Immunology
The Division of Immunology has a long track record of cutting edge research in allergic and immunological mechanisms and is recognized world-wide for work on IgE regulation, Current areas of basic research include:
- Pathogenesis of atopic dermatitis
- Wiskott Aldrich Syndrome protein (WASP) and associated molecules
- Signal transduction by the T cell receptor, the role of SLP-76
- Regulation of IgE production
- Roles of IgE in allergic pathogenesis and parasite immunity
- TRAF functions in TNF receptor family signaling
Ongoing clinical projects include:
- The evaluation of immunomodulators in asthma and atopic dermatitis.
- A study of the efficacy of purified C1 esterase inhibitor in hereditary angioneurotic edema.
- The evaluation of intravenous gammaglobulin treatment of patients with antibody deficiency disorders.
- Studies of the use of anti_IgE in the treatment of asthma and atopic dermatitis.
Featured researchers in the Division of Immunology hold faculty appointments at Harvard Medical School.
Latest Research in Immunology:
| Researcher | Focus Area |
|---|---|
| Raif Geha, MD | Immune deficiencies |
| Luigi Daniele Notarangelo, MD | Cellular bases of congenital immunodeficiencies |
| Hans Oettgen, MD, PhD | Allergy |
| Narayanaswamy Ramesh, PhD | Molecular basis of primary immunodeficiencies |
| Lynda Schneider, MD | Allergy |
| Dale T. Umetsu, MD, PhD | The immunobiology of asthma and allergy |
