Jordan Kreidberg, MD, PhD
|Hospital Title||Associate in Medicine|
|Academic Title||Associate Professor of Pediatrics|
300 Longwood Avenue
Boston MA 02115
Jordan Kreidberg's principal research goal is to understand the genetic mechanisms of organogenesis, with a focus on the urogenital system. More specifically, his lab seeks to:
- Understand the inductive mechanisms of early organ development.
- Define regulatory interactions that establish and maintain normal glomerular function and prevent chronic renal failure.
- Define the stem cell compartment of the developing kidney, and develop approaches for propagating the stem cell compartment.
If kidney stem cells can be defined and propagated, they may ultimately be used to regenerate new kidney tissue in individuals with chronic renal failure. Determining the regulatory interactions within the glomerulus could also yield treatments to reverse glomerular damage and prevent situations that lead to nephrotic syndrome and chronic renal failure.
The researchers have recently demonstrated a novel inductive interaction between angioblasts--the cells that give rise to blood vessels--and mesenchymal precursor cells--which differentiate into connective tissue--that is required for early kidney development. They are also determining how the integrin family of adhesion receptors participate in organogenesis and are examining how the Wt1 transcription factor and the alpha3 beta1 integrin receptor regulate glomerular development and maintain normal glomerular function.
About Jordan Kreidberg
Dr. Kreidberg received his MD and PhD from Johns Hopkins University School of Medicine. He completed his internship and at Children's Hospital Boston and a postdoctoral fellowship at the Whitehead Institute.
Natoli TA, Liu J, Eremina V, Hodgens K, Li C, Hamano Y, Mundel P, Kalluri R, Miner J, Quaggin S, Kreidberg JA. A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash Syndrome interferes with glomerular capillary development. Journal of the American Society of Nephrology 2002; 13: 2058-2067.
Chattopadhyay N, Wang Z, Ashman LK, Brady-Kalnay SM, Kreidberg JA, Alpha3 beta1 integrin: CD151, a component of the cadherin:catenin complex, regulates PTP expression and cell-cell adhesion Journal of Cell Biology 2003; 163: 1351-1362.
- Natoli TA, Alberta JA, Bortvin A, Taglienti M, Menke D, Loring J, Jaenisch R, Page D, Housman DE, and Kreidberg JA. WT1 is required cell-autonomously for the development of all gonadal cell lineages, including the germ cell to gonocyte transition. Developmental Biology 2004; 268: 429-40.