Dusica Bajic, MD, PhD
|Hospital Title||Principal Investigator|
|Academic Title||Instructor in Anesthesia|
300 Longwood Avenue
Boston MA 02115
Dusica Bajic, MD, PhD, joined Dr. Commons' research group and became faculty member following her fellowship training in Pediatric Anesthesiology at Children's Hospital Boston. She is now a proactive clinician scientist who created a key program using infant animal models to determine how morphine acts in the developing brain that is different from that in adult for which she has received funding from the prestigious Foundation for Anesthesia Education and Research (FAER; www.faer.org). Investigation of the supraspinal mechanisms of age-dependent development of opioid tolerance is crucial to better understand the actions of opioid medications in human infants and children during surgery, critical illness or cancer treatment. This is an important new area of research that may provide novel insights into molecular mechanisms of opioid tolerance that will lead to novel clinical therapies that differ with age.
About Dusica Bajic
Dr. Bajic received her MD from the Medical School of the University of Belgrade, Serbia and PhD from the Department of Pharmacology at the University of Illinois at Chicago, IL. Her postdoctoral training included: (1) Postdoctoral Fellow at the Department of Anatomy and Cell Biology at the University of Illinois at Chicago, (2) Anesthesia Residency training at Yale New Haven Hospital, Yale University, as well as (3) Pediatric Anesthesia Fellowship at Children's Hospital Boston, Harvard University where she now works as board certified staff anesthesiologist since 2008.
- Bajic, D. & Commons, K.G. (2010). Acute noxious stimulation increases morphine effect in subset of serotonergic and not dopaminergic midbrain areas. Neuroscience, 166(2): 720-729.
- Bajic, D. & Commons, K.G. (2010). Visualizing acute pain – morphine interaction in monoamine descending pain modulatory pathways with Fos. Brain Res. 1306: 29-38.
- Soriano, S.G., Liu, Q., Li, J., Liu, J-R., Han, X.H., Kanter, J.L., Bajic, D. & Ibla, J.C. (2010). Ketamine activates cell cycle signaling and apoptosis in the neonatal rat brain. Anesthesiology, 112: 1155-1163.
- Ibla, J.C., Hayashi, H., Bajic, D. & Soriano, S.G. (2009). Prolonged exposure to ketamine increases brain derived neurotrophic factor levels in developing rat brain. Curr. Drug Saf. 4: 11-16.
- Bajic, D., Hoang, Q.V., Nakajima, S. & Nakajima, Y. (2004). Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects. J. Neurosci. Method. 132: 177-184.
- Hoang, Q.V., Bajic, D., Yanagisawa, M., Nakajima, S. & Nakajima, Y. (2003). Effects of Orexin (Hypocretin) on GIRK channels. J. Neurophys. 90:693-702.
- Bajic, D., Koike, M., Albsoul-Younes, A.M., Nakajima, S. & Nakajima, Y. (2002). Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neurons. Proc. Nat. Acad. Sci. 99 (22) 14494-14499.
- Bajic, D., Van Bockstaele, E.J. & Proudfit, H.K. (2001). Ultrastructural analysis of ventrolateral periaqueductal gray projections to the A7 catecholamine cell group. Neuroscience 104 (1): 181-197.
- Van Bockstaele, E.J., Bajic, D., Proudfit, H.K. & Valentino, R. (2001). Topographic architecture of stress-related pathways targeting the noradrenergic locus coeruleus. Physiol. Behav. 73 (3): 273-283.
- Bajic, D., Proudfit, H.K. & Van Bockstaele, E.J. (2000). Periaqueductal gray neurons monosynaptically innervate extranuclear noradrenergic dendrites in the rat pericoerulear region. J. Comp. Neurol. 427 (4): 649-662.
- Bajic, D. & Proudfit, H.K. (1999). Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J. Comp. Neurol. 405 (3): 359-379.