Luo Laboratory Publications | Overview
(last updated: 3/09/2015)
2015
75. Kwak, H.J., P. Liu, B. Bajrami, Y. Xu, S.Y. Park, C. Nombela-Arrieta, S. Mondal, Y. Sun, H. Zhu, L. Chai, L.E. Silberstein, T. Cheng, and H.R. Luo (2015), Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity. 42(1): p. 159-71. PMCID: PMC4303526.
74. Zhao, F., J. Li, N. Zhou, J. Sakai, Y. Gao, J. Shi, B. Goldman, H.M. Browdy, H.R. Luo, and B. Xu (2014), De novo chemoattractants form supramolecular hydrogels for immunomodulating neutrophils in vivo. Bioconjug Chem. 25(12): p. 2116-22.
73. Proteinase 3 and Serpin B1: a novel pathway in the regulation of caspase-3 activation, neutrophil spontaneous apoptosis, and inflammation. Fabien Loison, Yuanfu Xu and Hongbo R Luo. Inflammation & Cell Signaling; 1: e462.
72. Luo, H.R. and S. Mondal (2015), Molecular control of PtdIns(3,4,5)P3 signaling in neutrophils. EMBO Rep. 16(2): p. 149-163.
2014
71. Fabien Loison, Haiyan Zhu, Kutay Karatepe, Anongnard Kasorn, Peng Liu, Keqiang Ye, Dieter E. Jenne, Eileen Remold-O’Donnell, Yuanfu Xu, Hongbo R. Luo*. Regulation of neutrophil death and inflammation by Proteinase 3. The Journal of Clinical Investigation. 2014. 124(10): p. 4445-58.
70. Luo, H.R., A dual regulator of neutrophil recruitment. Blood, 2014. 123(13): p. 1983-5
69. Jo, H., F. Loison, and H.R. Luo, Microtubule dynamics regulates Akt signaling via dynactin p150. Cell Signal, 2014. 1873-3913.
68. Stygelbout, V., K. Leroy, V. Pouillon, K. Ando, E. D'Amico, Y. Jia, H.R. Luo, C. Duyckaerts, C. Erneux, S. Schurmans, and J.P. Brion, Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology. Brain, 2014. 137(Pt 2): p. 537-52.
67. Wang, X., A.L. Robertson, J. Li, R.J. Chai, W. Haishan, P. Sadiku, N.V. Ogryzko, M. Everett, K. Yoganathan, H.R. Luo, S.A. Renshaw, and P.W. Ingham, Inhibitors of neutrophil recruitment identified using transgenic zebrafish to screen a natural product library. Dis Model Mech, 2014. 7(1): p. 163-9.
66. Ma, L., H. Gong, H. Zhu, Q. Ji, P. Su, P. Liu, S. Cao, J. Yao, L. Jiang, M. Han, X. Ma, D. Xiong, H.R. Luo, F. Wang, J. Zhou, and Y. Xu, A Novel Small-molecule TNFalpha Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model. J Biol Chem, 2014.
2013
65. Olin D. Liang, Jiayun Lu, César Nombela-Arrieta, Jia Zhong, Li Zhao, Gregory Pivarnik, Subhanjan Mondal, Li Chai, Leslie E. Silberstein, and Hongbo R. Luo. (2013). Deficiency of Lipid Phosphatase SHIP Enables Long Term Reconstitution of Hematopoietic Inductive Bone Marrow Microenvironment. Developmental Cell. 2013. 25(4):333-49.
64. Xu, Y., Li, H., Bajrami, B., Kwak, H., Cao, S., Liu, P., Zhou, J., Zhou, Y., Zhu, H., Ye, K., and Luo, H.R. (2013). Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proc Natl Acad Sci U S A. 110(19):7726-31.
63. Gao, C., Dimitrov, T., Yong, K.J., Tatetsu, H., Jeong, H.W., Luo, H.R., Bradner, J.E., Tenen, D.G., and Chai, L. (2013). Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood 121, 1413-1421. 1528-0020.
62. Liu, X., Qi, Q., Xiao, G., Li, J., Luo, H.R., and Ye, K. (2013). O-Methylated Metabolite of 7,8-Dihydroxyflavone Activates TrkB Receptor and Displays Antidepressant Activity. Pharmacology 91, 185-200.
61. He, K., Q. Qi, C.B. Chan, G. Xiao, X. Liu, C. Tucker-Burden, L. Wang, H. Mao, X. Lu, F.E. McDonald, H. Luo, Q.W. Fan, W.A. Weiss, S.Y. Sun, D.J. Brat, and K. Ye (2013). Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2. Sci Signal, 6(283): 1937-9145.
2012
60. Sakai, J., Li, J., Subramanian, K.K., Mondal, S., Bajrami, B., Hattori, H., Jia, Y., Dickinson, B.C., Zhong, J., Ye, K., Chang, C.J., Ho, Y.S., Zhou, J., and Luo, H.R. (2012). Reactive oxygen species (ROS)-induced actin glutathionylation and its modulation by glutaredoxin 1 are key physiological regulatory mechanisms controlling actin dynamics in neutrophils. Immunity 37, 1037-1049.
59. Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS. Leukotriene b4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19;37(4):747-58.
58. Liu, Xia; Chan, Chi Bun; Qi, Qi; Xiao, Ge; Luo, Hongbo; He, Xiaolin; Ye, Keqiang. Optimization of a Small Tropomyosin-related Kinase B (TrkB) Agonist 7,8-dihydroxyflavone Active in Mouse Models of Depression. Journal of Medicinal Chemistry. 55, 8524-8537.
57. Takizawa, S., Nagata, E., and Luo, H.R. (2012). [Novel neuroprotective agents: a HIF activator and an Akt activator]. Rinsho Shinkeigaku 52, 911-912.
56. Jo, H., Mondal, S., Tan, D., Nagata, E., Takizawa, S., Sharma, A.K., Hou, Q., Shanmugasundaram, K., Prasad, A., Tung, J.K., Tejeda, A.O., Man, H., Rigby, A.C., and Luo, H.R. (2012). Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A 109, 10581-10586. PMCID: PMC3387065
55. Lu, J., Y. Sun, C. Nombela-Arrieta, K.P. Du, S.Y. Park, L. Chai, C. Walkley, H.R. Luo, and L.E. Silberstein. Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Exp Hematol, 2012. 40(4): p. 307-17. PMCID:PMC3307834
54. Mondal, S., K.K. Subramanian, J. Sakai, B. Bajrami, and H.R. Luo. Phosphoinositide lipid phosphatase SHIP1 and PTEN coordinate to regulate cell migration and adhesion. Mol Biol Cell, 2012. 23(7): p. 1219-30. PMCID:PMC3315799
53. Wu, L.J., G. Wu, M.R. Akhavan Sharif, A. Baker, Y. Jia, F.H. Fahey, H.R. Luo, E.P. Feener, and D.E. Clapham. The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke. Nature Neuroscience, 2012. 15(4): p. 565-73. PMCID: PMC3314139
52. Jo, H. and H.R. Luo, Exploiting effectors of Rac GTPase. Chem Biol, 2012. 19(2): p. 169-71. PMCID:PMC3292760.
2011
51. Prasad, A., Jia, Y., Chakraborty, A., Li, Y., Jain, S.K., Zhong, J., Roy, S.G., Loison, L., Mondal, S., Sakai, J., Blanchard, C., Snyder, S.H., and Luo, H.R. (2011). Inositol hexakisphosphate kinase 1 (InsP6K1) regulates neutrophil function in innate immunity by inhibiting PtdIns(3,4,5)P3 signaling. Nature Immunology, 12(8): p. 752-60.
50. Mondal, S., S. Ghosh-Roy, F. Loison, Y. Li, Y. Jia, C. Harris, D.A. Williams, and H.R. Luo, PTEN negatively regulates engulfment of apoptotic cells by modulating activation of Rac GTPase. J Immunol, 2011. 187(11): p. 5783-94.
49. Chi Bun Chan, Xia liu, Sompol Pradoldej, Chunhai Hao, Jie An, Manuel Yepes, Hongbo R. Luo & Keqiang Ye. PIKE Regulates Neuronal Dendritogenesis and Survival in Neocortex. J Neurosci, 31(22): p. 8083-92.
48. Jo, H., Lo, P.K., Li, Y., Loison, F., Green, S., Wang, J., Silberstein, L.E., Ye, K., Chen, H., and Luo, H.R. (2011). Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A 108, 6486-6491.
47. He, K., C.B. Chan, X. Liu, Y. Jia, H.R. Luo, S.A. France, Y. Liu, W.D. Wilson, and K. Ye, Identification of a molecular activator for insulin receptor with potent anti-diabetic effects. J Biol Chem, 2011. 286(43): p. 37379-88.
46. Li, Y., Prasad, A., Jia, Y., Ghosh Roy, S., Loison, F., Mondal, S., Kocjan, P., Silberstein, L.E., Ding, S., and Luo, H.R. (2011). Pre-treatment with PTEN inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood. 117(24): p. 6702-13.
45. Sanchez-Aguilera, A., Lee, Y.J., Lo Celso, C., Ferraro, F., Brumme, K., Mondal, S., Kim, C., Dorrance, A., Luo, H.R., Scadden, D.T., and Williams, D.A. (2011). Guanine nucleotide exchange factor Vav1 regulates perivascular homing and bone marrow retention of hematopoietic stem and progenitor cells. Proc Natl Acad Sci U S A. 108, 9607-9612.
44. Subhanjan Mondal and Hongbo R. Luo (2011). Regulation of neutrophil function by tumor suppressor PTEN. In Tumor Suppressors (Nova Science Publishers, Inc.).
43. Liu, X., C.B. Chan, S.W. Jang, S. Pradoldej, J. Huang, K. He, L.H. Phun, S. France, G. Xiao, Y. Jia, H.R. Luo, and K. Ye (2011). A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect. J Med Chem, 2011. 1520-4804.
2010
42. Carbo, C., Duerschmied, D., Goerge, T., Hattori, H., Sakai, J., Cifuni, S.M., White, G.C., 2nd, Chrzanowska-Wodnicka, M., Luo, H.R., and Wagner, D.D. (2010). Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis. J Leukoc Biol 88, 313-319.
41. Chan, C.B., Liu, X., Jung, D.Y., Jun, J.Y., Luo, H.R., Kim, J.K., and Ye, K. (2010). Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance. Diabetes 59, 883-893.
40. Hattori, H., Subramanian, K.K., Sakai, J., Jia, Y., Li, Y., Porter, T.F., Loison, F., Sarraj, B., Kasorn, A., Jo, H., Blanchard, C., Zirkle, D., McDonald, D., Pai, S.Y., Serhan, C.N., and Luo, H.R. (2010). Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A 107, 3546-3551.
39. Hattori, H., Subramanian, K.K., Sakai, J., and Luo, H.R. (2010). Reactive oxygen species as signaling molecules in neutrophil chemotaxis. Commun Integr Biol 3, 278-281.
38. Jo, H., Loison, F., Hattori, H., Silberstein, L.E., Yu, H., and Luo, H.R. (2010). Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One 5, e10318.
37. Luo, H.R., and Bajrami, B. (2010). Regulation of neutrophil homeostasis by spontaneous apoptotic death. In Neutrophils: Lifespan, Functions and Roles in Disease (Nova Science Publishers, Inc.).
36. Oh, S.M., Liu, Z., Okada, M., Jang, S.W., Liu, X., Chan, C.B., Luo, H., and Ye, K. (2010). Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. Oncogene 29, 1017-1030.
35. Simarro, M., Giannattasio, G., De la Fuente, M.A., Benarafa, C., Subramanian, K.K., Ishizawar, R., Balestrieri, B., Andersson, E.M., Luo, H.R., Orduna, A., Boyce, J., and Anderson, P. (2010). Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation. J Immunol 184, 5325-5332.
34. Xu, Y., Loison, F., and Luo, H.R. (2010). Neutrophil spontaneous death is mediated by down-regulation of autocrine signaling through GPCR, PI3Kgamma, ROS, and actin.Proc Natl Acad Sci U S A 107, 2950-2955.
33. Yu, H., Li, Y., Gao, C., Fabien, L., Jia, Y., Lu, J., Silberstein, L.E., Pinkus, G.S., Ye, K., Chai, L., and Luo, H.R. (2010). Relevant mouse model for human monocytic leukemia through Cre/lox-controlled myeloid-specific deletion of PTEN. Leukemia 24, 1077-1080.
2009
32. Kasorn, A., Alcaide, P., Jia, Y., Subramanian, K. K., Sarraj, B., Li, Y., Loison, F., Hattori, H., Silberstein, L. E., Luscinskas, W. F., and Luo, H. R. (2009). Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals. J Immunol 183, 1032-1043
31. Li, Y., Jia, Y., Pichavant, M., Loison, F., Sarraj, B., Kasorn, A., You, J., Robson, B. E., Umetsu, D. T., Mizgerd, J. P., Ye K., and Luo, H. R. (2009). Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood 113, 4930-4941.
30. Lu, J., Jeong, H., Kong, N., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., Yupoma, and Chai, L. (2009). Stem cell factor SALL4 represses the transcriptions of PTEN and SALL1 through an epigenetic repressor complex. PLoS One 4, e5577.
29. Sarraj, B., Massberg, S., Li, Y., Kasorn, A., Subramanian, K., Loison, F., Silberstein, L. E., von Andrian, U., and Luo, H. R. (2009). Myeloid-specific deletion of tumor suppressor PTEN augments neutrophil transendothelial migration during inflammation. J Immunol 182, 7190-7200.
28. Subramanian, K. K., and Luo, H. R. (2009). Non-classical roles of NADPH-oxidase dependent Reactive Oxygen Species in Phagocytes, In Granulocytes: Classification, Toxic Materials Produced and Pathology, F. Columbus, ed. (Nova Science Publishers, Inc.).
27. Loison, F and Luo, HR. Granulocyte apoptosis and its involvement in inflammation/infection. Modern Insights Into Disease From Molecules to Man.Apoptosis. Science Publishers 2009.
2008
26. Hakryul Jo, Yonghui Jia, Kulandayan K. Subramanian, Hidenori Hattori, and Hongbo R. Luo (2008). Cancer cell-derived Clusterin and IGF-1 constitute a regulatory system for the PI3K-Akt pathway. Mol Cell Biol. 28: 4285-4299.
25. Yonghui Jia, Stephane Schurmans, and Hongbo R. Luo. Regulation of innate immunity by inositol 1,3,4,5-tetrakisphosphate. Cell Cycle 2008;7(18):2803-8.
24. Zhixue Liu, Sung-Wuk Jang, Xia Liu, Dongmei Cheng, Junmin Peng, Xiao-jiang Li, Steve Matthews, Colin Watts, Masahide Asano, Ikuko Hara-Nishimura, Hongbo R. Luo, and Keqiang Ye (2008). Legumain Activation Triggers SET Proteolytic Cleavage and Neuronal Injury in Brain. Molecular Cell. 29: 665-678.
23. Jia, Y., F. Loison, H. Hattori, Y. Li, C. Erneux, S. Y. Park, C. Gao, L. Chai, L. E. Silberstein, S. Schurmans, and H. R. Luo (2008). Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis. Proc Natl Acad Sci U S A105: 4739-4744.
22. Hongbo R. Luo and Fabien Loison. Constitutive neutrophil apoptosis: mechanisms and regulation (invited review). Am J Hematol. 2008 Apr;83(4):288-95.
2007
21. Yonghui Jia, Kulandayan K. Subramanian, Christophe Erneux, Valerie Pouillon, Hidenori Hattori, Hakryul Jo, Jian You, Daocheng Zhu, Stephane Schurmans, and Hongbo R. Luo (2007). Inositol 1,3,4,5-tetrakisphosphate negatively regulates chemoattractant-elicited PtdIns(3,4,5)P3 signaling in neutrophils. Immunity 27: 453-467.
20. Yi Le, Bingmei Zhu, Brendan Harley, Shin-Young Park, John P. Manis, Hongbo R. Luo, A. Yoshimura, L. Hennighausen and L. Silberstein (2007). Developmental regulation of CXCR4-FAK signaling by SOCS3 during B lymphopoiesis. Immunity 27(5):811-23.
19. Marechal, Y., X. Pesesse, Y. Jia, V. Pouillon, D. Perez-Morga, J. Daniel, S. Izui, P. J. Cullen, O. Leo, H. R. Luo, C. Erneux, and S. Schurmans. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells (2007). Proc Natl Acad Sci U S A 104: 13978-13983.
18. Hattori, H., X. Zhang, Y. Jia, K. K. Subramanian, H. Jo, F. Loison, P. E. Newburger, and H. R. Luo (2007). RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. Blood 110: 640-650.
17. Subramanian, K. K., Jia, Y., Jo, H., Loison, F., You, J., Benjamin T. Simms E.J, Mizgerd J.P, and Luo, H. R. Tumor suppressor PTEN is a physiological suppressor of neutrophil function. Blood 2007 109: 4028-4037.
16. Huang, Y., B. N. Kang, J. Tian, Y. Liu, H. R. Luo, L. Hester, and S. H. Snyder (2007). The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. J Neurosci 27: 449-458.
2006
15. Zhu, D., H. Hattori, H. Jo, Y. Jia, K. K. Subramanian, F. Loison, J. You, Y. Le, M. Honczarenko, L. Silberstein, and H. R. Luo (2006). Deactivation of phosphatidylinositol 3,4,5-trisphosphate/Akt signaling mediates neutrophil spontaneous death. Proc Natl Acad Sci U S A 103: 14836-14841.
2005
14. Huang, Y., H. Y. Man, Y. Sekine-Aizawa, Y. Han, K. Juluri, H. Luo, J. Cheah, C. Lowenstein, R. L. Huganir, and S. H. Snyder (2005). S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron 46: 533-540.
13. Nagata, E.*, H. R. Luo*, A. Saiardi, B. I. Bae, N. Suzuki, and S. H. Snyder (2005). Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem280: 1634-1640. (*, these authors contributed equally)
1999-2004
12. Iijima, M., Y. E. Huang, H. R. Luo, F. Vazquez, and P. N. Devreotes (2004). Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis. J Biol Chem 279: 16606-16613.
11. Luo, H. R., H. Hattori, M. A. Hossain, L. Hester, Y. Huang, W. Lee-Kwon, M. Donowitz, E. Nagata, and S. H. Snyder (2003). Akt as a mediator of cell death. Proc Natl Acad Sci U S A 100: 11712-11717.
10. Luo, H. R., Y. E. Huang, J. C. Chen, A. Saiardi, M. Iijima, K. Ye, Y. Huang, E. Nagata, P. Devreotes, and S. H. Snyder (2003). Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 114: 559-572.
9. Luo, H. R., A. Saiardi, H. Yu, E. Nagata, K. Ye, and S. H. Snyder (2002). Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast. Biochemistry 41: 2509-2515.
8. Ye, K., B. Aghdasi, H. R. Luo, J. L. Moriarity, F. Y. Wu, J. J. Hong, K. J. Hurt, S. S. Bae, P. G. Suh, and S. H. Snyder (2002). Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE. Nature 415: 541-544.
7. Luo, H. R., A. Saiardi, E. Nagata, K. Ye, H. Yu, T. S. Jung, X. Luo, S. Jain, A. Sawa, and S. H. Snyder (2001). GRAB: a physiologic guanine nucleotide exchange factor for Rab3A, which interacts with inositol hexakisphosphate kinase. Neuron 31: 439-451.
6. Saiardi, A., E. Nagata, H. R. Luo, A. Sawa, X. Luo, A. M. Snowman, and S. H. Snyder (2001). Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate. Proc Natl Acad Sci U S A 98: 2306-2311.
5. Saiardi, A., E. Nagata, H. R. Luo, A. M. Snowman, and S. H. Snyder (2001). Identification and characterization of a novel inositol hexakisphosphate kinase. J Biol Chem 276: 39179-39185.
4. Lai, M. M., H. R. Luo, P. E. Burnett, J. J. Hong, and S. H. Snyder (2000). The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. J Biol Chem 275: 34017-34020.
3. Ye, K., K. J. Hurt, F. Y. Wu, M. Fang, H. R. Luo, J. J. Hong, S. Blackshaw, C. D. Ferris, and S. H. Snyder (2000). Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N. Cell 103: 919-930.
2. Luo, H. R., G. A. Moreau, N. Levin, and M. J. Moore (1999). The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes. RNA 5: 893-908.
1. Reyes, J. L., E. H. Gustafson, H. R. Luo, M. J. Moore, and M. M. Konarska (1999). The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site. RNA 5: 167-179.