Anesthesiology Research

Dr. Yuki is currently an anesthesia staff at the Department of Anesthesiology, Perioperative and Pain Medicine, Children’s Hospital Boston and an assistant professor of Anaesthesia, Harvard Medical School.

Dr. Yuki has been interested in the mechanism of immunomodulation by volatile anesthetics and he joined Dr. Motomu Shimaoka’s laboratory at the Center for Blood Research (a.k.a., Immune Disease Institute) as a postdoctoral fellow in 2006. Dr. Yuki found that isoflurane and sevoflurane interact with integrin, lymphocyte function-associated antigen-1 (LFA-1) and inhibit its function and has learned various integrin-related functional assays using ELISA, flow cytometry and flat bottom or V-bottom binding assays. Dr. Yuki has continued to work on this topic and his work was published as three, first author peer-reviewed articles.

Currently, Dr. Yuki is interested in how commonly used anesthetics interact with leukocyte related integrins structurally and what the immunological disturbances will be as results of anesthetics-integrin interactions.