Kristin Moffitt, MD
| Department | Infectious Diseases |
 |
| Hospital Title | Assistant in Medicine | |
| Academic Title | Instructor in Pediatrics | |
| Phone | 617-919-2900 | |
| Fax | 617-730-0255 | |
| Kristin Moffitt | ||
| Location |
300 Longwood Avenue Enders-8 Boston MA 02115 |
Research Overview
Dr. Moffitt’s research focuses on the development of newer generation bacterial vaccines, particularly to the common human pathogen, Streptococcus pneumoniae. Her work has identified several novel pneumococcal proteins that confer protection against colonization of the nasopharynx and may be candidate components of a pneumococcal protein subunit vaccine. To study these proteins, she is investigating their interaction with the host immune system. Dr. Moffitt’s work specifically explores the role of activation of the innate immune system in acquisition of protective immune responses. The overall goal of her research is to more clearly define the mechanisms of immunity to pneumococcus and to use these findings to guide the development of alternative bacterial vaccine strategies.
About Kristin Moffitt
Dr. Moffitt received her undergraduate degree at Wellesley College and her medical degree from University of Vermont College of Medicine. She completed her internship and residency training in pediatrics at Hasbro Children’s Hospital of Brown Medical School followed by fellowship in pediatric infectious diseases at Children’s Hospital Boston. She joined the faculty of the Division of Infectious Diseases at Children’s Hospital Boston in 2010.
Key Publications
- Moffitt K, Gierahn T, Lu Y, Gouveia P, Alderson P, Flechtner JB, Higgins D, Malley R. TH17 based vaccine design for prevention of Streptococcus pneumoniae colonization. Cell Host and Microbe, 9: 158-165, 2011. PMID: 21320698.
- Moffitt KL, Yadav P, Weinberger DM, Anderson PW, Malley R. Broad antibody and T cell reactivity induced by a pneumococcal whole-cell vaccine. Vaccine, 30: 4316-22, 2012. PMID: 22682288 .
- Moffitt KL and Malley R. Next generation pneumococcal vaccines. Current Opinion in Immunology, 23(2):407-13, 2011. PMID: 21514128
