Scott B. Snapper, MD, PhD
|Hospital Title||Director of Inflammatory Bowel Disease Center|
|Academic Title||Associate Professor of Medicine, Harvard Medical School|
300 Longwood Avenue
Boston, MA 02115
The Snapper laboratory is interested in the mechanisms that control immune responses and function in the gastrointestinal tract as well as host-microbial interactions that, in turn, regulate immune homeostasis in the intestine.
To this end, we have employed several basic, translational, and clinical research strategies to understand and define not only the constituents but also the mechanisms that regulate intestinal homeostasis as it pertains to gastrointestinal health and disease with a primary focus on inflammatory bowel disease (IBD) and primary immunodeficiencies. A new ambitious clinical research endeavor is the Roadmap to Cure of Early Childhood IBD Project that is the focus of the InterNational Early Onset Pediatric IBD Cohort Study (NEOPICS).
About Scott Snapper
Dr. Snapper grew up Catskill, New York and did his undergraduate work at Tufts University in Boston where he graduated summa cum laude with a B.S. in Chemistry and Biology in 1983. In 1990 Scott received his M.D., Ph.D. from Albert Einstein College of Medicine and puarsued residency in Medicine at Brigham and Women’s Hospital (BWH), a clinical fellowship in Gastroenterology and Hepatology at Massachusetts General Hospital (MGH), and advanced immunology postdoctoral training at Harvard Medical School (HMS) in the laboratory of Frederick Alt, Dr. Snapper joined the faculty at MGH and HMS in 1997.
Dr. Snapper holds the Wolpow Family Chair and is the Director of the Center for Inflammatory Bowel Disease as well as Director of Basic and Translational Research. In addition, Dr. Snapper has become the Director of IBD Research within the Gastroenterology Division at BWH where he maintains a joint clinical appointment. Dr. Snapper is Associate Professor of Medicine at Harvard Medical School (HMS).
1. Cotta-de-Almeida V, Westerberg L, Maillard M, Onaldi D, Watchtel H, Meelu P,Chung U, Xavier R, Alt F, and Snapper SB. 2007. WASP and N-WASP are critical for T cell Development. PNAS 104: 15424-15429. PMID: 17878299
2. Nguyen D, Maillard M, Cotta-de-Almeida V, Mizoguchi E, Klein C, Fuss I, Nagler C, Mizoguchi A, Bhan AK, Snapper SB. 2007. Lymphocyte-Dependent and Th2 Cytokine-Associated Colitis in Mice Deficient in Wiskott-Aldrich Syndrome Protein. Gastroenterology 133:1188–1197. PMID: 17764675
3. Glocker E.O. et al., 2009. Early-onset inflammatory bowel disease caused by loss-of-function mutations in the IL10-receptor genes.” N. Engl. J. Med. 361(21): 2033-45. PMID: 19890111.
4. Lyubimova A, Garber J, Upadhyay G, Anastasoaie F, Yajnik V, Cotsarelis G, Dotto GP, Botchkarev V, Snapper SB. 2010. N-WASP Regulates WNT Signaling and is Required for Hair Follicle Cycling. Journal of Clinical Investigation 120(2): 446-56. PMID: 20071778.
5. Moran CJ, Guo C-H, Kugathasan S, Klein C, Wolters VM, Walters TD, NEOPICS, Bandsma RH, Mouzaki M, Langer JC, Cutz E, Benseler SM, Chaim M Roifman CM, Silverberg MS, Griffiths AM, Snapper SB, Muise AM. 2012. IL-10R Polymorphisms are Associated with Very Early-Onset Ulcerative Colitis. IBD Journal. (in press)