The Trista North Lab focuses on developmental hematopoiesis as a key to uncovering general principles of stem cell function, self-renewal and tissue regeneration.   Overview Hematopoietic stem cells (HSCs) give rise to each of the blood cell lineages …

Researchers at the Walsh Laboratory study the genetics and molecular biology of the developing cerebral cortex, the brain's largest structure, to advance the understanding, diagnosis and management of human neurological disease. Please visit the Walsh …

Contact Learn more Our Lab Learn more Our Research Learn more Much of the research in the Ploegh lab is in the fields of biochemistry and immunology, which started with a specific focus on unraveling the mechanisms by which MHC molecules interact with …

  The prevalence of obesity is rising at alarming rates in our nation, even in our children.  Yet, we still do not understand how, or even if, obesity causes the many disorders associated with it.   The mission of the Biddinger Laboratory is to define the …

Study Details   Why is this study being conducted? Despite technological advances, glucose control remains suboptimal in people with type 1 diabetes . Diet plays an important role in diabetes management, and some foods have a bigger effect on blood …

  Clonal analysis of hematopoietic stem cell biology: Tremendous progress has been achieved in the characterization of the hematopoietic system over the past two decades. Historically, the main experimental approach used to elucidate and define these …

  Evolution of self-reactive B cells  Using a novel mixed bone marrow lupus model, we found that self-reactive B cells can escape tolerance and form germinal centers much like those specific for foreign antigen. Remarkably, the self-reactive B cells not …

  Boston Children’s Hospital 200 Longwood Ave. Warren Albert Building, Room 251 Boston, MA 02115 Tel: 617-713-8700 Fax: 617-713-8702 Email: michael.carroll@childrens.harvard.edu  Open Positions Postdoctoral positions available in: neuro immunology …

  Project One: Nuclear receptor mediated ocular neovascularization and inflammation This project investigates the role of nuclear receptors, specifically a lipid-sensing nuclear receptor RORalpha as a transcriptional regulator of ocular angiogenesis and …

In every new discovery that we make, through every step forward, we depend upon children and families who support our work by participating in our studies. Your involvement could provide us with valuable insight and can also be a fun, educational …