Christina Jacobsen | Medical Services
Specialties
Programs & Services
Languages
- English
Christina Jacobsen | Education
Medical School
Washington University School of Medicine
2005, St. Louis, MO
Internship
Pediatrics
Boston Children's Hospital
2006, Boston, MA
Residency
Pediatrics
Boston Children's Hospital
2007, Boston, MA
Fellowship
Pediatric Endocrinology and Genetics
Harvard Medical School/Boston Children's Hospital
2011, Boston, MA
Christina Jacobsen | Certifications
- American Board of Medical Genetics and Genomics (Clinical Genetics)
- American Board of Pediatrics (Endocrinology)
- American Board of Pediatrics (General)
Christina Jacobsen | Professional History
Dr. Christina Jacobsen is a pediatric endocrinologist and geneticist with a particular interest in genetic bone diseases including osteogenesis imperfecta and skeletal dysplasia as well metabolic bone disease. She sees patients in Endocrinology and with the Orthopedic Surgeons in the Orthopedic clinic.
Christina Jacobsen | Publications
Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. NPJ Genom Med. 2024 Dec 02; 9(1):60. View Hospital-wide access to genomic data advanced pediatric rare disease research and clinical outcomes. Abstract
Case 21-2024: A 10-Month-Old Boy with Vomiting and Hypercalcemia. N Engl J Med. 2024 Jul 11; 391(2):167-176. View Case 21-2024: A 10-Month-Old Boy with Vomiting and Hypercalcemia. Abstract
Genetics of skeletal proportions in two different populations. bioRxiv. 2023 May 30. View Genetics of skeletal proportions in two different populations. Abstract
4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta. J Bone Miner Res. 2022 04; 37(4):675-686. View 4-PBA Treatment Improves Bone Phenotypes in the Aga2 Mouse Model of Osteogenesis Imperfecta. Abstract
Prospective phenotyping of long-term survivors of generalized arterial calcification of infancy (GACI). Genet Med. 2021 02; 23(2):396-407. View Prospective phenotyping of long-term survivors of generalized arterial calcification of infancy (GACI). Abstract
Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells. J Bone Miner Res. 2020 10; 35(10):1981-1991. View Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells. Abstract
Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. J Clin Endocrinol Metab. 2020 05 01; 105(5). View Insight Into the Ontogeny of GnRH Neurons From Patients Born Without a Nose. Abstract
Combination therapy in the Col1a2G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFß signaling on trabecular bone but not on cortical bone. Bone. 2020 02; 131:115084. View Combination therapy in the Col1a2G610C mouse model of Osteogenesis Imperfecta reveals an additive effect of enhancing LRP5 signaling and inhibiting TGFß signaling on trabecular bone but not on cortical bone. Abstract
Retinoic-acid-induced osteogenesis of hiPSCs. Nat Biomed Eng. 2019 07; 3(7):504-506. View Retinoic-acid-induced osteogenesis of hiPSCs. Abstract
The Outcomes of Nonelongating Intramedullary Fixation of the Lower Extremity for Pediatric Osteogenesis Imperfecta Patients: A Meta-analysis. J Pediatr Orthop. 2017 Jul/Aug; 37(5):e313-e316. View The Outcomes of Nonelongating Intramedullary Fixation of the Lower Extremity for Pediatric Osteogenesis Imperfecta Patients: A Meta-analysis. Abstract
SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Nat Genet. 2017 Feb; 49(2):238-248. View SMCHD1 mutations associated with a rare muscular dystrophy can also cause isolated arhinia and Bosma arhinia microphthalmia syndrome. Abstract
Application of anti-Sclerostin therapy in non-osteoporosis disease models. Bone. 2017 03; 96:18-23. View Application of anti-Sclerostin therapy in non-osteoporosis disease models. Abstract
Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta. Bone. 2016 09; 90:127-32. View Enhanced Wnt signaling improves bone mass and strength, but not brittleness, in the Col1a1(+/mov13) mouse model of type I Osteogenesis Imperfecta. Abstract
Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta. Bone. 2016 06; 87:120-9. View Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta. Abstract
Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature. Hum Mutat. 2015 Apr; 36(4):474-81. View Heterozygous mutations in natriuretic peptide receptor-B (NPR2) gene as a cause of short stature. Abstract
Reply to Lrp5 regulation of bone mass and gut serotonin synthesis. Nat Med. 2014 Nov; 20(11):1229-30. View Reply to Lrp5 regulation of bone mass and gut serotonin synthesis. Abstract
Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta. J Bone Miner Res. 2014 Oct; 29(10):2297-306. View Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta. Abstract
Copy number variation plays an important role in clinical epilepsy. Ann Neurol. 2014 Jun; 75(6):943-58. View Copy number variation plays an important role in clinical epilepsy. Abstract
Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations. J Clin Endocrinol Metab. 2014 Aug; 99(8):E1510-8. View Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations. Abstract
Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome. Sci Transl Med. 2013 Nov 13; 5(211):211ra158. View Sclerostin inhibition reverses skeletal fragility in an Lrp5-deficient mouse model of OPPG syndrome. Abstract
An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. J Bone Miner Res. 2013 Oct; 28(10):2081-93. View An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations. Abstract
Proximal tibial pain in a child. Skeletal Radiol. 2013 Sep; 42(9):1333-6. View Proximal tibial pain in a child. Abstract
Proximal tibial pain in a child. Skeletal Radiol. 2013 Sep; 42(9):1297-9, 1333-6. View Proximal tibial pain in a child. Abstract
Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun; 17(6):684-91. View Lrp5 functions in bone to regulate bone mass. Abstract
Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium. J Clin Endocrinol Metab. 2010 Sep; 95(9):4184-91. View Impact of heterozygosity for acid-labile subunit (IGFALS) gene mutations on stature: results from the international acid-labile subunit consortium. Abstract
Craniocerebral trauma--congruence between post-mortem computed tomography diagnoses and autopsy results: a 2-year retrospective study. Forensic Sci Int. 2010 Jan 30; 194(1-3):9-14. View Craniocerebral trauma--congruence between post-mortem computed tomography diagnoses and autopsy results: a 2-year retrospective study. Abstract
Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. Horm Res. 2009; 71(2):100-10. View Three novel IGFALS gene mutations resulting in total ALS and severe circulating IGF-I/IGFBP-3 deficiency in children of different ethnic origins. Abstract
Short stature in a phenotypic male caused by mixed gonadal dysgenesis. Nat Clin Pract Endocrinol Metab. 2008 Sep; 4(9):524-8. View Short stature in a phenotypic male caused by mixed gonadal dysgenesis. Abstract
GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Dev Dyn. 2005 Oct; 234(2):355-62. View GATA-4:FOG interactions regulate gastric epithelial development in the mouse. Abstract
Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Mol Cell Endocrinol. 2004 Oct 29; 226(1-2):51-7. View Transcription factor GATA-6 is expressed in the endocrine and GATA-4 in the exocrine pancreas. Abstract
GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004 Nov; 287(5):G1086-99. View GATA-4, GATA-5, and GATA-6 activate the rat liver fatty acid binding protein gene in concert with HNF-1alpha. Abstract
Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Dev Biol. 2002 Jan 01; 241(1):34-46. View Genetic mosaic analysis reveals that GATA-4 is required for proper differentiation of mouse gastric epithelium. Abstract