Lab Members

Principal Investigator

Dongwon Lee, PhD | Principal Investigator

Dongwon is an assistant professor of Pediatrics in the Division of Nephrology at Boston Children's Hospital and Harvard Medical School. He is affiliated with the Manton Center for Orphan Disease Research and is an associate member of the Broad Institute of MIT and Harvard. Additionally, he is a faculty member of the Harvard Bioinformatics and Integrative Genomics (BIG) PhD Program.

Trained as a computational biologist and human geneticist with expertise in machine learning, he is specifically interested in how transcriptional dysregulation affects human diseases, specifically focusing on pediatric kidney diseases. Dongwon seeks to better understand the underlying genetic mechanisms of these diseases and believes we can make a significant breakthrough with our single-cell multi-omic approaches combined with machine- learning techniques.

Lab Members

	Anya Greenberg, BS \| Computational Biologist Anya is a computational biologist specializing in genome-wide association studies (GWAS) and gene regulation to decipher the genomic basis of pediatric kidney diseases. She is concurrently pursuing a Master’s degree in Computational Biology and Quantitative Genetics at Harvard T.H. Chan School of Public Health. During her undergraduate studies at the University of Rochester, Anya worked in Dr. Amanda Larracuente’s evolutionary genomics lab studying repetitive DNA profiles using data visualization and machine learning.
	Jeerthi Kannan, MS \| Computational Biologist Jeerthi is a research assistant with experience in computational biology, genomics, machine learning, and AI. While attending the University of Rochester and Vanderbilt University, she has used feature identification, visualization, and analysis to inform outcomes in biomedical research projects. She seeks to utilize additional computational methods to contribute towards further understanding of pediatric kidney diseases.
	Yangyang Lin, BS \| Research Assistant Yangyang is a research assistant driven by a passion for discovering the complexities of DNA variants using computational tools. Her current work focuses on developing machine learning models to understand how Allele-Specific Accessibility variants affect gene regulation activities. She is continually learning the intricacies of DNA and exploring advanced computational tools to decode these complexities and their implications on human health. Alongside this, Yangyang is actively gaining research experience to prepare for her future goals in the field, aiming to contribute meaningfully to the intersection of computational science and genomics.
	Daniel Nguyen, BS \| Research Assistant Daniel is a Research Assistant studying single-cell multiomic data regarding nephrotic diseases. He completed his Bachelor’s in Computational Biology and Mathematical Science at Colby College. As an undergraduate, Daniel worked with Professor Alexandra Howell’s Lab at Dartmouth College studying a novel CRISPR-Cas system for gene therapeutics, and Chesler Lab at Jackson Laboratory working on multi-modal data integrating algorithms to gain insights into substance use disorders.
	Eric Sakkas, BS \| Research Assistant Eric Sakkas graduated from Wesleyan University with a degree in Molecular Biology & Biochemistry and Computer Science. His thesis involved the development of software to observe allosteric changes in ribosomes. In the Lee Lab, Eric works on enhancing allele-specific expression analyses by incorporating filtered whole-genome sequencing data.

Alumni

Seong Kyu Han, PhD | Postdoctoral Fellow, currently Assistant Professor, Department of Biological Sciences, Inha University, South Korea

Ana Onuchic-Whitford, MD | Research Fellow, currently Instructor, Harvard School of Medicine and Nephrologist, Brigham and Women's Hospital

Jihoon Yoon, MD, PhD | Research Associate, currently Clinical Fellow, Department of Genomic Medicine, Seoul National University Hospital, South Korea

Parsa Seyfourian, BS | Student Intern, currently Masters Student, Bioinformatics, University of British Columbia

	Anya Greenberg, BS \| Computational Biologist Anya is a computational biologist specializing in genome-wide association studies (GWAS) and gene regulation to decipher the genomic basis of pediatric kidney diseases. She is concurrently pursuing a Master’s degree in Computational Biology and Quantitative Genetics at Harvard T.H. Chan School of Public Health. During her undergraduate studies at the University of Rochester, Anya worked in Dr. Amanda Larracuente’s evolutionary genomics lab studying repetitive DNA profiles using data visualization and machine learning.
	Jeerthi Kannan, MS \| Computational Biologist Jeerthi is a research assistant with experience in computational biology, genomics, machine learning, and AI. While attending the University of Rochester and Vanderbilt University, she has used feature identification, visualization, and analysis to inform outcomes in biomedical research projects. She seeks to utilize additional computational methods to contribute towards further understanding of pediatric kidney diseases.
	Yangyang Lin, BS \| Research Assistant Yangyang is a research assistant driven by a passion for discovering the complexities of DNA variants using computational tools. Her current work focuses on developing machine learning models to understand how Allele-Specific Accessibility variants affect gene regulation activities. She is continually learning the intricacies of DNA and exploring advanced computational tools to decode these complexities and their implications on human health. Alongside this, Yangyang is actively gaining research experience to prepare for her future goals in the field, aiming to contribute meaningfully to the intersection of computational science and genomics.
	Daniel Nguyen, BS \| Research Assistant Daniel is a Research Assistant studying single-cell multiomic data regarding nephrotic diseases. He completed his Bachelor’s in Computational Biology and Mathematical Science at Colby College. As an undergraduate, Daniel worked with Professor Alexandra Howell’s Lab at Dartmouth College studying a novel CRISPR-Cas system for gene therapeutics, and Chesler Lab at Jackson Laboratory working on multi-modal data integrating algorithms to gain insights into substance use disorders.
	Eric Sakkas, BS \| Research Assistant Eric Sakkas graduated from Wesleyan University with a degree in Molecular Biology & Biochemistry and Computer Science. His thesis involved the development of software to observe allosteric changes in ribosomes. In the Lee Lab, Eric works on enhancing allele-specific expression analyses by incorporating filtered whole-genome sequencing data.

Dongwon Lee Lab | Lab Members

Principal Investigator

Alumni