Information

Related Research Units

Gastroenterology, Hepatology and Nutrition Research
Lencer Laboratory Research

Research Overview

Katlynn Bugda Gwilt is an epithelial biologist working on polarity in the intestinal epithelium, and how the epithelium interacts with its environment. Dr. Bugda Gwilt trained with Dr. Gregory Miller investigating how dietary amines, via TAAR1, could augment intestinal enteropathies. Currently, at Boston Children’s Hospital, she works as a research fellow with Dr. Wayne Lencer and Dr. Jay Thiagarajah to study the mechanisms underlying congenital diarrheal enteropathies using patient derived intestinal organoids. Her work focuses on establishing methods for high-content, high-resolution microscopy to investigate the underlying cellular architecture typifying disease, as well as translating existing functional assays into patient derived organoid models to discover novel therapeutics for disease.

Research Background

Katlynn completed her B.Sc. in Biology (Cellular and Molecular Biology) from Syracuse University and her Ph.D in Pharmacology from Northeastern University. Dr. Bugda Gwilt enjoys mentoring, teaching and community outreach in addition to her scientific pursuits.

Publications

  1. Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair. Cell. 2024 Dec 26; 187(26):7533-7550.e23. View Abstract
  2. Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease. PLoS One. 2024; 19(11):e0309072. View Abstract
  3. Protocol for measuring transcytosis and recycling of IgG in intestinal epithelial Caco-2 cells and primary human intestinal organoids. STAR Protoc. 2023 05 25; 4(2):102335. View Abstract
  4. The epithelial-specific ER stress sensor ERN2/IRE1ß enables host-microbiota crosstalk to affect colon goblet cell development. J Clin Invest. 2022 09 01; 132(17). View Abstract
  5. Membrane Lipids in Epithelial Polarity: Sorting out the PIPs. Front Cell Dev Biol. 2022; 10:893960. View Abstract
  6. Depletion of the apical endosome in response to viruses and bacterial toxins provides cell-autonomous host defense at mucosal surfaces. Cell Host Microbe. 2022 02 09; 30(2):216-231.e5. View Abstract
  7. Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Skelet Muscle. 2020 11 27; 10(1):34. View Abstract
  8. Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27502-27508. View Abstract
  9. Actions of Trace Amines in the Brain-Gut-Microbiome Axis via Trace Amine-Associated Receptor-1 (TAAR1). Cell Mol Neurobiol. 2020 Mar; 40(2):191-201. View Abstract
  10. Trace amine associated receptor 1 (TAAR1) expression and modulation of inflammatory cytokine production in mouse bone marrow-derived macrophages: a novel mechanism for inflammation in ulcerative colitis. Immunopharmacol Immunotoxicol. 2019 12; 41(6):577-585. View Abstract
  11. Transgenic zebrafish model of DUX4 misexpression reveals a developmental role in FSHD pathogenesis. Hum Mol Genet. 2019 01 15; 28(2):320-331. View Abstract

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