Neurogenic Bladder | Symptoms & Causes
What are the symptoms of neurogenic bladder?
- Urinary incontinence: Your child may feel the need to urinate frequently and with urgency, as well as experience small urine volume during urination, dribbling urine and loss of sensation of bladder fullness.
- Urinary tract infection: An infection can result from urine being held in the bladder too long.
- Kidney injury: These occur as a result of high pressures caused by urine back-up in the bladder.
- Kidney stones: These may be difficult to diagnose because your child may not be able to feel pain associated with kidney stones if they have spinal cord abnormalities. Symptoms of kidney stones include:
- Pain
- Blood in urine
- Fever and chills: This indicates a urinary tract infection caused by an obstructing stone.
What causes neurogenic bladder?
In children, a neurogenic bladder may be caused by a birth defect, usually one involving the spinal cord, or it may be acquired as the result of a different problem. Here we look at some of the most common causes of neurogenic bladder:
- Spinal cord trauma
- Central nervous system tumors
- Pelvic tumors
- Spina bifida (myelodysplasia): A birth defect in which the spinal canal does not close completely, exposing the developing spinal cord to injury. Some types of spina bifida are obvious at birth, while others are subtle and only detected by careful inspection of the spine and legs. Spina bifida accounts for 90 percent of cases of neurogenic bladder.
Neurogenic Bladder | Diagnosis & Treatments
How is neurogenic bladder diagnosed?
The first step in treating your child is forming an accurate and complete diagnosis. The symptoms of neurogenic bladder often resemble those of other health conditions, so your child's physician will need to take a complete medical history and do a careful physical examination to rule out other medical issues. Specific diagnostic procedures for neurogenic bladder may include:
- A urodynamics study: Your child's bladder will be filled with warm saltwater to assess how the bladder and urethral sphincter function during the stages of bladder filling and emptying. At the same time, bladder volume and pressure are measured, as well as the tone or amount of contraction of the bladder. In some instances, urodynamics testing might include an EMG (an electromyogram using needle electrodes) of the sphincter, performed by a neurologist.
- Radiologic testing: This includes an ultrasound or a voiding cystourethrogram (VCUG), which is an X-ray exam of your child’s bladder and lower urinary tract that uses a special form of X-ray called fluoroscopy. This makes it possible to see internal organs in motion.
After we complete all necessary tests, our experts meet to review and discuss what they have learned about your child's condition. Then we will meet with you and your family to discuss the results and outline the best treatment options.
How is neurogenic bladder treated?
Your child's treatment for neurogenic bladder may include:
- Insertion of a very small catheter, or hollow tube, to empty the bladder at regular intervals
- Antibiotics to prevent urinary tract infection
- Medication to help relax the bladder
- Surgery to enlarge the bladder if it is very small and not responsive to medication
- Surgery to insert an artificial sphincter or a bladder neck sling, both of which can be used to prevent urinary incontinence
In caring for patients affected by neurogenic bladder, what sets Boston Children's apart are innovations in two key areas:
- Tissue engineering: Typically, surgeons use a patient's intestinal tissue to enlarge the bladder. However, the incompatibility of intestinal tissue and bladder tissue can lead to complications. At Boston Children's, we've pioneered innovations in engineering tissue (growing tissue in the laboratory using the patients' own cells).
- Using special techniques, our doctors can grow enough of the patient's own bladder tissue to enlarge or replace the bladder.
- The world's first recipients of tissue augments to enlarge the bladder were at Boston Children's.
- In conjunction with the Harvard Stem Cell Institute, we are testing the use of embryonic stem cells and induced pluripotent stem (iPS) cells to augment bladder tissue, as well as the use of novel materials, like silk.
- Urodynamics testing: Our long-standing Neurourology Unit comprehensively evaluates children's lower urinary tract. We offer urodynamics testing in both Boston and Waltham to closely evaluate how the bladder carries out its two main functions: filling and emptying. The results of this testing allows your child's physicians to better diagnose and treat a neurogenic bladder.
How we care for neurogenic bladder
As the largest pediatric urology service in the world, Children’s Department of Urology performs more than 3,000 surgical procedures each year and cares for almost 18,000 children. Our team of pediatric urologists have extensive experience treating children with neurogenic bladder dysfunction.
The reality is that neurogenic bladder dysfunction is almost always part of a larger problem; it rarely, if ever, occurs on its own. It’s a common complication of spina bifida (myelodysplasia), a condition in which there’s abnormal development of the spinal cord, and can also be a complication of spinal cord trauma, tumors in the central nervous system and pelvic tumors. Children's has one of the country’s oldest and largest comprehensive interdisciplinary centers for the care of children with spina bifida.
Our doctors take a multidisciplinary approach to diagnosing and treating your child’s neurogenic bladder, enlisting care from doctors and nurses from Boston Children's Departments of Neurology, Urology, Complex Care Pediatrics, Neurosurgery, Nephrology, Gastroenterology, and Pediatric Surgery.
Neurogenic Bladder | Research & Innovation
Our areas of innovation for neurogenic bladder
Boston Children's Hospital is continually working toward faster, more accurate diagnoses and more effective treatments for children with urologic disorders. Recent areas of research that our Department of Urology has conducted that hold promise for improving the lives of children with neurogenic bladder include:
- Tissue engineering: Typically, surgeons use a patient’s intestinal tissue to enlarge the bladder. However, the incompatibility of intestinal tissue and bladder tissue can lead to complications. At Children’s, we’ve pioneered innovations in engineering tissue (growing tissue in the laboratory using the patients’ own cells).
- Using special techniques, our doctors can grow enough of the patient’s own bladder tissue to enlarge or replace the bladder.
- The world’s first recipients of tissue augments to enlarge the bladder were at Children’s.
- Stem cell research: In conjunction with the Harvard Stem Cell Institute, we are testing the use of embryonic stem cells and induced pluripotent stem (iPS) cells to augment bladder tissue, as well as the use of novel materials, like silk.
Read more about our Department of Urology.
