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Research Overview

Nate’s research is focused on the role of oxidative stress and redox buffering in neurological disorders. Currently he is studying the regulation of perineuronal net formation by Otx2 and how perineuronal nets regulate redox homeostasis. He is interested in the role redox plays in disease and plasticity, specifically in regards to the highly metabolically active fast-spiking parvalbumin-expressing interneuron. Nate is an expert in rodent behavior, HPLC, redox metabolism, stereotaxic surgery, microdialysis/microperfusion and biochemistry.

Research Background

Nate received his BS from Gettysburg College in 2006 and PhD from Northeastern University in 2012. Since receiving his PhD Nate has worked for Pfizer in the Neuroscience and Pain department in the Psychiatry group, and as a post-doc in the labs of Takao Hensch at Harvard University and Boston Children's Hospital. Nate has been a senior member of the Integrated Behavior and Physiology Core since 2019.

Selected Publications

  1. McNair, L., Andersen, J., Aldana, B., Hohnholt, M., Nissen, J., Sun, Y., Fischer, K., Sonnewald, U., Nyberg, N., Webster, S., Kapur, K., Rimmele, T., Barone, I., Hawks-Mayer, H., Lipton, J., Hodgson, N., Aoki, C., Rosenberg, P., Waagepetersen, H. (2019) Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function. Journal of Neuroscience.
  2. Zhang, Y., Hodgson, N., Trivedi, M., Deth, R. (2016) Neuregulin 1 promotes glutathione-dependent neuronal cobalamin metabolism by stimulation cysteine uptake. Oxidative Medicine and Cellular Longevity.
  3. Zhang, Y., Hodgson, N., Trivedi, M., Abdolmaleky, H., Fournier, M., Cuenod, M., Do, K., Deth, R. (2016) Decreased brain levels of vitamin B12 in aging, autism and schizophrenia. PLoS One.
  4. Trivedi, M., Hodgson, N., Walker, S., Trooskens, G., Nair, V., Deth, R. (2015) Epigenetic effects of casein-derived opioid peptides in SH-SY5Y human neuroblastoma cells. Nutrition and Metabolism. Trivedi, M., Shah, J., Al-Mughairy, S., Hodgson, N., Simms, B., Trooskens, G., Van Criekinge, W., Deth, R. (2014) Food-derived opioid peptides inhibit cysteine uptake with redox and epigenetic consequences. Journal of Nutritional Biochemistry.
  5. Hodgson, N., Waly, M., Al-Farsi, Y., Deth, R. (2014) Decreased glutathione and elevated hair mercury levels are associated with nutritional deficiency-based autism in Oman. Experimental Biology and Medicine.
  6. Trivedi, M., Shah, J., Hodgson, N., Byun, H., Deth, R. (2014) Morphine induces redox-based changes in global DNA methylation and retrotransposon transcription by inhibition of excitatory amino Acid transporter type 3-mediated cysteine uptake. Molecular Pharmacology.
  7. Hodgson, N., Trivedi, M., Muratore, C., Li, S., Deth, R. (2013) Soluble oligomers of amyloid ß cause oxidative stress, alter thiol metabolism and change methylation state by disrupting EAAT3-mediated cysteine uptake. Journal of Alzheimer’s Disease. 36: 197-209.
  8. Muratore, C.R., Hodgson, N., Trivedi, M., Abdolmaleky, H.M., Persico, A.M., De La Monte, S., Deth, R.C. (2013) Age-dependent decrease and alternative splicing of methionine synthase mRNA in human cortex: Accelerated decrease in autism. PloS ONE. 8.
  9. Zhou, Y.N., Coleman, W.G. Jr., Yang, Z., Yang, Y., Hodgson, N., Chen, F., Jin, D.J. (2008) Regulation of cell growth during serum starvation and bacterial survival in macrophages by the bifunctional enzyme SpoT in Helicobacter pylori. Journal of Bacteriology. 24: 8025-32.