Research Overview

My research is focused on the nutritional and metabolic aspects of critical illness in children, aimed at identifying and implementing optimal nutrition therapies that improve clinical outcomes. With intramural and extramural support, I have systematically conducted investigations to address knowledge and evidence gaps in the field. Some of our original observations and contributions to the literature include the following i) prevalence of both underfeeding and overfeeding (calories) in the intensive care unit, ii) role of targeted indirect calorimetry to guide optimal energy intake, iii) inadequacy of protein intake in critically ill infants and children worldwide; iv) unintended cumulative deficits of protein and muscle loss; v) protein requirement during critical illness; vi) tools to examine of protein flux, metabolism, balance and the lean body mass; vii) bedside body composition measurement; viii) barriers to and strategies for optimal enteral nutrition, ix) delayed gastric emptying during critical illness, and x) best-practice algorithms for optimal bedside nutrient delivery.

My group has extensive experience with stable isotope methodology for protein turnover, body composition, total body water and energy expenditure determination in humans and animal models. We perform studies that use a variety of body composition analysis techniques, including BIA, BIS, muscle ultrasound, and DXA.

We have demonstrated the impact of individualized diet (optimized energy and protein intake based on measured energy expenditure and protein requirements) in chronically ventilated children. We are currently conducting a randomized controlled double-blind trial of antacids versus placebo, in infants with congenital heart disease, exploring the safety profile and impact on gastrointestinal microbiome of withholding antacids in this group. I have completed 3 large international studies of nutrient intake in over 3000 mechanically ventilated children from 90 PICUs (from over 15 countries) and demonstrated significant associations between nutrient delivery and outcomes such as mortality and acquired infections. These studies have helped establish a platform for future multicenter intervention trials.

Research Background

Dr. Mehta completed his residency at the Boston Combined Pediatric Residency Program, and Fellowship in Pediatric Critical Care Medicine at Boston Children’s Hospital. He is a Faculty member in the Critical Care Medicine, and Senior Associate in the Department of Anesthesia, Critical Care and Pain Medicine. His prior training includes pediatric and critical training in the United Kingdom. As the founder and Director of the Critical Care Nutrition Program, he leads a group of multidisciplinary researchers in conducting clinical and translational studies in this field. He has received awards for outstanding research contributions from leading organizations including the World Federation of Pediatric and Intensive Care Societies (WFPICCS), the Society of Critical Care Medicine (SCCM) and the American Society of Critical Care Anesthesiologists (ASCCA). In 2014, he received the " Stanley Dudrick Research Scholar Award" from the American Society of Parenteral and Enteral Nutrition (ASPEN). He currently serves as the President of ASPEN.

Awards:

  1. Young Investigator Award, presented by the American Society of Critical Care Anesthesiologists for Outstanding Investigative Research. "Pharmacokinetic considerations during extracorporeal membrane oxygenation". ASCCA 2006 annual meeting, Chicago, IL.

Education

Medical School

T. N. Medical College
Bombay India

Internship

King Edward VII Memorial Hospital
Bombay India

Residency

Pediatric Medicine North Thames Deanery
London England

Residency

Pediatrics Boston Combined Residency Program (BCRP)
Boston MA

Fellowship

Critical Care Medicine Boston Children's Hospital
Boston MA

Fellowship

Pediatric Critical Care St. Mary's Hospital
Boston MA

Publications

  1. Using Implementation Science to Assess Barriers to Agreement on Sedation Goal Setting and Assessment. Pediatr Crit Care Med. 2025 Jan 01; 26(1):e51-e61. View Abstract
  2. Nutrition support in children with medical complexity and chronic critical illness: A narrative review. Nutr Clin Pract. 2025 Feb; 40(1):54-63. View Abstract
  3. Epidemiology and Regional Variation in Additional Surgical Interventions for Children with Congenital Diaphragmatic Hernia: A Multi-institutional Analysis. Ann Surg. 2024 Sep 17. View Abstract
  4. Nutrition Provision in Children with Heart Disease on Extracorporeal Membrane Oxygenation (ECMO). Pediatr Cardiol. 2024 Aug 26. View Abstract
  5. The enteroendocrine axis and its effect on gastrointestinal function, nutrition, and inflammation. Curr Opin Crit Care. 2024 Aug 01; 30(4):290-297. View Abstract
  6. Changes in Global Nutrition Practices in Critically Ill Children and the Influence of Emerging Evidence: A Secondary Analysis of the Pediatric International Nutrition Studies, 2009-2018. J Acad Nutr Diet. 2024 Dec; 124(12):1657-1667.e5. View Abstract
  7. Comparing the Quality of Domain-Specific Versus General Language Models for Artificial Intelligence-Generated Differential Diagnoses in PICU Patients. Pediatr Crit Care Med. 2024 Jun 01; 25(6):e273-e282. View Abstract
  8. Automated Calculator for the Pediatric Sequential Organ Failure Assessment Score: Development and External Validation in a Single-Center 7-Year Cohort, 2015-2021. Pediatr Crit Care Med. 2024 May 01; 25(5):434-442. View Abstract
  9. Dynamic Prediction of Mortality Using Longitudinally Measured Pediatric Sequential Organ Failure Assessment Scores: A Joint Modeling Approach. Pediatr Crit Care Med. 2024 May 01; 25(5):443-451. View Abstract
  10. Stress Ulcer Prophylaxis Versus Placebo-A Blinded Pilot Randomized Controlled Trial to Evaluate the Safety of Two Strategies in Critically Ill Infants With Congenital Heart Disease. Pediatr Crit Care Med. 2024 Feb 01; 25(2):118-127. View Abstract
  11. Medication Errors: Detection Methodology Matters. J Patient Saf. 2024 03 01; 20(2):e6-e7. View Abstract
  12. Improving anthropometric measurements in hospitalized children: A quality-improvement project. Nutr Clin Pract. 2024 Jun; 39(3):685-695. View Abstract
  13. Determining energy and protein needs in critically ill pediatric patients: A scoping review. Nutr Clin Pract. 2023 Oct; 38 Suppl 2:S103-S124. View Abstract
  14. Heart Rate Change as a Potential Digital Biomarker of Brain Death in Critically Ill Children With Acute Catastrophic Brain Injury. Crit Care Explor. 2023 May; 5(5):e0908. View Abstract
  15. Long-Term Functional Outcomes at 1-Year After Hospital Discharge in Critically Ill Neonates With Congenital Diaphragmatic Hernia. Pediatr Crit Care Med. 2023 08 01; 24(8):e372-e381. View Abstract
  16. Validation and Extension of the Association Between Potentially Excess Oxygen Exposure and Death in Mechanically Ventilated Children. Pediatr Crit Care Med. 2023 09 01; 24(9):e434-e440. View Abstract
  17. Postpyloric vs gastric enteral nutrition in critically ill children: A single-center retrospective cohort study. JPEN J Parenter Enteral Nutr. 2023 05; 47(4):494-500. View Abstract
  18. Impact of implementing an evidence-based definition of enteral nutrition intolerance on nutrition delivery: A prospective, cross-sectional cohort study. Nutr Clin Pract. 2023 Apr; 38(2):376-385. View Abstract
  19. Intermittent versus continuous enteral nutrition in critically ill children: A pre-planned secondary analysis of an international prospective cohort study. Clin Nutr. 2022 12; 41(12):2621-2627. View Abstract
  20. Quality measurement and surveillance platforms in critically ill children: A scoping review. Aust Crit Care. 2023 Jul; 36(4):499-508. View Abstract
  21. Bio-impedance spectroscopy for total body water assessment in pediatric surgical patients: A single center pilot cohort study. J Pediatr Surg. 2022 Dec; 57(12):962-966. View Abstract
  22. Implementation Science in Pediatric Critical Care - Sedation and Analgesia Practices as a Case Study. Front Pediatr. 2022; 10:864029. View Abstract
  23. The Zonulin Pathway as a Potential Mediator of Gastrointestinal Dysfunction in Critical Illness. Pediatr Crit Care Med. 2022 09 01; 23(9):e424-e428. View Abstract
  24. Nutritional screening tool for critically ill children: a systematic review. Nutr Rev. 2022 05 09; 80(6):1392-1418. View Abstract
  25. Resuscitation With Vitamins C and B1 in Pediatric Sepsis-Hold on to Your "HAT". Pediatr Crit Care Med. 2022 05 01; 23(5):385-389. View Abstract
  26. Supraventricular Tachycardia in Infants With Congenital Diaphragmatic Hernia: Prevalence, Associations, and Outcomes. Pediatr Crit Care Med. 2022 07 01; 23(7):e329-e337. View Abstract
  27. Feasibility of bioimpedance spectroscopy and long-term functional assessment in critically ill children. Clin Nutr ESPEN. 2022 02; 47:405-409. View Abstract
  28. Association Between Anticholinergic Drug Burden and Adequacy of Enteral Nutrition in Critically Ill, Mechanically Ventilated Pediatric Patients. Pediatr Crit Care Med. 2021 12 01; 22(12):1083-1087. View Abstract
  29. Novel role of zonulin in the pathophysiology of gastro-duodenal transit: a clinical and translational study. Sci Rep. 2021 11 17; 11(1):22462. View Abstract
  30. Time to achieve delivery of nutrition targets is associated with clinical outcomes in critically ill children. Am J Clin Nutr. 2021 11 08; 114(5):1859-1867. View Abstract
  31. Artificial Neural Network Algorithms to Predict Resting Energy Expenditure in Critically Ill Children. Nutrients. 2021 Oct 26; 13(11). View Abstract
  32. Fluid Restriction Contributes to Poor Nutritional Adequacy in Patients With Congenital Heart Disease Receiving Renal Replacement Therapy. J Ren Nutr. 2022 01; 32(1):78-86. View Abstract
  33. Ultrasound Assessment of Quadriceps Femoris Muscle Thickness in Critically Ill Children. Pediatr Crit Care Med. 2021 10 01; 22(10):889-897. View Abstract
  34. Implementation of an Analgesia-Sedation Protocol Is Associated With Reduction in Midazolam Usage in the PICU. Pediatr Crit Care Med. 2021 10 01; 22(10):e513-e523. View Abstract
  35. eSIMPLER: A Dynamic, Electronic Health Record-Integrated Checklist for Clinical Decision Support During PICU Daily Rounds. Pediatr Crit Care Med. 2021 10 01; 22(10):898-905. View Abstract
  36. "Closing the chasm" - guidelines bridge the gap from evidence to implementation. Pediatr Investig. 2021 Sep; 5(3):163-166. View Abstract
  37. Nutrition therapy and outcomes in hospitalized children. JPEN J Parenter Enteral Nutr. 2021 09; 45(7):1392-1394. View Abstract
  38. Nutrition delivery and growth outcomes in infants with long-gap esophageal atresia who undergo the Foker process. J Pediatr Surg. 2021 Dec; 56(12):2133-2139. View Abstract
  39. A Machine Learning Classifier Improves Mortality Prediction Compared With Pediatric Logistic Organ Dysfunction-2 Score: Model Development and Validation. Crit Care Explor. 2021 May; 3(5):e0426. View Abstract
  40. Admission factors associated with nutritional status deterioration and prolonged pediatric intensive care unit stay in critically ill children: PICU-ScREEN multicenter study. JPEN J Parenter Enteral Nutr. 2022 02; 46(2):330-338. View Abstract
  41. Metabolism and energy prescription in critically ill children. Minerva Anestesiol. 2021 09; 87(9):1025-1033. View Abstract
  42. Timing of parenteral nutrition is associated with adequacy of nutrient delivery and anthropometry in critically ill children: A single-center study. JPEN J Parenter Enteral Nutr. 2022 01; 46(1):190-196. View Abstract
  43. Stewardship Intervention to Optimize Central Venous Catheter Utilization in Critically Ill Children. Pediatr Qual Saf. 2021 Mar-Apr; 6(2):e389. View Abstract
  44. Pediatric Sarcopenia: Hidden in Plain Sight? J Pediatr Gastroenterol Nutr. 2021 02 01; 72(2):181-183. View Abstract
  45. Sample Preparation for High-Throughput Urine Proteomics Using 96-Well Polyvinylidene Fluoride (PVDF) Membranes. Adv Exp Med Biol. 2021; 1306:1-12. View Abstract
  46. Current State of Nutrition Education in Pediatric Critical Care Medicine Fellowship Programs in the United States and Canada. Pediatr Crit Care Med. 2020 09; 21(9):e769-e775. View Abstract
  47. Biomarkers in critical care nutrition. Crit Care. 2020 08 12; 24(1):499. View Abstract
  48. Estimating Energy Expenditure and Metabolism at the Bedside-Still Shooting in the Dark? Pediatr Crit Care Med. 2020 08; 21(8):776-777. View Abstract
  49. Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD). Trials. 2020 Jun 29; 21(1):590. View Abstract
  50. Interleukin-10 and Zonulin Are Associated With Postoperative Delayed Gastric Emptying in Critically Ill Surgical Pediatric Patients: A Prospective Pilot Study. JPEN J Parenter Enteral Nutr. 2020 11; 44(8):1407-1416. View Abstract
  51. Forty-Third ASPEN Presidential Address: "Our Time Is Now-Challenges and Strategies for the Field of Nutrition". JPEN J Parenter Enteral Nutr. 2020 05; 44(4):567-580. View Abstract
  52. Early Enteral Nutrition Is Associated With Improved Clinical Outcomes in Critically Ill Children: A Secondary Analysis of Nutrition Support in the Heart and Lung Failure-Pediatric Insulin Titration Trial. Pediatr Crit Care Med. 2020 03; 21(3):213-221. View Abstract
  53. Long-term outcomes related to timing of parenteral nutrition in critically ill children. Lancet Respir Med. 2020 03; 8(3):224-226. View Abstract
  54. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):e52-e106. View Abstract
  55. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatr Crit Care Med. 2020 02; 21(2):186-195. View Abstract
  56. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):10-67. View Abstract
  57. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Med. 2020 02; 46(Suppl 1):1-9. View Abstract
  58. Bedside Postpyloric Tube Placement and Enteral Nutrition Delivery in the Pediatric Intensive Care Unit. Nutr Clin Pract. 2020 Apr; 35(2):299-305. View Abstract
  59. Multidisciplinary Quality Improvement Intervention to Achieve Sustained Improvement in Hand Hygiene Reliability in a Pediatric Intensive Care Unit. Pediatr Qual Saf. 2019 Nov-Dec; 4(6):e227. View Abstract
  60. Undernutrition at PICU Admission Is Predictor of 60-Day Mortality and PICU Length of Stay in Critically Ill Children. J Acad Nutr Diet. 2020 02; 120(2):219-229. View Abstract
  61. ICU Management & Practice. Ed. J.L.Vincent. Emerging Concepts in Nutritional Therapy for the Critically Ill Child. 2019; 19(3):150-157. View Abstract
  62. From body habitus to body composition-Predicting outcomes in the PICU. J Pediatr. 2019 10; 213:248. View Abstract
  63. Gastrointestinal Hormone Profiles Associated With Enteral Nutrition Tolerance and Gastric Emptying in Pediatric Critical Illness: A Pilot Study. JPEN J Parenter Enteral Nutr. 2020 03; 44(3):472-480. View Abstract
  64. ICU Management & Practice, Ed. J.L. Vincent. Quality improvement in the PICU – a primer for intensivists. 2019; 19(2):74-77. View Abstract
  65. Incorporating the latest pediatric nutrition support guidelines into clinical practice. Nursing. 2019 Feb; 49(2):38-44. View Abstract
  66. Priorities for Nutrition Research in Pediatric Critical Care. JPEN J Parenter Enteral Nutr. 2019 09; 43(7):853-862. View Abstract
  67. Nutritional Status and Outcomes in Pediatric Severe Sepsis-Size Matters. Crit Care Med. 2018 11; 46(11):1886-1887. View Abstract
  68. Nutrition Support During Pediatric Extracorporeal Membrane Oxygenation. Nutr Clin Pract. 2018 Dec; 33(6):747-753. View Abstract
  69. Micronutrients in Critical Illness: Essential and Enigmatic. Pediatr Crit Care Med. 2018 09; 19(9):907-908. View Abstract
  70. Research Agenda 2018: The American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2018 Jul; 42(5):838-844. View Abstract
  71. Enteral Protein Supplementation in Critically Ill Children: A Randomized Controlled Pilot and Feasibility Study. JPEN J Parenter Enteral Nutr. 2019 02; 43(2):281-289. View Abstract
  72. Nutrition for term neonates in the paediatric intensive care unit. Lancet Child Adolesc Health. 2018 07; 2(7):469-471. View Abstract
  73. Nutrition Delivery During Pediatric Extracorporeal Membrane Oxygenation Therapy. JPEN J Parenter Enteral Nutr. 2018 Sep; 42(7):1133-1138. View Abstract
  74. Comprehensive nutritional and metabolic assessment in patients with spinal muscular atrophy: Opportunity for an individualized approach. Neuromuscul Disord. 2018 06; 28(6):512-519. View Abstract
  75. Unexplained iron deficiency anemia: does Helicobacter pylori have a role to play? Gastroenterol Rep (Oxf). 2018 Aug; 6(3):215-220. View Abstract
  76. Feeding the Critically Ill Child. 2018. View Abstract
  77. Nutrition Delivery and Growth Outcomes in Infants With Gastroschisis. JPEN J Parenter Enteral Nutr. 2018 Jul; 42(5):913-919. View Abstract
  78. Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single-Dose 15 N Glycine Stable Isotope Protocol With End-Product Enrichment. JPEN J Parenter Enteral Nutr. 2018 02; 42(2):361-370. View Abstract
  79. Feasibility of Enteral Protein Supplementation in Critically Ill Children. JPEN J Parenter Enteral Nutr. 2018 01; 42(1):61-70. View Abstract
  80. The Quest to Preserve Muscle Mass-Lessons From Pediatric Burn Injury. Pediatr Crit Care Med. 2017 12; 18(12):1186-1187. View Abstract
  81. Response to "Pediatric Intensive Care Nutrition Guidelines 2017: Key Questions Remain Unanswered". JPEN J Parenter Enteral Nutr. 2018 01; 42(1):10-11. View Abstract
  82. Body Composition in Children with Chronic Illness: Accuracy of Bedside Assessment Techniques. J Pediatr. 2017 11; 190:56-62. View Abstract
  83. Strain-dependence of the Angelman Syndrome phenotypes in Ube3a maternal deficiency mice. Sci Rep. 2017 08 16; 7(1):8451. View Abstract
  84. Ultrasound Measurement of Muscle Thickness: A Novel Biomarker for the PICU? Pediatr Crit Care Med. 2017 08; 18(8):817-819. View Abstract
  85. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. Pediatr Crit Care Med. 2017 Jul; 18(7):675-715. View Abstract
  86. Risk Factors for Fractures in Children Hospitalized in Intensive and Intermediate Care Units. Hosp Pediatr. 2017 Jul; 7(7):395-402. View Abstract
  87. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition. JPEN J Parenter Enteral Nutr. 2017 07; 41(5):706-742. View Abstract
  88. Impact of the structure and dose of protein intake on clinical and metabolic outcomes in critically ill children: A systematic review. Nutrition. 2017 Sep; 41:97-106. View Abstract
  89. Timing of the initiation of parenteral nutrition in critically ill children. Curr Opin Clin Nutr Metab Care. 2017 May; 20(3):227-231. View Abstract
  90. Nutritional Assessment Must be Prioritized for Critically Ill Children in the PICU. Crit Care Med. 2017 04; 45(4):e464. View Abstract
  91. Estimating Energy Expenditure in Critically Ill Children: Still Shooting in the Dark? J Pediatr. 2017 05; 184:10-12. View Abstract
  92. Accuracy of Oxygen Consumption and Carbon Dioxide Elimination Measurements in 2 Breath-by-Breath Devices. Respir Care. 2017 Apr; 62(4):475-480. View Abstract
  93. Gastric Emptying in Critically Ill Children. JPEN J Parenter Enteral Nutr. 2017 09; 41(7):1100-1109. View Abstract
  94. Optimal nutrition therapy in paediatric critical care in the Asia-Pacific and Middle East: a consensus. Asia Pac J Clin Nutr. 2016 Dec; 25(4):676-696. View Abstract
  95. 450: SUBOPTIMAL PROTEIN INTAKE MAY PROLONG CICU LENGTH OF STAY AND WORSEN NUTRITIONAL STATUS IN CHILDREN. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View Abstract
  96. 451: INACCURACY OF EXISTING FAT-FREE MASS EQUATIONS IN PEDIATRICS-AND A NEW MACHINE LEARNING METHOD. Crit Care Med. 2016 Dec; 44(12 Suppl 1):189. View Abstract
  97. 462: BEDSIDE VCO2 AS A GUIDE TO INDIVIDUALIZED ENERGY PRESCRIPTION IN VENTILATED CHILDREN IN THE CICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):192. View Abstract
  98. 478: PROTEIN DELIVERY DURING THE FIRST WEEK OF PEDIATRIC ECMO: IMPACT ON OUTCOMES. Crit Care Med. 2016 Dec; 44(12 Suppl 1):196. View Abstract
  99. 1074: SEVERITY OF HEMODYNAMIC INSTABILITY AROUND HIGH-DOSE VASOACTIVE SYRINGE CHANGES IN THE PICU. Crit Care Med. 2016 Dec; 44(12 Suppl 1):344. View Abstract
  100. Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single-Dose 15N Glycine Stable Isotope Protocol With End-Product Enrichment. JPEN J Parenter Enteral Nutr. 2016 Nov 15. View Abstract
  101. Nutrient delivery in mechanically ventilated surgical patients in the pediatric critical care unit. J Pediatr Surg. 2017 Jan; 52(1):145-148. View Abstract
  102. Nutritional status, metabolic state and nutrient intake in children with bronchiolitis. Int J Food Sci Nutr. 2017 May; 68(3):378-383. View Abstract
  103. Energy and Protein Delivery in Overweight and Obese Children in the Pediatric Intensive Care Unit. Nutr Clin Pract. 2017 Jun; 32(3):414-419. View Abstract
  104. Enteral Nutrition and Acid-Suppressive Therapy in the PICU: Impact on the Risk of Ventilator-Associated Pneumonia. Pediatr Crit Care Med. 2016 10; 17(10):924-929. View Abstract
  105. The authors reply. Crit Care Med. 2016 10; 44(10):e1007-8. View Abstract
  106. Benefits of late parenteral nutrition in critically ill children. J Pediatr. 2016 09; 176:221-4. View Abstract
  107. The science and art of pediatric critical care nutrition. Curr Opin Crit Care. 2016 08; 22(4):316-24. View Abstract
  108. Nutritional Status Based on Body Mass Index Is Associated With Morbidity and Mortality in Mechanically Ventilated Critically Ill Children in the PICU. Crit Care Med. 2016 Aug; 44(8):1530-7. View Abstract
  109. Nutritional status as a predictor of duration of mechanical ventilation in critically ill children. Nutrition. 2017 Jan; 33:91-95. View Abstract
  110. Diagnosing Malnutrition: Where Are We and Where Do We Need to Go? J Acad Nutr Diet. 2016 05; 116(5):779-84. View Abstract
  111. Problems With Optimal Energy and Protein Delivery in the Pediatric Intensive Care Unit. Nutr Clin Pract. 2016 Oct; 31(5):673-80. View Abstract
  112. International Pediatric Otolaryngology Group (IPOG) consensus recommendations: Routine peri-operative pediatric tracheotomy care. Int J Pediatr Otorhinolaryngol. 2016 Jul; 86:250-5. View Abstract
  113. Parenteral Nutrition in Critically Ill Children. N Engl J Med. 2016 Mar 24; 374(12):1190-2. View Abstract
  114. Worldwide Survey of Nutritional Practices in PICUs. Pediatr Crit Care Med. 2016 Jan; 17(1):10-8. View Abstract
  115. Survey of contemporary feeding practices in critically ill children in the Asia-Pacific and the Middle East. Asia Pac J Clin Nutr. 2016; 25(1):118-25. View Abstract
  116. A Comparison of Carbon Dioxide Elimination Measurements Between a Portable Indirect Calorimeter and Volumetric Capnography Monitor: An In Vitro Simulation. Respir Care. 2016 Mar; 61(3):354-8. View Abstract
  117. Nutritional Status and Nutrient Intake Challenges in Children With Spinal Muscular Atrophy. Pediatr Neurol. 2016 Apr; 57:80-3. View Abstract
  118. Gastric Dysmotility in Critically Ill Children: Pathophysiology, Diagnosis, and Management. Pediatr Crit Care Med. 2015 Nov; 16(9):828-36. View Abstract
  119. Early Enteral Nutrition in the PICU: Should We Trust Our Gut? Pediatr Crit Care Med. 2015 Oct; 16(8):786-9. View Abstract
  120. Unplanned extubation: securing the tool of our trade. Intensive Care Med. 2015 Nov; 41(11):1983-5. View Abstract
  121. Impact of Individualized Diet Intervention on Body Composition and Respiratory Variables in Children With Respiratory Insufficiency: A Pilot Intervention Study. Pediatr Crit Care Med. 2015 Jul; 16(6):e157-64. View Abstract
  122. Adequate enteral protein intake is inversely associated with 60-d mortality in critically ill children: a multicenter, prospective, cohort study. Am J Clin Nutr. 2015 Jul; 102(1):199-206. View Abstract
  123. Validation of the V(max) metabolic cart in a simulated pediatric model. JPEN J Parenter Enteral Nutr. 2015 May; 39(4):387-8. View Abstract
  124. Bringing back the (weighing) balance in the PICU--for good measure. Pediatr Crit Care Med. 2015 Mar; 16(3):301-2. View Abstract
  125. Challenges to nutrition therapy in the pediatric critically ill obese patient. Nutr Clin Pract. 2015 Jun; 30(3):432-9. View Abstract
  126. Carbon dioxide elimination and oxygen consumption in mechanically ventilated children. Respir Care. 2015 May; 60(5):718-23. View Abstract
  127. Energy expenditure: how much does it matter in infant and pediatric chronic disorders? Pediatr Res. 2015 Jan; 77(1-2):168-72. View Abstract
  128. Metabolic assessment and individualized nutrition in children dependent on mechanical ventilation at home. J Pediatr. 2015 Feb; 166(2):350-7. View Abstract
  129. Nutritional outcomes in survivors of congenital diaphragmatic hernia (CDH)-factors associated with growth at one year. J Pediatr Surg. 2015 Jan; 50(1):74-7. View Abstract
  130. A stepwise enteral nutrition algorithm for critically ill children helps achieve nutrient delivery goals*. Pediatr Crit Care Med. 2014 Sep; 15(7):583-9. View Abstract
  131. Comparison of body composition assessment methods in pediatric intestinal failure. J Pediatr Gastroenterol Nutr. 2014 Jul; 59(1):99-105. View Abstract
  132. Variability of resting energy expenditure in infants and young children with intestinal failure-associated liver disease. J Pediatr Gastroenterol Nutr. 2014 May; 58(5):637-41. View Abstract
  133. Nutrition algorithms and bedside nutrient delivery practices in pediatric intensive care units: an international multicenter cohort study. Nutr Clin Pract. 2014 Jun; 29(3):360-7. View Abstract
  134. Current applications of metabolic monitoring in the pediatric intensive care unit. Nutr Clin Pract. 2014 Jun; 29(3):338-47. View Abstract
  135. Accuracy of a simplified equation for energy expenditure based on bedside volumetric carbon dioxide elimination measurement--a two-center study. Clin Nutr. 2015 Feb; 34(1):151-5. View Abstract
  136. Feeding the gut during critical illness--it is about time. JPEN J Parenter Enteral Nutr. 2014 May; 38(4):410-4. View Abstract
  137. Effective Nutritional Therapy. 8/2013. Online Video. 2013. View Abstract
  138. Influence of obesity on clinical outcomes in hospitalized children: a systematic review. JAMA Pediatr. 2013 May; 167(5):476-82. View Abstract
  139. The effect of preoperative nutritional status on postoperative outcomes in children undergoing surgery for congenital heart defects in San Francisco (UCSF) and Guatemala City (UNICAR). J Thorac Cardiovasc Surg. 2014 Jan; 147(1):442-50. View Abstract
  140. Accuracy of gas exchange monitoring during noninvasive ventilation: an in vitro metabolic simulation. JPEN J Parenter Enteral Nutr. 2014 Jan; 38(1):86-91. View Abstract
  141. Defining pediatric malnutrition: a paradigm shift toward etiology-related definitions. JPEN J Parenter Enteral Nutr. 2013 Jul; 37(4):460-81. View Abstract
  142. Gas exchange measurement during pediatric mechanical ventilation--agreement between gas sampling at the airway and the ventilator exhaust. Clin Nutr. 2013 Dec; 32(6):988-92. View Abstract
  143. The Goldilocks conundrum for optimal macronutrient delivery in the PICU--too much, too little, or just right? JPEN J Parenter Enteral Nutr. 2013 Mar; 37(2):178-80. View Abstract
  144. Nutritional practices and their relationship to clinical outcomes in critically ill children--an international multicenter cohort study*. Crit Care Med. 2012 Jul; 40(7):2204-11. View Abstract
  145. Resting energy expenditure after Fontan surgery in children with single-ventricle heart defects. JPEN J Parenter Enteral Nutr. 2012 Nov; 36(6):685-92. View Abstract
  146. Accuracy of abbreviated indirect calorimetry protocols for energy expenditure measurement in critically ill children. JPEN J Parenter Enteral Nutr. 2012 Nov; 36(6):693-9. View Abstract
  147. Nutrition therapy in the critically ill child. Curr Opin Crit Care. 2012 Apr; 18(2):192-8. View Abstract
  148. Systematic review of the influence of energy and protein intake on protein balance in critically ill children. J Pediatr. 2012 Aug; 161(2):333-9.e1. View Abstract
  149. Attenuation of resting energy expenditure following hematopoietic SCT in children. Bone Marrow Transplant. 2012 Oct; 47(10):1301-6. View Abstract
  150. Energy imbalance and the risk of overfeeding in critically ill children. Pediatr Crit Care Med. 2011 Jul; 12(4):398-405. View Abstract
  151. An open-label, single-arm, phase 2 trial of panitumumab plus FOLFIRI as second-line therapy in patients with metastatic colorectal cancer. Clin Colorectal Cancer. 2011 Sep; 10(3):171-7. View Abstract
  152. Factors associated with survival in pediatric extracorporeal membrane oxygenation--a single-center experience. J Pediatr Surg. 2010 Oct; 45(10):1995-2003. View Abstract
  153. Challenges to optimal enteral nutrition in a multidisciplinary pediatric intensive care unit. JPEN J Parenter Enteral Nutr. 2010 Jan-Feb; 34(1):38-45. View Abstract
  154. Nutritional deficiencies during critical illness. Pediatr Clin North Am. 2009 Oct; 56(5):1143-60. View Abstract
  155. Approach to enteral feeding in the PICU. Nutr Clin Pract. 2009 Jun-Jul; 24(3):377-87. View Abstract
  156. A.S.P.E.N. Clinical Guidelines: nutrition support of the critically ill child. JPEN J Parenter Enteral Nutr. 2009 May-Jun; 33(3):260-76. View Abstract
  157. Cumulative energy imbalance in the pediatric intensive care unit: role of targeted indirect calorimetry. JPEN J Parenter Enteral Nutr. 2009 May-Jun; 33(3):336-44. View Abstract
  158. Severe weight loss and hypermetabolic paroxysmal dysautonomia following hypoxic ischemic brain injury: the role of indirect calorimetry in the intensive care unit. JPEN J Parenter Enteral Nutr. 2008 May-Jun; 32(3):281-4. View Abstract
  159. Potential drug sequestration during extracorporeal membrane oxygenation: results from an ex vivo experiment. Intensive Care Med. 2007 Jun; 33(6):1018-24. View Abstract
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