Irina Anselm, MD
|Hospital Title||Assistant in Neurology|
|Academic Title||Assistant Professor of Neurology|
300 Longwood Avenue
Boston MA 02115
We study mitochondrial disorders, a large group of chronic disorders affecting mitochondria, the cellular machines that produce energy throughout the body. Our research is focused on the clinical presentation of children with mitochondrial disorders and their response to therapy with different medications and vitamins/supplements.
Currently I am a principal investigator in a study examining the ability of the drug dichloroacetate (DCA) to treat children with mitochondrial disorders complicated by lactic acidemia, a condition in which excess lactate builds up in the blood and spinal fluid. DCA reduces lactate levels and thus has the potential to alleviate disease symptoms. I evaluate children in clinic, enroll them in the protocol and follow them in the Mitochondrial Program while they are being maintained on DCA.
About Irina Anselm
Irina Anselm received her MD from St. Petersburg Pediatric Medical Academy. She completed an internship and residency in pediatrics at UMASS Medical Center and a fellowship in child neurology at Floating Hospital for Children at the New England Medical Center.
- Parikh S, Saneto R, Falk MJ, Anselm I, Cohen BH, Haas R, Medicine Society TM. A modern approach to the treatment of mitochondrial disease. Curr Treat Options Neurol 2009 Nov; 11(6):414-30.
- Anselm IA, Sweadner KJ, Gollamudi S, Ozelius LJ, Darras BT. Rapid-onset dystonia-parkinsonism in a child with a novel atp1a3 gene mutation. Neurology 2009 Aug 4; 73(5):400-1.
- Anselm IA, Coulter DL, Darras BT. Cardiac manifestations in a child with a novel mutation in creatine transporter gene SLC6A8. Neurology 2008 Apr 29; 70(18):1642-4.
- Anselm IA, Darras BT. Re: Dichloroacetate causes toxic neuropathy in MELAS: A randomized, controlled clinical trial. Neurology 2006 Oct 10; 67(7):1313.
- Anselm IA, Darras BT. Catecholamine toxicity in aromatic L-amino acid decarboxylase deficiency. Pediatr Neurol 2006 Aug; 35(2):142-4.
- Anselm I, Alkuraya F, Salomons G, Marsden D. X-linked creatine transporter defect: report on two unrelated boys with a severe clinical phenotype. J Inherit Metab Dis 2006 Feb; 29(1):214-9.
For a list of Irina Anselm's publications on PubMed, click here.