Anesthesiology Research

Dr. Soriano’s basic science work encompasses two themes: 1. adhesion molecules and cerebral ischemia and 2. neurotoxicity of anesthetic drugs on the developing brain.  He has published several studies demonstrating the essential role of adhesion in cerebral ischemia. Ongoing studies now look at the effects of anesthetics on adhesion molecule function; with the intention of using them as anti-inflammatory agents in the setting of anesthesia and critical care. Anesthetic-induced developmental neurotoxicity is an area of investigation that has significant impact on the practice of pediatric anesthesia.

With the perspective of a pediatric anesthesiologist, Dr. Soriano is utilizing clinically relevant paradigms in preclinical (rodent and cell culture) models. These paradigms include the effect of concurrent noxious stimulation and adjuvant drugs (dexmedetomidine and lithium) on anesthetic-induced neuroapoptosis.