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Related Research Units

Computational Health Informatics Program Research

Research Overview

Dr. Alal Eran is a computational biologist studying the molecular basis of autism.  She is fascinated by the clinical and molecular complexity of neurodevelopmental disorders, and enthusiastic about the possibilities of deciphering their underlying gene-environment interactions by integrating large datasets of functional genomic measurements and clinical information.

Dr. Eran has been studying RNA-mediated regulation at the synapse of children with autism as compared to neurotypical individuals, using deep sequencing of RNA and DNA.  She is interested in understanding the diagnostic and prognostic values of A-to-I RNA editing levels, striving to enable earlier diagnosis and more personalized care for children with autism.

Publications

  1. The IL-10 receptor inhibits cell extrinsic signals necessary for STAT1-dependent macrophage accumulation during colitis. Mucosal Immunol. 2023 06; 16(3):233-249. View Abstract
  2. Web and social media searches highlight menstrual irregularities as a global concern in COVID-19 vaccinations. Sci Rep. 2022 10 21; 12(1):17657. View Abstract
  3. Clinical Phenotypes and Outcomes in Monogenic Versus Non-monogenic Very Early Onset Inflammatory Bowel Disease. J Crohns Colitis. 2022 Sep 08; 16(9):1380-1396. View Abstract
  4. Reexamining empathy in autism: Empathic disequilibrium as a novel predictor of autism diagnosis and autistic traits. Autism Res. 2022 10; 15(10):1917-1928. View Abstract
  5. Human mitochondrial RNA modifications associate with tissue-specific changes in gene expression, and are affected by sunlight and UV exposure. Eur J Hum Genet. 2022 12; 30(12):1363-1372. View Abstract
  6. Multimodal bioinformatic analyses of the neurodegenerative disease-associated TECPR2 gene reveal its diverse roles. J Med Genet. 2022 Oct; 59(10):1002-1009. View Abstract
  7. The Effect of Antibiotic Treatment of Early Childhood Shigellosis on Long-Term Prevalence of Attention Deficit/Hyperactivity Disorder. Children (Basel). 2021 Oct 02; 8(10). View Abstract
  8. Melanocytes determine angiogenesis gene expression across human tissues. PLoS One. 2021; 16(5):e0251121. View Abstract
  9. The National Autism Database of Israel: a Resource for Studying Autism Risk Factors, Biomarkers, Outcome Measures, and Treatment Efficacy. J Mol Neurosci. 2020 09; 70(9):1303-1312. View Abstract
  10. A multidimensional precision medicine approach identifies an autism subtype characterized by dyslipidemia. Nat Med. 2020 09; 26(9):1375-1379. View Abstract
  11. Racial disparity in Covid-19 mortality rates - A plausible explanation. Clin Immunol. 2020 08; 217:108481. View Abstract
  12. Efficient Genomic Interval Queries Using Augmented Range Trees. Sci Rep. 2019 03 25; 9(1):5059. View Abstract
  13. Association of Sex With Recurrence of Autism Spectrum Disorder Among Siblings. JAMA Pediatr. 2017 11 01; 171(11):1107-1112. View Abstract
  14. Combining clinical and genomics queries using i2b2 - Three methods. PLoS One. 2017; 12(4):e0172187. View Abstract
  15. A model-driven methodology for exploring complex disease comorbidities applied to autism spectrum disorder and inflammatory bowel disease. J Biomed Inform. 2016 10; 63:366-378. View Abstract
  16. Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype. Cell. 2015 Nov 19; 163(5):1204-1213. View Abstract
  17. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2015 Aug 01; 24(15):4480-1. View Abstract
  18. Dystrophic muscle improvement in zebrafish via increased heme oxygenase signaling. Hum Mol Genet. 2014 Apr 01; 23(7):1869-78. View Abstract
  19. Can we measure autism? Sci Transl Med. 2013 Oct 30; 5(209):209ed18. View Abstract
  20. Haplotype structure enables prioritization of common markers and candidate genes in autism spectrum disorder. Transl Psychiatry. 2013 May 28; 3:e262. View Abstract
  21. Characteristics and predictive value of blood transcriptome signature in males with autism spectrum disorders. PLoS One. 2012; 7(12):e49475. View Abstract
  22. Comparative RNA editing in autistic and neurotypical cerebella. Mol Psychiatry. 2013 Sep; 18(9):1041-8. View Abstract
  23. Characterization of recovery and neuropsychological consequences of orbitofrontal lesion: A case study. Neurocase. 2011 Jun; 17(3):285-93. View Abstract
  24. Comment on "Autistic-like phenotypes in Cadps2-knockout mice and aberrant CADPS2 splicing in autistic patients". J Clin Invest. 2009 Apr; 119(4):679-80; author reply 680-1. View Abstract
  25. Distinctive patterns of microRNA expression in primary muscular disorders. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):17016-21. View Abstract

Contact Alal Eran

Phone: 617-412-1561
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