospital and Dana-Farber Cancer Institute are conducting numerous research studies that will help clinicians better understand soft tissue tumors.
There are many ways in which your child might benefit from our medical research program. Our doctors and scientists have made many breakthrough discoveries about diseases like polio and leukemia; our ongoing innovative research continues to push the boundaries of the way pediatric medicine is practiced.
It’s possible that your child will be eligible to participate in one of our current clinical trials. These studies are useful for a multitude of reasons:
Some trials are designed to evaluate the effectiveness of a particular drug, treatment or therapy on a specific disease; others help doctors to better understand how and why certain conditions occur. At any given time,
We have hundreds of clinical trials underway. Of course, your motives as a parent needn’t be entirely altruistic—you’ll naturally want to know how taking part in a trial can immediately benefit your child. If your child’s physician recommends participation in one of Children’s clinical trials, that likely means that your child’s physician believes that the plan outlined in that trial represents the absolute best, latest care your child can possibly receive.
And participation in any clinical trial is completely voluntary: We will take care to fully explain all elements of the treatment plan prior to the start of the trial, and you may remove your child from the medical study at any time.
To search for a cancer trial at Dana Farber/Children’s Hospital Cancer Center, go to:
http://www.dana-farber.org/Apps/clinical_trials/search.aspx (under Pediatric).
To search the NIH’s list of clinical trials taking place around the world, go to: http://www.clinicaltrials.gov/ct2/search