Researcher | Research Overview
The Manis lab focuses on the development of the immune system. One area of work focuses on the basic mechanisms that control programmed DNA breaks in B cells of the immune system. Errors in the repair of programmed immune system breaks lead to immunodeficiency and can lead to cancers including lymphoma. The laboratory has expertise in generating gene-targeted mouse embryonic stem cells and mice to study immune system defects. Another area of focus is in developing mouse models for human primary immunodeficiency syndromes. Presently, a mouse model of Job's Syndrome, replicating autosomal-dominant Hyper IgE syndrome due to defective Stat 3 is being examined to understand lineage specific contributions to the disease.