Research & Innovation
A hopeful future
Treatment for brain tumors in children has progressed tremendously in the last decade:
New tools are being used to help doctors diagnose tumors sooner and with more accuracy.
Radiation therapy and chemotherapy are increasingly targeting tumors more accurately and effectively while keeping clear of healthy brain cells and tissue.
- A successful new surgical technique is the intra-operative MRI, which gives surgeons a three-dimensional picture of the tumor so they can remove the cancer while leaving other parts of the brain relatively untouched.
A urine test for brain tumors?
A urine sample can tell you many things. It can reveal pregnancy, signal an infection or unmask drug use. Could a urine sample also tell you about brain tumors? Maybe.
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Now recruiting: Clinical trial for children with
supratenorial malignant glioma
The use of immunotherapy, especially when combined with standard therapies, is a promising area in the treatment of malignant gliomas in adults. This approach has yielded encouraging clinical results in improving outcomes from surgery, radiation and chemotherapy.
Dana-Farber/Children's Hospital Cancer Center is now investigating this treatment avenue for children. and has recently opened an immunotherapy-based gene therapy Phase I clinical trial for children with a supratenorial malignant glioma.
Who is eligible?
Patients between the ages of 3 and 22 with newly diagnosed supratenorial malignant glioma
Learn more about the study
|Gene mutations explain medulloblastoma behavior|
Why do medulloblastomas behave so differently from child to child? Boston Children's Neurologist-in-Chief Scott Pomeroy, MD, PhD, may have the answer: a set of gene mutations that essentially divide this tumor (the most common malignant childhood brain tumor) into four separate diseases. Learn more.
|Brain tumors and cerebrospinal fluid|
Christopher Walsh, MD, PhD, chief of the Division of Genetics at Children's found proteins in cerebrospinal fluid (CSF) that are associated with a type of brain tumor called glioblastoma. They found that Pals1 protein and Pten protein affect how stem cells grow and divide in the brain, and a disruption in these proteins may be connected to brain tumors. Learn more about this research in the Children’s newsroom.