Current Environment: Production

Douglas McDonald | Education

Undergraduate School

Pennsylvania State University

State College, PA

Graduate School

Case Western Reserve University School of Medicine

Cleveland, OH

Medical School

Case Western Reserve University School of Medicine

Cleveland, OH

Internship

Cincinnati Children's Hospital

Cincinnati, OH

Residency

Cincinnati Children's Hospital

Cincinnati, OH

Fellowship

Allergy and Immunology

Boston Children's Hospital

Boston, MA

Douglas McDonald | Certifications

  • American Board of Allergy & Immunology (General)

Douglas McDonald | Publications

  1. The role of dupilumab in the treatment of eosinophilic esophagitis. Immunotherapy. 2024; 16(13):845-852. View The role of dupilumab in the treatment of eosinophilic esophagitis. Abstract

  2. A Novel Combination of Compound Heterozygous Variants in IFNGR1 Causing Complete IFNGR1 Deficiency. J Clin Immunol. 2024 04 27; 44(5):111. View A Novel Combination of Compound Heterozygous Variants in IFNGR1 Causing Complete IFNGR1 Deficiency. Abstract

  3. Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2022 May; 23(5):815. View Author Correction: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Abstract

  4. Inborn Errors of the Immune System Associated With Atopy. Front Immunol. 2022; 13:860821. View Inborn Errors of the Immune System Associated With Atopy. Abstract

  5. Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. J Allergy Clin Immunol. 2020 11; 146(5):1194-1200.e1. View Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1. Abstract

  6. Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Clin Immunol. 2020 07; 216:108459. View Immunoglobulins in the treatment of COVID-19 infection: Proceed with caution! Abstract

  7. RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. J Allergy Clin Immunol. 2020 06; 145(6):1673-1680.e11. View RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness. Abstract

  8. Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. Clin Rev Allergy Immunol. 2019 Oct; 57(2):213-225. View Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. Abstract

  9. Oral viscous mometasone is an effective treatment for eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2020 Mar; 8(3):1107-1109. View Oral viscous mometasone is an effective treatment for eosinophilic esophagitis. Abstract

  10. Defective TLR9-driven STAT3 activation in B cells of patients with CVID. Clin Immunol. 2018 12; 197:40-44. View Defective TLR9-driven STAT3 activation in B cells of patients with CVID. Abstract

  11. Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2016 09; 138(3):852-859.e3. View Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency. Abstract

  12. Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. J Allergy Clin Immunol. 2014 Jun; 133(6):1753-5.e3. View Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-a 2b therapy. Abstract

  13. Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. J Allergy Clin Immunol. 2014 Jul; 134(1):221-3. View Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency. Abstract

  14. Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. Spine J. 2012 Aug; 12(8):e1-6. View Intraoperative anaphylaxis to gelatin in topical hemostatic agents during anterior spinal fusion: a case report. Abstract

  15. DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Nat Immunol. 2012 May 13; 13(6):612-20. View DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation. Abstract

  16. TH17 deficiency in human disease. J Allergy Clin Immunol. 2012 Jun; 129(6):1429-35; quiz 1436-7. View TH17 deficiency in human disease. Abstract

  17. Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1304-5.e3. View Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency. Abstract

  18. Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Medicine (Baltimore). 2010 Nov; 89(6):403-425. View Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency. Abstract

  19. Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. J Allergy Clin Immunol. 2010 Aug; 126(2):332-7, 337.e1-2. View Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients. Abstract

  20. Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. J Allergy Clin Immunol. 2010 Jul; 126(1):127-32.e7. View Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene. Abstract

  21. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3546-51. View Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Abstract

  22. Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. J Allergy Clin Immunol. 2007 Oct; 120(4):900-7. View Heterozygous N-terminal deletion of IkappaBalpha results in functional nuclear factor kappaB haploinsufficiency, ectodermal dysplasia, and immune deficiency. Abstract

  23. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8. View Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. Abstract

  24. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J Exp Med. 2007 Oct 01; 204(10):2407-22. View Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. Abstract

  25. Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. J Allergy Clin Immunol. 2006 Dec; 118(6):1357-62. View Interleukin receptor-associated kinase-4 deficiency impairs Toll-like receptor-dependent innate antiviral immune responses. Abstract

  26. Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Microbes Infect. 2006 Apr; 8(4):1151-6. View Lessons learned from molecular defects in nuclear factor kappaB dependent signaling. Abstract

  27. RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. J Exp Med. 2004 Aug 02; 200(3):399-404. View RIP links TLR4 to Akt and is essential for cell survival in response to LPS stimulation. Abstract

  28. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. J Neurosci. 2003 Apr 01; 23(7):2665-74. View A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. Abstract

  29. beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. J Neurosci. 1998 Jun 15; 18(12):4451-60. View beta-Amyloid fibrils activate parallel mitogen-activated protein kinase pathways in microglia and THP1 monocytes. Abstract

  30. Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. J Neurosci. 1997 Apr 01; 17(7):2284-94. View Amyloid fibrils activate tyrosine kinase-dependent signaling and superoxide production in microglia. Abstract

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