Isaac Kohane, MD, PhD

Department	Endocrinology
Hospital Title	Chair, Informatics Program
Academic Title	Lawrence J. Henderson Professor of Pediatrics and Health Sciences and Technology
Phone	617-919-2184
Fax	617 730-0921
Email	Isaac Kohane
Location	300 Longwood Avenue Enders-6 Boston MA 02115

Research Overview

Isaac (Zak) Kohane is the director of the Children's Hospital Informatics Program and is the Henderson Professor of Pediatrics and Health Sciences and Technology at Harvard Medical School (HMS). He is also co-director of the HMS Center for Biomedical Informatics and Director of the HMS Countway Library of Medicine. Dr. Kohane leads multiple collaborations at Harvard Medical School and its hospital affiliates in the use of genomics and computer science to study cancer and the development of the brain (with emphasis on autism). He has developed several computer systems to allow multiple hospital systems to be used as "living laboratories" to study the genetic basis of disease while preserving patient privacy. Dr. Kohane's research builds on his doctoral work in computer science on decision-support and subsequent research in machine-learning applied to biomedicine. Dr. Kohane has led the development of cryptographic health identification systems, automated personal health records and peer-to-peer pathology information networks. Dr. Kohane leads several NIH-funded efforts to translate genomic research into clinical practice and continues his own practice in pediatric endocrinology at Children's Hospital Boston.

About Isaac Kohane

Isaac Kohane received his MD from Boston University School of Medicine. He completed an internship, residency, and fellowship at Children's Hospital Boston.

Dr. Kohane is a founder of the Center for Outcomes and Policy Research at the Dana-Farber Cancer Institute, founder and Associate Director for the Center for Genetic Epidemiology at Harvard Medical School. He is a Fellow of the American College of Medical Informatics and of the Society for Pediatric Research.

Key Publications

• Butte, A. J., Tamayo, P., Slonim, D., Golub, T. R., and Kohane, I. S. (2000). Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc Natl Acad Sci U S A 97, 12182-12186.
   
• Kho, A. T., Zhao, Q., Cai, Z., Butte, A. J., Kim, J. Y., Pomeroy, S. L., Rowitch, D. H., and Kohane, I. S. (2004). Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev 18, 629-640.
   
• Simons, W. W., Mandl, K. D., and Kohane, I. S. (2005). The PING personally controlled electronic medical record system: technical architecture. J Am Med Inform Assoc 12, 47-54.
   
• Butte, A. J., and Kohane, I. S. (2006). Creation and implications of a phenome-genome network. Nat Biotechnol 24, 55-62.
   
• Kohane, I. S., Masys, D. R., and Altman, R. B. (2006). The incidentalome: a threat to genomic medicine. Jama 296, 212-215.
   
• Kohane, I. S., Mandl, K. D., Taylor, P. L., Holm, I. A., Nigrin, D. J., and Kunkel, L. M. (2007). Medicine. Reestablishing the researcher-patient compact. Science 316, 836-837.