Thomas Look, MD
| Department | Hematology/Oncology |
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| Hospital Title | Vice Chair for Research, Department of Pediatric Oncology | |
| Academic Title | Professor of Pediatrics | |
| Phone | 617-632-5826 | |
| Fax | 617-632-6989 | |
| Thomas Look | ||
| Location |
44 Binney Street ayer-6 Boston MA 02115 |
Research Overview
The ultimate goal of the Look group's studies is to reveal mutant genes, thus providing candidate targets for the development of new therapies. To this end it is exploring:
- Models of leukemogenesis,particularly the antiapoptotic transcriptional pathway downstream of E2A-HLF, a chimeric oncoprotein activated by chromosomal translocation in childhood leukemia.
- Developmental pathways subverted in human leukemias and solid tumors. They are conducting a genome-wide mutagenesis screen in zebrafish to identify genes required for normal myeloid cell development in the hematopoietic system.
- Pathways that lead to T-cell leukemia. They have shown that human T-cell leukemias can be divided into five major subtypes based on the expression of oncogenes that initiate malignant transformation in thymocytes and have overexpressed these oncogenes in zebrafish T-cell progenitors.
About Thomas Look
Thomas Look received his MD and completed an internship and residency in pediatrics at the University of Michigan. He subsequently completed his fellowship in pediatric oncology at St. Jude Childrens Research Hospital in Memphis.He was named Second Annual Lecturer in Leukemia at The Hospital for Sick Children, Toronto, Canada, 2000; Second Annual Giulio J. D'Angio Lecturer, University of Pennsylvania Cancer Center, 1999; and recieved an Award for Excellence in Pediatric Research, American Academy of Pediatrics, 1995.
Key Publications
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Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002;1:75-87.
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Inoue A, Seidel MG, Wu W, Kamizono S, Ferrando AA, Bronson RT, Iwasaki H, Akashi K, Morimoto A, Hitzler JK, Pestina TI, Jackson CW, Tanaka R, Chong MJ, McKinnon PJ, Inukai T, Grosveld GC, Look AT. Slug, a highly conserved zinc-finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2002;2:279-88.
- Langenau DM, Palomero T, Kanki JP, Ferrando AA, Zhou Y, Zon LI, Look AT. Molecular cloning and developmental expression of Tlx (Hox11) genes in zebrafish (Danio rerio). Mech Dev 2002;117:343-8.
