David Borsook, MD
Dr. Borsook’s program has been involved in understanding neural plasticity in pain pathways involving the trigeminal system, including trigeminal neuropathic pain and migraine. Their long-standing track record in imaging trigeminal system has more recently been applied to understanding changes in the migraine brain. In a collaboration that initially began with Rami Burstein PhD on a Program Project Grant (Michael Moskowitz MD PI), they have proceeded to evaluate changes in functional, structural and connectivity changes in the migraine brain. Their work has attracted attention from outside groups such as Oxford University Press and Dr. Borsook has been asked to lead an effort to publish a book on imaging the migraine brain due out in 2011. Migraine provides a unique model to understand changes in brain function.
Dr. Borsook’s program now has ongoing projects at Children’s Hospital on evaluating functional and structural changes in brain function and completing an R01 on migraine and central sensitization. They are one of the leading groups on evaluating drug effects on brain function using fMRI, and have projects involved in evaluating drug action on the migraine brain. Taken together these are all cutting edge neuroimaging applications in an attempt to dissect and understand some of the major problems in migraine including the transformation from acute to the chronic migraine state.