Research & Innovation
At Children’s Hospital Boston, we’re known for our science-driven approach and our intense culture of innovation—a philosophy that pushes the boundaries of pediatric care. We’re frequently ranked as one of the top pediatric hospitals in the United States.
Doctors at Children’s currently understand most of what they need to know to effectively treat conditions like Addison’s disease. The focus now is on finding the next generation of therapies.
A history of treatment
There’s a long history at Children’s of treating conditions like Addison’s disease. In fact, John Crigler, MD—the founding chief of Children’s Division of Endocrinology—pioneered the use of glucocorticoids in the 1950s to treat patients with adrenal insufficiency. Today, Children’s physicians are building on that legacy through research and increased understanding of the best way to treat these conditions.
David Breault, MD, PhD, a pediatric endocrinologist at Children’s, is developing cell-based therapies using stem cell technology to optimize the replacement of missing hormones that cause conditions like Addison’s disease. His research includes searching for tissue stem cells within the adrenal gland itself that may be useful for treating adrenal insufficiency, or potentially using embryonic stem cells that may one day be converted into steroid-producing cells.
Learn more about research at Children's.
Search our list of clinical trials.