Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

Princeton University

1982, Princeton, NJ

Medical School

Harvard Medical School

1987, Boston, MA

Internship

Massachusetts General Hospital

1988, Boston, MA

Residency

Radiology

Massachusetts General Hospital

1989, Boston, MA

Residency

Massachusetts General Hospital

1991, Boston, MA

Fellowship

Massachusetts General Hospital

1994, Boston, MA

Graduate School

Medical Science in Clinical Investigation

Harvard Medical School

1997, Boston, MA

Certifications

  • American Board of Internal Medicine (Cardiovascular Disease)

Publications

  1. Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity. Nat Aging. 2022 08; 2(8):714-725. View Abstract

  2. Nature Aging. Landscape of Somatic Mutations in Aging Heart Muscle Cells. 2022; (2). View Abstract

  3. Prognostic Value of Exercise Stress Echocardiography in Pediatric Cardiac Transplant Recipients. J Am Soc Echocardiogr. 2022 11; 35(11):1133-1138.e2. View Abstract

  4. American Heart Association Scientific Sessions. Polyvalvular Heart Disease in Children Associated with FilaminA Mutations. 2021.

  5. American Heart Association Scientific Sessions. Prevalence of Isolated Nocturnal Hypertension in Adolescents with Use of Adult Hypertension Criteria. 2021.

  6. Chen and De Ferranti are joint senior authors. American Heart Association Scientific Sessions. Impact of standard interventions for dyslipidemia and elevated blood pressure in childhood cancer survivors. 2021.

  7. American Heart Association Scientific Sessions. Left Atrial Size and Function in Children and Young Adults with Obstructive vs. Nonobstructive Hypertrophic Cardiomyopathy. 2021.

  8. American Heart Association Scientific Sessions. Somatic Mutations in Single Human Cardiomyocytes Reveal Rapid Age-Related DNA Damage and Cardiomyocyte Fusion. 2021.

  9. American Heart Association Scientific Sessions. Exercise Induced Pulmonary Hypertension in Long Term Survivors of Congenital Diaphragmatic Hernia. 2021.

  10. Déjà Vu: Recurrent Sudden Cardiac Arrests in a Child With an Anomalous Left Coronary Artery. JACC Case Rep. 2021 Oct 06; 3(13):1527-1530. View Abstract

  11. International Society of Pediatric Oncology Annual Scientific Meeting. Survivors of Pediatric Hematopoietic Stem Cell Transplant Develop Diastolic Dysfunction with Increasing Years of follow-up. 2021.

  12. Radiation-Associated Coronary Disease in Young Cancer Survivors: The Beat Goes On; We Must Preserve It. JACC CardioOncol. 2021 Sep; 3(3):393-396. View Abstract

  13. Coronary artery disease surveillance among childhood, adolescent, and young adult cancer survivors: a systematic review and recommendations from the International Late Effects of Childhood Caner Guideline Harmonization Group. 2021.

  14. Vo2peak in Adult Survivors of Hodgkin Lymphoma: Rate of Decline, Sex Differences, and Cardiovascular Events. J Am Coll Cardiol CardioOnc. 2021; 2(3):263-273. View Abstract

  15. American College of Cardiology, Scientific Sessions. Diastolic Dysfunction in Long-term Bone Marrow Transplant Recipients. 2021.

  16. Clinical Syndromic Phenotypes and the Potential Role of Genetics in Pulmonary Vein Stenosis. Children (Basel). 2021 Feb 10; 8(2). View Abstract

  17. Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21. Children (Basel). 2021 Jan 01; 8(1). View Abstract

  18. Doxorubicin and subsequent risk of cardiovascular diseases among survivors of diffuse large B-cell lymphoma in Hong Kong. Blood Adv. 2020 10 27; 4(20):5107-5117. View Abstract

  19. American Society of Echocardiography, Scientific Sessions. What is the value of stress echo for patients with a negative angiogram?. 2020.

  20. Value of Exercise Stress Echocardiography in Children with Hypertrophic Cardiomyopathy. J Am Soc Echocardiogr. 2020 07; 33(7):888-894.e2. View Abstract

  21. American College of Cardiology, Scientific Sessions. Prognostic Value of Exercise Stress Echocardiography in Pediatric Cardiac Transplant Recipients. 2020.

  22. Guidelines for Performance, Interpretation, and Application of Stress Echocardiography in Ischemic Heart Disease: From the American Society of Echocardiography. J Am Soc Echocardiogr. 2020 01; 33(1):1-41.e8. View Abstract

  23. The landscape of cardiovascular care in pediatric cancer patients and survivors: a survey by the ACC Pediatric Cardio-Oncology Work Group. Cardiooncology. 2019; 5:16. View Abstract

  24. International Academy of Cardiology, 23rd World Congress of Heart Disease. Congenital Heart Disease in Patients with Loss of Function FilaminA mutations: Genotype-Phenotype Correlations. 2018.

  25. American Society of Echocardiolgraphy. Structural Cardiac Anomalies in LOF FilaminA mutation patients: the Role of Echocardiography. 2018.

  26. American Society of Clinical Oncology. Modeling Risk of Heart Failure in Survivors of Childhood Cancer: early results from the pediatric normal tissue effects in the Clinic Group (PENTEC). 2018.

  27. De novo and inherited private variants in MAP1B in periventricular nodular heterotopia. PLoS Genet. 2018 05; 14(5):e1007281. View Abstract

  28. Thoracic aortic aneurysm in patients with loss of function Filamin A mutations: Clinical characterization, genetics, and recommendations. Am J Med Genet A. 2018 02; 176(2):337-350. View Abstract

  29. Rationale and design of the Children's Oncology Group (COG) study ALTE1621: a randomized, placebo-controlled trial to determine if low-dose carvedilol can prevent anthracycline-related left ventricular remodeling in childhood cancer survivors at high risk for developing heart failure. BMC Cardiovasc Disord. 2016 10 04; 16(1):187. View Abstract

  30. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 2016 Aug 25; 166(5):1147-1162.e15. View Abstract

  31. Howard Hughes Medical Student Conference. Tissue Specific Intron Retention is a New Mechanism for FLNA mutation. 2016.

  32. Exercise Performance in Patients with D-Loop Transposition of the Great Arteries After Arterial Switch Operation: Long-Term Outcomes and Longitudinal Assessment. Pediatr Cardiol. 2016 Feb; 37(2):283-9. View Abstract

  33. FLNA-Related Periventricular Nodular Heterotopia. GeneReviews. 2015.

  34. Prospective assessment of deep inspiration breath-hold using 3-dimensional surface tracking for irradiation of left-sided breast cancer. Pract Radiat Oncol. 2015 Nov-Dec; 5(6):358-65. View Abstract

  35. Cardiovascular Health of Patients With Cancer and Cancer Survivors: A Roadmap to the Next Level. J Am Coll Cardiol. 2015 Jun 30; 65(25):2739-46. View Abstract

  36. Recommendations for cardiomyopathy surveillance for survivors of childhood cancer: a report from the International Late Effects of Childhood Cancer Guideline Harmonization Group. Lancet Oncol. 2015 Mar; 16(3):e123-36. View Abstract

  37. American College of Cardiology. Longitudinal Exercise Performance in Patients with D-loop Transposition of the Great Arteries after Arterial Switch Operation. 2015.

  38. Effects of transcatheter pulmonary valve replacement on the hemodynamic and ventricular response to exercise in patients with obstructed right ventricle-to-pulmonary artery conduits. JACC Cardiovasc Interv. 2014 May; 7(5):530-42. View Abstract

  39. Blood pressure is associated with occult cardiovascular disease in prospectively studied Hodgkin lymphoma survivors after chest radiation. Leuk Lymphoma. 2014 Nov; 55(11):2477-83. View Abstract

  40. American College of Cardiology. Clinical and Genetic Features of pulmonary vein stenosis. 2014.

  41. ALERT—Adverse Late Effects of Cancer Treatment, Volume 2: Specific Normal Tissue Sites. Heart, Coronary Arteries, Aorta and Great Vessels, Arteries and Veins, Microcirculation. 2013.

  42. Cardiac allograft function during the first year after transplantation in rejection-free children and young adults. Circ Cardiovasc Imaging. 2012 Nov; 5(6):756-64. View Abstract

  43. Exercise stress echocardiographic assessment of outflow tract and ventricular function in patients with an obstructed right ventricular-to-pulmonary artery conduit after repair of conotruncal heart defects. Am J Cardiol. 2012 Nov 15; 110(10):1527-33. View Abstract

  44. Utility of exercise stress echocardiography in pediatric cardiac transplant recipients: a single-center experience. J Heart Lung Transplant. 2012 May; 31(5):517-23. View Abstract

  45. Management of cardiac toxicity in patients receiving vascular endothelial growth factor signaling pathway inhibitors. Am Heart J. 2012 Feb; 163(2):156-63. View Abstract

  46. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. Cardiotoxicity of Anti-cancer Therapeutics. 2012.

  47. Children's Oncology Group. Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. 2012.

  48. Cardiovascular disease: cause of morbidity and mortality in adult survivors of childhood cancers. Circ Res. 2011 Mar 04; 108(5):619-28. View Abstract

  49. Changes in echocardiographic measures of systolic and diastolic function in children 1 year after hematopoietic SCT. Bone Marrow Transplant. 2011 Dec; 46(12):1532-9. View Abstract

  50. Cardiac Co-Morbidity Boards: Cardiotoxicity of Tyrosine Kinase Inhibitors. ASCO CME Teaching Series 2011. 2011. View Abstract

  51. Late cardiovascular effects of anthracycline in childhood cancer survivors: Interview with the Expert: Dr. Ming Hui Chen. Fudan Journal of Pediatrics. 2010.

  52. Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation. Blood. 2011 Jan 13; 117(2):412-8. View Abstract

  53. Molecular target modulation, imaging, and clinical evaluation of gastrointestinal stromal tumor patients treated with sunitinib malate after imatinib failure. Clin Cancer Res. 2009 Sep 15; 15(18):5902-9. View Abstract

  54. Cardiac dysfunction induced by novel targeted anticancer therapy: an emerging issue. Curr Cardiol Rep. 2009 May; 11(3):167-74. View Abstract

  55. Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase. Clin Transl Sci. 2009 Feb; 2(1):15-25. View Abstract

  56. Mechanisms of cardiac dysfunction associated with tyrosine kinase inhibitor cancer therapeutics. Circulation. 2008 Jul 01; 118(1):84-95. View Abstract

  57. Cardiotoxicity of the tyrosine kinase inhibitor- sunitinib. Lancet. 2008.

  58. Monitoring for cardiovascular disease in survivors of childhood cancer: report from the Cardiovascular Disease Task Force of the Children's Oncology Group. Pediatrics. 2008 Feb; 121(2):e387-96. View Abstract

  59. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. Cardiotoxicity of Anti-Cancer Therapeutics. 2008.

  60. Children's Oncology Group. Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. 2008.

  61. Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet. 2007 Dec 15; 370(9604):2011-9. View Abstract

  62. Encephalopathy, stroke and myocardial infarction as complications of dimethyl sulfoxide use in stem cell transplantation. Neurology. 2007; 68:859-861..

  63. Stress Echocardiography: Indications and Protocols. Essential Echocardiography; a Practical Handbook with DVD (solomon and bulwer). 2007; 149-160.

  64. Filamin A is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Nat Acad Sci. 2006; 103(52):19836-19841..

  65. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med. 2006 Nov 07; 145(9):660-4. View Abstract

  66. Cardiac irradiation during mediastinal radiation for Hodgkin’s Disease. NCI Conference for Cancer Survivors. 2006.

  67. Primary hypothyroidism is a common complication of sunitinib therapy in patients with gastrointestinal stromal tumors. Ann Int Med. 2006; 145(9):660-664..

  68. Atrial endocarditis--the importance of the regurgitant jet lesion. Echocardiography. 2005 May; 22(5):426-30. View Abstract

  69. FLNA mutations cause a variant Ehlers-Danlos syndrome associated with periventricular heterotopia. Neurology 2005;64(2)254-62. Neurology. 2005; 64(2):254-262.

  70. Echoquest. 2003.

  71. Incidence and prognosis of syncope. N Engl J Med. 2002 Sep 19; 347(12):878-85. View Abstract

  72. Respiratory maneuvers decrease irradiated cardiac volume in patients with left-sided breast cancer. J Mag Reson Imag. 2002; 4(2):265-271.

  73. Post-surgical left ventricular pseudoaneurysm. Texas Heart Institute Journal. 2002; 29(3):220-21.

  74. Cardiac effects of propofol for transesophageal-guided cardioversion. Heart Dis. 2002; 4(6):355-7.

  75. Cardiac Ultrasound Curriculum for First Year Cardiac Fellows (Brigham and Women's Hospital). 2001.

  76. Reduction of cardiac volume in left-breast treatment fields by respiratory maneuvers: a CT study. Int J Radiat Oncol Biol Phys. 2000 Jul 01; 47(4):895-904. View Abstract

  77. Risk factors for syncope in a community-based sample (the Framingham Heart Study). Am J Cardiol. 2000 May 15; 85(10):1189-93. View Abstract

  78. Integration of Managed Care into Clinical Practice. 2000.

  79. Hypertrophic remodeling: gender differences in the early response to left ventricular pressure overload. J Am Coll Cardiol. 1998 Oct; 32(4):1118-25. View Abstract

  80. Impact of respiratory maneuvers on cardiac volume within left-breast radiation portals. Circulation. 1997 Nov 18; 96(10):3269-72. View Abstract

  81. Antecedent hypertension confers increased risk for adverse outcomes after initial myocardial infarction. Hypertension. 1997 Nov; 30(5):1020-4. View Abstract

  82. Echocardiographic assessment of mitral stenosis and its associated valvular lesions in 205 patients and lack of association with mitral valve prolapse. J Am Soc Echocardiogr. 1997 Mar; 10(2):141-8. View Abstract

  83. Prospective adaptive navigator correction for breath-hold MR coronary angiography. Magn Reson Med. 1997 Jan; 37(1):148-52. View Abstract

  84. Adaptive correction of imaging plane position in segmented K-space cine cardiac MR imaging. J Mag Reson Imag. 1997; Magn Res Med 37:811-814.

  85. Magnetic resonance coronary angiography during free breathing: comparison of navigator locations and respiratory suppression methods. Am J Roentgenol. 1997; 168:1369-1375.

  86. Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography. J Am Coll Cardiol. 1996 Dec; 28(7):1866-76. View Abstract

  87. Intracardiac echocardiography: in vitro and in vivo validation for right ventricular volume and function. Am Heart J. 1996 Feb; 131(2):320-8. View Abstract

  88. Incremental doses of dobutamine induce a biphasic response in dysfunctional left ventricular regions subtending coronary stenoses. Circulation. 1995 Aug 15; 92(4):756-66. View Abstract

  89. Intracardiac ultrasonographic assessment of atrial septal defect area: in vitro validation and technical considerations. Am Heart J. 1995 Aug; 130(2):302-6. View Abstract

  90. Pulsatile pressure affects the velocity of decay of echocardiographic contrast agents. J Am Soc Echocardiogr. 1995; 8:285-292..

  91. Intracardiac ultrasound measurement of volumes and ejection fraction in normal, infarcted, and aneurysmal left ventricles using a 10-MHz ultrasound catheter. Circulation. 1994 Sep; 90(3):1481-91. View Abstract

  92. Gender differences in clinical markers and dipyridimole-thallium imaging in the prediction of perioperative and long-term cardiac events after vascular surgery. Circulation. 1994; 91:1044-1051..

  93. Echo-doppler assessment of prosthetic heart valves: what is the meaning for the clinician?. ACC Curr. Jour. Rev. 1994; (Nov-Dec).

  94. FLNA-Related Periventricular Nodular Heterotopia. GeneReviews®. 1993. View Abstract

  95. Transfer function analysis of the circulation: unique insights into cardiovascular regulation. Am J Physiol. 1991 Oct; 261(4 Pt 2):H1231-45. View Abstract

  96. Transfer function analysis of the autonomic response to respiratory activity druing random interval breathing: II. Respiratory sinus arrhythmia. Am. J. Physiol. 1989; 25:H153-H161..

  97. Transfer function analysis of the autonomic response to respiratory activity during random interval breathing. Comput Cardiol. 1987; 13:149-52. View Abstract

  98. Method and Apparatus for the Assessment of Autonomic Response by Broad-band Excitation. 1986.

  99. Folate deficiency in chronic inflammatory bowel diseases. Scand J Gastroenterol. 1979; 14(8):1019-24. View Abstract

  100. Maintenance antipsychotic therapy: is the cure worse than the disease? Am J Psychiatry. 1976 Jan; 133(1):32-6. View Abstract

  101. Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH. Biochem Biophys Res Commun. 1975 Dec 15; 67(4):1527-36. View Abstract

  102. A comparison of the substrate specificities of endo-beta-N-acetylglucosaminidases from Streptomyces griseus and Diplococcus Pneumoniae. Biochem Biophys Res Commun. 1975 Nov 03; 67(1):455-62. View Abstract

  103. Studies of oxygen binding energy to hemoglobin molecule. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1424-31. View Abstract

  104. Atomic models for the polypeptide backbones of myohemerythrin and hemerythrin. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1349-56. View Abstract

  105. Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution. Biochem Biophys Res Commun. 1975 Oct 27; 66(4):1173-9. View Abstract

  106. [Biochemical studies on camomile components/III. In vitro studies about the antipeptic activity of (--)-alpha-bisabolol (author's transl)]. Arzneimittelforschung. 1975 Sep; 25(9):1352-4. View Abstract

  107. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. View Abstract

  108. [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a N-(2-cyanoethylene)-urea. Novel prophylactic possibilities]. Arzneimittelforschung. 1975 Sep; 25(9):1369-79. View Abstract

  109. Comparison between procaine and isocarboxazid metabolism in vitro by a liver microsomal amidase-esterase. Biochem Pharmacol. 1975 Aug 15; 24(16):1517-21. View Abstract

  110. The binding of substrates and inhibitors to dihydrofolate reductase. Biochem Soc Trans. 1975; 3(5):630-1. View Abstract

  111. 5-Carbamoylmethyluridine: a new minor nucleoside of transfer ribonucleic acid. Biochem Soc Trans. 1975; 3(5):656-9. View Abstract
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