Important studies in this area
**Bolded studies indicate studies performed by our team
Studies about ECPR outcomes
Sperotto F, Saengsin K, Danehy A, Godsay M, Geisser DL, Rivkin M, Amigoni A, Thiagarajan RR, Kheir JN. Modeling severe functional impairment or death following ECPR in pediatric cardiac patients: Planning for an interventional trial. Resuscitation. 2021 Oct;167:12-21. Doi: 10.1016/j.resuscitation.2021.07.041. Epub 2021 Aug 10. PMID: 34389452.
Bembea MM, Ng DK, Rizkalla N, Rycus P, Lasa JJ, Dalton H, Topjian AA, Thiagarajan RR, Nadkarni VM, Hunt EA; American Heart Association’s Get With The Guidelines – Resuscitation Investigators. Outcomes After Extracorporeal Cardiopulmonary Resuscitation of Pediatric In-Hospital Cardiac Arrest: A Report From the Get With the Guidelines-Resuscitation and the Extracorporeal Life Support Organization Registries. Crit Care Med. 2019 Apr;47(4):e278-e285. Doi: 10.1097/CCM.0000000000003622. PMID: 30747771.
Studies about hydrogen’s effectiveness and safety
Cole AR, Perry DA, Raza A, Nedder AP, Pollack E, Regan WL, van den Bosch SJ, Polizzotti BD, Yang E, Davila D, Afacan O, Warfield SK, Ou Y, Sefton B, Everett AD, Neil JJ, Lidov HGW, Mayer JE, Kheir JN. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci. 2019 Mar 27;4(2):176-187. doi: 10.1016/j.jacbts.2018.11.006. PMID: 31061920; PMCID: PMC6488769.
Cole AR, Raza A, Ahmed H, Polizzotti BD, Padera RF, Andrews N, Kheir JN. Safety of inhaled hydrogen gas in healthy mice. Med Gas Res. 2019 Jul-Sep;9(3):133-138. doi: 10.4103/2045-9912.266988. PMID: 31552876; PMCID: PMC6779003.
Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 2007 Jun;13(6):688-94. doi: 10.1038/nm1577. Epub 2007 May 7. PMID: 17486089.
Yin T, Becker LB, Choudhary RC, Takegawa R, Shoaib M, Shinozaki K, Endo Y, Homma K, Rolston DM, Eguchi S, Ariyoshi T, Matsumoto A, Oka K, Takahashi M, Aoki T, Miyara SJ, Nishikimi M, Sasaki J, Kim J, Molmenti EP, Hayashida K. Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats. J Transl Med. 2021 Nov 16;19(1):462. doi: 10.1186/s12967-021-03129-1. PMID: 34781966; PMCID: PMC8594155.
Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S. Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management. Circulation. 2014 Dec 9;130(24):2173-80. doi: 10.1161/CIRCULATIONAHA.114.011848. Epub 2014 Nov 3. PMID: 25366995.
Gong X, Fan X, Yin X, Xu T, Li J, Guo J, Zhao X, Wei S, Yuan Q, Wang J, Han X, Chen Y. Hydrogen therapy after resuscitation improves myocardial injury involving inhibition of autophagy in an asphyxial rat model of cardiac arrest. Exp Ther Med. 2022 Jun;23(6):376. doi: 10.3892/etm.2022.11302. Epub 2022 Apr 7. PMID: 35495584; PMCID: PMC9019777.
Studies about hydrogen use in humans
Cole AR, Sperotto F, DiNardo JA, Carlisle S, Rivkin MJ, Sleeper LA, Kheir JN. Safety of Prolonged Inhalation of Hydrogen Gas in Air in Healthy Adults. Crit Care Explor. 2021 Oct 8;3(10):e543. Doi: 10.1097/CCE.0000000000000543. PMID: 34651133; PMCID: PMC85
Ono H, Nishijima Y, Ohta S, Sakamoto M, Kinone K, Horikosi T, Tamaki M, Takeshita H, Futatuki T, Ohishi W, Ishiguro T, Okamoto S, Ishii S, Takanami H. Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection. J Stroke Cerebrovasc Dis. 2017 Nov;26(11):2587-2594. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.012. Epub 2017 Jun 29. PMID: 28669654.
Tamura T, Hayashida K, Sano M, Onuki S, Suzuki M. Efficacy of inhaled HYdrogen on neurological outcome following BRain Ischemia During post-cardiac arrest care (HYBRID II trial): study protocol for a randomized controlled trial. Trials. 2017 Oct 23;18(1):