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Research Overview

Xinjun received his PhD in Biology from Tsinghua University in 2006. He joined the lab in May 2006 and is currently studying the mechanism of a novel Wnt inhibitor.

Selected Publications

  1. Ye X, Zhang Z, Zhang X, Lin G, Xiong S, Jin G, Han L, Huang S, Chen P, Ai J, Xin D, Guo Y, Chang Z. Functional Interaction of TCF4 with ATF5 to Regulate the Wnt signaling pathway. Chinese Science Bulletin. 2003, 48(7): 668-673.
  2. Tamai K*, Zeng X*, Liu C, Zhang X, Harada Y, Chang Z, He X. A mechanism for Wnt coreceptor activation. Mol Cell. 2004, 13(1): 149-56 (“*” co-first author)
  3. Han L, Zhang X, NG S-S, Zhai Y, Chang Z. MAAT1 p15 Interacts with LRP6 and Regulates Wnt Signaling Pathway. Chinese Journal of Biochemistry and Molecular Biology. 2004, 20(6): 827-832
  4. NG S-S, Zhai Y, Han L, Zhang X, Chang Z. Screening of Proteins Interacting with Dishevelled2 in Mouse 11.5dpc Embryo Library. Chinese Journal of Biotechnology. 2004, 20(5): 750-753
  5. Li L*, Xin H*, Xu X, Huang M, Zhang X, Chen Y, Zhang S, Fu X-Y, Chang Z. CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Mol Cell Biol. 2004, 24(2):856-64 (“*” co-first author)
  6. Zhang X, He X, Fu X-Y, Chang Z. Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J Cell Sci. 2006, 119, 1053-1062
  7. Ren Y, Cheng L, Rong Z, Li Z, Li Y, Zhang X, Xiong S, Hu J, Fu XY, Chang Z. hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation. Cell Signal. 2008 Mar;20(3):518-33.
  8. Zeng X*, Huang H*, Tamai K, Zhang X, Harada, Y, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh J-C, He X. Initiation of Wnt signaling: Control of Wnt coreceptor LRP6 phosphorylation/activation via Frizzled/Dishevelled/Axin Functions. Development.  2008, 135(2):367-75. (“*” co-first author)
  9. Wang F, Zhang H, Zhang X, Wang Y, Ren F, Zhang X, Zhai Y, Chang Z. Varp interacts with Rab38 and functions as its potential effector. Biochem Biophys Res Commun. 2008 Jul 18;372(1):162-7.
  10. Semënov MV, Zhang X, He X. DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation. J Biol Chem. 2008 Aug 1;283(31):21427-32.