Current Environment: Production

Medical Services

Specialties

Programs & Services

Languages

  • English

Education

Undergraduate School

Williams College

1980, Williamstown, MA, US

Medical School

Harvard Medical School

1987, Boston, MA, US

Internship

Boston Children's Hospital

1988, Boston, MA, US

Residency

Pediatrics

Boston Children's Hospital

1990, Boston, MA, US

Fellowship

Allergy & Immunology

Boston Children's Hospital

1993, Boston, MA

Certifications

  • American Board of Allergy & Immunology (General)

Professional History

Dr. Oettgen received his MD and PhD (Immunology) degrees from Harvard Medical School. He completed his clinical training in Pediatrics and in Allergy & Immunology at Boston Children’s Hospital followed by post-doctoral research training in Genetics at Harvard Medical School with Dr. Philip Leder. Dr. Oettgen joined the Children’s Hospital faculty in 1994, providing and care for children with allergic disorders and overseeing a research program on the regulation of allergic responses. He holds the Prince Turki Bin Abdul Aziz Al-Saud Professorship in Pediatrics at Harvard Medical School and serves as Deputy Chief of the Department of Pediatrics, Associate Chief of the Division of Immunology and Harvard Medical School Dean for Academic Programs at Boston Children’s Hospital.

Publications

  1. T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. Mucosal Immunol. 2025 Jan 15. View Abstract

  2. Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy. Front Allergy. 2024; 5:1389669. View Abstract

  3. Rethinking Immunological Risk: A Retrospective Cohort Study of Severe SARS-Cov-2 Infections in Individuals With Congenital Immunodeficiencies. J Allergy Clin Immunol Pract. 2023 11; 11(11):3391-3399.e3. View Abstract

  4. Rethinking immunologic risk: a retrospective cohort study of severe SARS-CoV-2 infections in individuals with congenital immunodeficiencies. medRxiv. 2023 Jun 05. View Abstract

  5. IgG:Fc?RIIb signals block effector programs of IgE:FceRI-activated mast cells but spare survival pathways. J Allergy Clin Immunol. 2023 08; 152(2):453-468. View Abstract

  6. Mast cells in food allergy: Inducing immediate reactions and shaping long-term immunity. J Allergy Clin Immunol. 2023 01; 151(1):21-25. View Abstract

  7. Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils. Front Immunol. 2022; 13:881655. View Abstract

  8. High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy. Cell Rep Med. 2021 10 19; 2(10):100410. View Abstract

  9. Immune changes beyond Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. Allergy. 2021 09; 76(9):2809-2826. View Abstract

  10. Mast Cells as Regulators of Adaptive Immune Responses in Food Allergy. Yale J Biol Med. 2020 12; 93(5):711-718. View Abstract

  11. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 Dec 15; 53(6):1331-1332. View Abstract

  12. IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy. Front Immunol. 2020; 11:603050. View Abstract

  13. Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation. Contemp Clin Trials. 2021 01; 100:106228. View Abstract

  14. IgE and mast cells: The endogenous adjuvant. Adv Immunol. 2020; 148:93-153. View Abstract

  15. Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 12 15; 53(6):1202-1214.e6. View Abstract

  16. Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. J Allergy Clin Immunol. 2020 10; 146(4):884-893.e5. View Abstract

  17. The soluble isoform of human Fc?RI is an endogenous inhibitor of IgE-mediated mast cell responses. Allergy. 2019 02; 74(2):236-245. View Abstract

  18. Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies. Ann Allergy Asthma Immunol. 2019 02; 122(2):213-215. View Abstract

  19. Tissue-Specific Expression of the Low-Affinity IgG Receptor, Fc?RIIb, on Human Mast Cells. Front Immunol. 2018; 9:1244. View Abstract

  20. Importance of basophils in eosinophilic asthma: the murine counterpart. J Biol Regul Homeost Agents. 2018 Mar-Apr; 32(2):335-339. View Abstract

  21. IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy. 2018 03; 48(3):288-296. View Abstract

  22. Food allergy. Nat Rev Dis Primers. 2018 01 04; 4:17098. View Abstract

  23. Pillars Article: The X-Linked Lymphoproliferative Disease Gene Product SAP Regulates Signals Induced through the Co-Receptor SLAM. Nature. 1998. 395: 462-469. J Immunol. 2017 09 01; 199(5):1534-1541. View Abstract

  24. Allergen-specific IgG antibody signaling through Fc?RIIb promotes food tolerance. J Allergy Clin Immunol. 2018 01; 141(1):189-201.e3. View Abstract

  25. A humanized mouse model of anaphylactic peanut allergy. J Allergy Clin Immunol. 2017 01; 139(1):314-322.e9. View Abstract

  26. Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases. J Allergy Clin Immunol. 2016 06; 137(6):1631-1645. View Abstract

  27. IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immunol. 2016 09; 138(3):801-811.e9. View Abstract

  28. IgE receptor signaling in food allergy pathogenesis. Curr Opin Immunol. 2015 Oct; 36:109-14. View Abstract

  29. IgE and Mast Cells: The Endogenous Adjuvant. Adv Immunol. 2015; 127:203-56. View Abstract

  30. Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy. Immunity. 2015 Mar 17; 42(3):512-23. View Abstract

  31. Polyclonal IgE Induces Mast Cell Survival and Cytokine Production. Allergol Int. 2009; 58(3):411-419. View Abstract

  32. Anti-IgE therapy: clinical utility and mechanistic insights. Curr Top Microbiol Immunol. 2015; 388:39-61. View Abstract

  33. Oral immunotherapy induces IgG antibodies that act through Fc?RIIb to suppress IgE-mediated hypersensitivity. J Allergy Clin Immunol. 2014 Dec; 134(6):1310-1317.e6. View Abstract

  34. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity. 2014 Jul 17; 41(1):141-51. View Abstract

  35. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17. View Abstract

  36. Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses. J Biol Regul Homeost Agents. 2014 Jan-Mar; 28(1):91-103. View Abstract

  37. IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum. Clin Immunol. 2014 Feb; 150(2):153-60. View Abstract

  38. An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis. Mol Biosyst. 2013 Nov; 9(11):2853-9. View Abstract

  39. A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity. 2013 Nov 14; 39(5):963-75. View Abstract

  40. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6. View Abstract

  41. A microbiota signature associated with experimental food allergy promotes allergic sensitization and anaphylaxis. J Allergy Clin Immunol. 2013 Jan; 131(1):201-12. View Abstract

  42. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol. 2013 Jul; 6(4):740-50. View Abstract

  43. IL-21 is the primary common ? chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 2011 Dec 22; 118(26):6824-35. View Abstract

  44. Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunol Rev. 2011 Jul; 242(1):128-43. View Abstract

  45. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J Allergy Clin Immunol. 2011 Jun; 127(6):1552-61.e1. View Abstract

  46. High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol. 2011 Jul 01; 187(1):164-71. View Abstract

  47. Mast cells and tumour necrosis factor alpha (TNF-a): partners in crime in asthma pathogenesis. Clin Immunol. 2011 Jul; 140(1):1-2. View Abstract

  48. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol. 2011 Mar; 127(3):795-805.e1-6. View Abstract

  49. Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls. J Allergy Clin Immunol. 2010 Dec; 126(6):1306-7.e2. View Abstract

  50. Anti-IgE in the treatment of allergic disorders in pediatrics. Curr Opin Pediatr. 2010 Dec; 22(6):758-64. View Abstract

  51. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. J Immunol. 2010 Jul 15; 185(2):1295-302. View Abstract

  52. In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif. J Allergy Clin Immunol. 2010 May; 125(5):1128-1136.e8. View Abstract

  53. Adaptive immunity. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S33-40. View Abstract

  54. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009 Oct; 124(4):761-70.e1. View Abstract

  55. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009 Sep 28; 206(10):2191-204. View Abstract

  56. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9. View Abstract

  57. Polyclonal IgE induces mast cell survival and cytokine production. Allergol Int. 2009 Sep; 58(3):411-9. View Abstract

  58. Lyn kinase controls basophil GATA-3 transcription factor expression and induction of Th2 cell differentiation. Immunity. 2009 Apr 17; 30(4):533-43. View Abstract

  59. Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. J Allergy Clin Immunol. 2009 Apr; 123(4):875-82.e1. View Abstract

  60. Novel presentation of Omenn syndrome in association with aniridia. J Allergy Clin Immunol. 2009 Apr; 123(4):966-9. View Abstract

  61. IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation. J Immunol. 2009 Feb 15; 182(4):2416-24. View Abstract

  62. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60. View Abstract

  63. Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten. Clin Exp Allergy. 2009 Mar; 39(3):417-25. View Abstract

  64. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. Cell Host Microbe. 2008 Oct 16; 4(4):362-73. View Abstract

  65. Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection. J Immunol. 2008 Apr 01; 180(7):4885-91. View Abstract

  66. TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation. J Immunol. 2008 Feb 01; 180(3):1878-85. View Abstract

  67. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8. View Abstract

  68. Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus. J Allergy Clin Immunol. 2007 Mar; 119(3):671-9. View Abstract

  69. The H1 histamine receptor regulates allergic lung responses. J Clin Invest. 2006 Jun; 116(6):1624-32. View Abstract

  70. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006 Jun; 117(6):1455-61. View Abstract

  71. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Int Immunol. 2006 Jan; 18(1):101-11. View Abstract

  72. COX-2 inhibition enhances the TH2 immune response to epicutaneous sensitization. J Allergy Clin Immunol. 2005 Aug; 116(2):390-6. View Abstract

  73. Antigen-independent effects of immunoglobulin E. Curr Allergy Asthma Rep. 2005 May; 5(3):186-90. View Abstract

  74. Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production. Cell Immunol. 2005 Jan; 233(1):11-22. View Abstract

  75. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells. Novartis Found Symp. 2005; 271:15-24; discussion 24-38, 95-9. View Abstract

  76. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004 Aug; 114(3):399-407. View Abstract

  77. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity. 2004 Apr; 20(4):381-92. View Abstract

  78. Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. Ann Allergy Asthma Immunol. 2004 Apr; 92(4):420-5. View Abstract

  79. IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol. 2004 Jan 15; 172(2):1139-45. View Abstract

  80. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003 Nov; 112(5):981-7. View Abstract

  81. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200. View Abstract

  82. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest. 2003 Oct; 112(7):1058-66. View Abstract

  83. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatr Allergy Immunol. 2003 Oct; 14(5):409-11. View Abstract

  84. Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J Allergy Clin Immunol. 2003 Jul; 112(1):149-58. View Abstract

  85. CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation. J Clin Invest. 2002 Mar; 109(5):621-8. View Abstract

  86. Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. Mayo Clin Proc. 2002 Jan; 77(1):92-6. View Abstract

  87. Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol. 2002 Jan; 109(1):106-13. View Abstract

  88. Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. Blood. 2001 Sep 01; 98(5):1321-5. View Abstract

  89. IgE regulation and roles in asthma pathogenesis. J Allergy Clin Immunol. 2001 Mar; 107(3):429-40. View Abstract

  90. Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis. J Immunol. 2001 Feb 01; 166(3):2033-40. View Abstract

  91. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2001 Feb; 107(2):359-66. View Abstract

  92. Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts. Curr Opin Immunol. 2000 Dec; 12(6):618-23. View Abstract

  93. CD40L, but not CD40, is required for allergen-induced bronchial hyperresponsiveness in mice. Am J Respir Cell Mol Biol. 2000 Nov; 23(5):646-51. View Abstract

  94. IgE in asthma and atopy: cellular and molecular connections. J Clin Invest. 1999 Oct; 104(7):829-35. View Abstract

  95. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43. View Abstract

  96. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999 Apr; 103(8):1103-11. View Abstract

  97. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3000-5. View Abstract

  98. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 01; 395(6701):462-9. View Abstract

  99. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J Exp Med. 1998 Sep 21; 188(6):1063-74. View Abstract

  100. The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE. Int Immunol. 1998 Sep; 10(9):1377-84. View Abstract

  101. A murine model of allergic rhinitis: studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin. J Allergy Clin Immunol. 1998 Jul; 102(1):65-74. View Abstract

  102. IgE regulates mouse basophil Fc epsilon RI expression in vivo. J Immunol. 1997 Mar 15; 158(6):2517-21. View Abstract

  103. Normal ranges for lymphocyte subsets in children. J Pediatr. 1997 Mar; 130(3):347-9. View Abstract

  104. Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. J Clin Immunol. 1997 Mar; 17(2):109-26. View Abstract

  105. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1344-9. View Abstract

  106. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med. 1997 Feb 17; 185(4):663-72. View Abstract

  107. Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni. J Immunol. 1997 Jan 01; 158(1):294-300. View Abstract

  108. Eotaxin triggers eosinophil-selective chemotaxis and calcium flux via a distinct receptor and induces pulmonary eosinophilia in the presence of interleukin 5 in mice. Mol Med. 1996 May; 2(3):334-48. View Abstract

  109. Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 04; 370(6488):367-70. View Abstract

  110. GD3 vaccines for melanoma: superior immunogenicity of keyhole limpet hemocyanin conjugate vaccines. Cancer Res. 1994 Jan 01; 54(1):197-203. View Abstract

  111. Cytokines in clinical cancer therapy. Curr Opin Immunol. 1991 Oct; 3(5):699-705. View Abstract

  112. Human monoclonal antibody with dual GM2/GD2 specificity derived from an immunized melanoma patient. Proc Natl Acad Sci U S A. 1990 May; 87(9):3333-7. View Abstract

  113. Requirements for activation of human peripheral blood T cells by mouse monoclonal antibodies to CD3. Clin Immunol Immunopathol. 1987 Apr; 43(1):48-64. View Abstract

  114. The T-cell receptor-T3 complex and T-lymphocyte activation. Hum Immunol. 1987 Mar; 18(3):187-204. View Abstract

  115. A review of the structure and function of the T-cell receptor-T3 complex. Crit Rev Immunol. 1987; 7(2):131-67. View Abstract

  116. Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell. 1986 Nov 07; 47(3):365-70. View Abstract

  117. A T3-like protein complex associated with the antigen receptor on murine T cells. Nature. 1986 Mar 20-26; 320(6059):272-5. View Abstract

  118. The T cell receptor/T3 complex. Year Immunol. 1986; 2:245-53. View Abstract

  119. Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: specificity analysis and comparison of antigen expression in cultured cells and tissues. Cancer Res. 1985 Sep; 45(9):4401-11. View Abstract

  120. Purification, preliminary characterization, and immunological comparison of hog lens leucine aminopeptidase (EC 3.4.11.1) with hog kidney and beef lens aminopeptidases. Anal Biochem. 1985 Apr; 146(1):238-45. View Abstract

  121. Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell. 1985 Mar; 40(3):583-90. View Abstract

  122. The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits. EMBO J. 1985 Feb; 4(2):337-44. View Abstract

  123. The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides. Nature. 1984 Nov 29-Dec 5; 312(5993):455-8. View Abstract

  124. Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. J Biol Chem. 1984 Oct 10; 259(19):12039-48. View Abstract

  125. Comparison of leucine aminopeptidase from human lens, beef lens and kidney, and hog lens and kidney. Exp Eye Res. 1984 Mar; 38(3):217-29. View Abstract

  126. In vivo localization of cloned IL-2-dependent T cells. Cell Immunol. 1983 Feb 15; 76(1):69-80. View Abstract

  127. Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983; 2(1):17-28. View Abstract
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