Boston Children's Research

Research faculty

Research at Boston Children's Hospital

The research enterprise at Boston Children’s Hospital, comprising more than 3,000 researchers, is the world’s largest at a pediatric center. Our work is fueled by a deep understanding of disease biology coupled with world-class discovery platforms, including genetics and genomics, gene editing, bioinformatics, proteomics, bioengineering, image analysis, biobanks, disease-specific stem cell lines, and a range of animal models. We have special expertise in rare disease discovery, a robust Translational Research Program and large, diverse patient populations for clinical research and trials.

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Epstein-Barr virus EBV, best known as the virus behind mono, has been linked to various autoimmune disorders later in life, including lupus, multiple sclerosis, and rheumatoid arthritis. Now, a meticulous study led by Scott Snapper in our Inflammatory Bowel Disease Center, with fellow Anubhab Nandy, PhD, adds Crohn’s disease to the list — and...

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All living cells require a continuous supply of oxygen to maintain structure and function. Even brief episodes that compromise oxygen supply can lead to significant disability and death. John Kheir and Yifeng Peng have developed a potential treatment that allows the direct injection of oxygen gas into the bloodstream to rescue patients in these life-threatening situation...

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Last week four of our rare disease experts - Mira Bjelotomich Irons, MD, Christine Duncan, MD, Jennifer Arnold, MD, MSc, and Timothy Yu, MD, PhD - participated in the Boston Globe Media's 2025 Rare Disease Summit. Watch recordings of their sessions and hear how they're driving meaningful change in the rare disease space: http://ms.spr.ly/6049q1BA7

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We are proud to be part of the International Precision Child Health Partnership IPCHiP, an international effort to accelerate discovery and improve outcomes in rare pediatric disease. Learn more about IPCHiP, its partnering children's hospitals Boston Children's, The Hospital for Sick Children, Murdoch Children's Research Institute MCRI, UCL Great Ormond Street Institute for Child ...

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A study in Cell led by Ryan Flynn extends his previous discovery of glycoRNAs as new players on the cell surface. It defines a new kind of cell-surface domain containing highly organized clusters of glycoRNAs and RNA-binding proteins, together gating entry of outside factors into cells. Flynn and his colleagues see these clusters as a new “organelle” for ...

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Managing type 1 diabetes can be overwhelming for kids and families. Many cut back on nutritionist visits, while others face food insecurity, making it hard to maintain a balanced diet. New research from Boston Children’s is helping endocrinologists address these challenges and improve care 👇

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How do pain responses go from being protective — to avoid harm — to pain hypersensitivity, in which people experience debilitating pain from harmless stimuli such as a gentle touch? Clifford Woolf and colleagues in the F.M. Kirby Neurobiology Center at Boston Children's Hospital used calcium imaging to track signaling by key spinal projection neurons ...

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Congratulations to and Dr. Lois Smith and Research Fellow Deokho Lee for publishing important work regarding amino acids role in maintaining eye health in Life. 🌱

Amino acids, essential for protein and enzyme function, play a crucial role in cellular metabolism and eye health. Taurine and histidine are in amino acid-rich fo...

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