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Related Research Units

Genetics and Genomics Research
Harris Laboratory Research

Research Overview

Comparative genomics with a focus on aging and age-related diseases, leveraging natural examples of exceptional longevity to decipher mechanisms facilitating senescence resistance. Animals that resist the rigors of time well past a human lifespan, that maintain health and function for centuries, will inform therapies to delay and/or prevent aging and age-related diseases in people.

Publications

  1. Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation. Sci Adv. 2023 01 13; 9(2):eadd2743. View Abstract
  2. Refining Convergent Rate Analysis with Topology in Mammalian Longevity and Marine Transitions. Mol Biol Evol. 2021 10 27; 38(11):5190-5203. View Abstract
  3. Footprints in the Sand: Deep Taxonomic Comparisons in Vertebrate Genomics to Unveil the Genetic Programs of Human Longevity. Front Genet. 2021; 12:678073. View Abstract
  4. Notochordal Signals Establish Phylogenetic Identity of the Teleost Spine. Curr Biol. 2020 07 20; 30(14):2805-2814.e3. View Abstract
  5. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. Elife. 2020 01 27; 9. View Abstract
  6. Longevity and GAPDH Stability in Bivalves and Mammals: A Convenient Marker for Comparative Gerontology and Proteostasis. PLoS One. 2015; 10(11):e0143680. View Abstract
  7. Superior proteome stability in the longest lived animal. Age (Dordr). 2014 Jun; 36(3):9597. View Abstract
  8. Rapamycin extends life and health in C57BL/6 mice. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):119-30. View Abstract
  9. Efficient derivation of embryonic stem cells from nuclear transfer and parthenogenetic embryos derived from cryopreserved oocytes. Cell Reprogram. 2010 Apr; 12(2):203-11. View Abstract

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