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2015

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  • Diabetes primes neutrophils to undergo NETosis which severely impairs wound healing.
    Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, Kahn CR, Wagner DD.                                                                                            Nat Med. 2015 Jun 15. doi: 10.1038/nm.3887. [Epub ahead of print]
    • ADAMTS13 protects against thrombotic microangiopathy in mice receiving VEGF inhibitor
      Erpenbeck L, Demers M, Zsengeller Z, Gallant M, Cifuni S, Stillman IE, Karumanchi SA, Wagner DD; ,                                                                          2015, Jun 2. pii: JASN.2014121165. [Epub ahead of print]
      • Tissue factor expressed by circulating cancer cell-derived microparticles drastically increases the incidence of deep vein thrombosis in mice
        Thomas GM, Brill A, Mezouar L, Crescence L, Gallant M, Dubois C, Wagner DD.                                                                                                               JTH 2015 Jul;13(7):1310-9. doi: 10.1111/jth.13002. Epub 2015 Jun 8.
        • P-selectin promotes neutrophil extracellular trap formation in mice.                                                                                                          Etulain J, Martinod K, Wong SL, Cifuni SM, Schattner M, Wagner DD.                                                                                                                     Blood. 2015 Jul 9;126(2):242-6. doi: 10.1182/blood-2015-01-624023. Epub 2015 May 15.
          • PAD4-deficiency does not affect bacteremia in polymicrobial sepsis and ameliorates endotoxemic shock.                                            Martinod K, Fuchs Ta, Zitomersky NL, Wong SL, Demers M, Gallant M Wang Y, Wagner DD.                                                                                     Blood. 2015 Mar 19;125(12):1948-56 233.
            • Inhibition of PAD4 enzymatic activity is sufficient for disruption of mouse and human NET formation.                                                                                                                                                                                                       Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung C, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, Rüdiger M, Sheppard RJ, Slade DJ,  Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, David M. Wilson DM.                                                                                                                                Nat Chem Biol. 2015 Mar;11(3):189-91 PMCID:4397581
                • Dietary Omega-3 Alpha-Linolenic Acid does not prevent venous thrombosis in mice.                                                                                                                                                                                                               Reiner MF, Martinod K, Stivala S, Camici GC, Luscher TF, Wagner DD, Beer JH.                                                                                                               Thromb Haemost. 2015 Jan;113(1):177-84. PMC in Process

                  2014

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                  • VWF-mediated leukocyte recruitment with chromatin decondensation by PAD4 increases myocardial ischemia/reperfusion injury in mice.

                    Savchenko AS, Borissoff JI, Martinod K, De Meyer SF, Gallant M, Erpenbeck L, Brill A, Wang Y, Wagner DD.

                    Blood, Volume: 123, Pages: 141-148 (2014) [PubMed]

                  • Thrombosis: Tangled up in NETs.

                    Martinod K, Wagner DD

                    Blood, Volume: 123, Pages: 2768-2776 (2014)

                  • NETosis: a new factor in tumor progression and cancer-associated thrombosis.

                    Demers M, Wagner DD

                    Semin Thromb Hemost, Volume: 40, Pages: 277-283 (2014)

                  • Neutrophil extracellular traps form predominantly during the organizing stage of human venous thromboembolism development

                    Savchenko AS, Martinod K, Seidman MA, Wong SL, Borissoff JI, Piazza G, Libby P, Goldhaber SZ, Mitchell RN, Wagner DD

                    J Thromb Haemost, Volume: 12, Pages: 860-70 (2014) [PubMed]

                  • Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

                    Chen G, Zhang D, Fuchs TA, Manwani D, Wagner DD, Frenette PS

                    Blood, Volume: 123, Pages: 3818-27 (2014) [PubMed]

                  2013

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                  • Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice.

                    Duerschmied D, Suidan GL, Demers M, Herr N, Carbo C, Brill A, Cifuni SM, Mauler M, Cicko S, Bader M, Idzko M, Bode C, Wagner DD.

                    Blood, Volume: 121, Pages: 1008-15 (2013) [PubMed]

                  • Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model.

                    Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M.

                    J Anesth, Volume: 27, Pages: 261-268 (2013) [PubMed]

                  • Lack of tryptophan hydroxylase-1 in mice results in gait abnormalities.

                    Suidan GL, Duerschmied D, Dillon GM, Vanderhorst V, Hampton TG, Wong SL, Voorhees JR, Wagner DD.

                    PLoS One, Volume: 8, Pages: e59032 (2013) [PubMed]

                  • Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression.

                    Demers M, Wagner DD.

                    Oncoimmunology, Volume: 2, Pages: e22946 (2013) [PubMed]

                  • Plasma DNA is elevated in patients with deep vein thrombosis.

                    Diaz JA, Fuchs TA, Jackson TO, Hovinga JA, Lämmle B, Henke PK, Myers DD Jr, Wagner DD, Wakefield TW; for the Michigan Research Venous Group

                    J Vasc Surg, Volume: 1, Pages: doi: 10.1016/j.jvsv.2012.12.002. (2013) [PubMed]

                  • Neutrophils release extracellular DNA traps during storage of red blood cell units.

                    Fuchs TA, Alvarez JJ, Martinod K, Bhandari AA, Kaufman RM, Wagner DD.

                    Transfusion, Volume: 53, Pages: 3210-6 (2013) [PubMed]

                  • Hypoxia, such as encountered at high altitude, promotes deep vein thrombosis in mice.

                    Brill A, Suidan GL, Wagner DD.

                    J Thromb Haemost, Volume: 11, Pages: 1773-5 (2013)

                  • Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice.

                    Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, Hu J, Wang Y, Wagner DD.

                    Proc Natl Acad Sci U S A, Volume: 110, Pages: 8674-9 (2013) [PubMed]

                  • Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.

                    Borissoff JI, Joosen IA, Versteylen MO, Brill A, Fuchs TA, Savchenko AS, Gallant M, Martinod K, Ten Cate H, Hofstra L, Crijns HJ, Wagner DD, Kietselaer BL.

                    Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2032-2040 (2013) [PubMed]

                  • Endothelial von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.

                    Suidan GL, Brill A, De Meyer SF, Voorhees JR, Cifuni SM, Cabral JE, Wagner DD.

                    Arterioscler Thromb Vasc Biol, Volume: 33, Pages: 2112-20 (2013) [PubMed]

                  2012

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                  • Targeting platelet function to improve drug delivery.

                    Demers M, Wagner DD.

                    OncoImmunology, Volume: 1, Pages: 100-02 (2012) [PubMed]

                  • von Willebrand factor: an emerging target in stroke therapy.

                    De Meyer SF, Stoll G, Wagner DD, Kleinschnitz C.

                    Stroke, Volume: 43, Pages: 599-606 (2012) [PubMed]

                  • Desialylation accelerates platelet clearance following refrigeration and initiates GPIbα metalloproteinase-mediated cleavage in mice.

                    Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM

                    Blood, Volume: 119, Pages: 1263-73 (2012) [PubMed]

                  • Neutrophil extracellular traps promote deep vein thrombosis in mice.

                    Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD.

                    J Thromb Haemost, Volume: 10, Pages: 136-44 (2012) [PubMed]

                  • ARC15105 is a potent antagonist of von Willebrand factor mediated platelet activation and adhesion.

                    Siller-Matula JM, Merhi Y, Tanguay JF, Duerschmied D, Wagner DD, McGinness KE, Pendergrast PS, Chung JK, Tian X, Schaub RG, Jilma B.

                    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 902-9 (2012) [PubMed]

                  • Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo.

                    von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S.

                    J Exp Med, Volume: 209, Pages: 819-35 (2012) [PubMed]

                  • Circulating DNA and myeloperoxidase indicate disease activity in patients with thrombotic microangiopathies.

                    Fuchs TA, Kremer Hovinga JA, Schatzberg D, Wagner DD, Lämmle B.

                    Blood, Volume: 120, Pages: 1157-64 (2012) [PubMed]

                  • Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice.

                    Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD.

                    Blood, Volume: 119, Pages: 6335-43 (2012) [PubMed]

                  • Extracellular chromatin is an important mediator of ischemic stroke in mice.

                    De Meyer SF, Suidan GL, Fuchs TA, Monestier M, Wagner DD.

                    , Volume: 32, Pages: 1884-91 (2012) [PubMed]

                  • Neutrophil extracellular trap (NET) impact on deep vein thrombosis.

                    Fuchs TA, Brill A, Wagner DD.

                    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1777-83 (2012) [PubMed]

                  • Extrahepatic high-density lipoprotein receptor SR-BI and apoA-I protect against deep vein thrombosis in mice.

                    Brill A, Yesilaltay A, De Meyer SF, Kisucka J, Fuchs TA, Kocher O, Krieger M, Wagner DD.

                    Arterioscler Thromb Vasc Biol, Volume: 32, Pages: 1841-7 (2012) [PubMed]

                  • Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.

                    Korin N, Kanapathipillai M, Matthews BD, Crescente M, Brill A, Mammoto T, Ghosh K, Jurek S, Bencherif SA, Bhatta D, Coskun AU, Feldman CL, Wagner DD, Ingber DE.

                    Science, Volume: 337, Pages: 738-42 (2012) [PubMed]

                  • Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.

                    Demers M, Krause DS, Schatzberg D, Martinod K, Voorhees JR, Fuchs TA, Scadden DT, Wagner DD.

                    Proc Natl Acad Sci U S A, Volume: 106, Pages: 13076-81 (2012) [PubMed]

                  • ADAMTS13 exerts a thrombolytic effect in microcirculation.

                    Crescente M, Thomas GM, Demers M, Voorhees JR, Wong SL, Ho-Tin-Noé B, Wagner DD.

                    Thromb Haemost, Volume: 108, Pages: 527-32 (2012) [PubMed]

                  • Protective anti-inflammatory effect of ADAMTS13 on myocardial ischemia/reperfusion injury in mice.

                    De Meyer SF, Savchenko AS, Haas MS, Schatzberg D, Carroll MC, Schiviz A, Dietrich B, Rottensteiner H, Scheiflinger F, Wagner DD.

                    Blood 2012 Dec 20;120(26):5217-23. , Volume: 120, Pages: 5217-23 (2012) [PubMed]

                  • Endocytosis of soluble immune complexes leads to their clearance by FcγRIIIB but induces neutrophil extracellular traps via FcγRIIA in vivo.

                    Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN.

                    Blood , Volume: 120, Pages: 4421-31 (2012) [PubMed]

                  2011

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                  • Increased efficacy of breast cancer chemotherapy in thrombocytopenic mice.

                    Demers M, Ho-Tin-Noé B, Schatzberg D, Yang JJ, Wagner DD

                    Cancer Res, Volume: 71 , Pages: 1540-9 (2011) [PubMed]

                  • von Willebrand factor-mediated platelet adhesion is critical for deep vein thrombosis in mouse models.

                    Brill A, Fuchs TA, Chauhan AK, Yang JJ, De Meyer SF, Köllnberger M, Wakefield TW, Lämmle B, Massberg S, Wagner DD.

                    Blood., Volume: 117, Pages: 1400-7 (2011) [PubMed]

                  • The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

                    Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD and Degen JL

                    Blood., Volume: 117, Pages: 6326-6337 (2011) [PubMed]

                  • Rap1a activation by CalDAG-GEFI and p38 MAPK is involved in E-selectin-dependent slow leukocyte rolling.

                    Stadtmann A, Brinkhaus L, Mueller H, Rossaint J, Bolomini-Vittori M, Bergmeier W, Van Aken H, Wagner DD, Laudanna C, Ley K, Zarbock A.

                    Eur J Immunol, Volume: 41, Pages: 2074-2085 (2011) [PubMed]

                  • Histones induce rapid and profound thrombocytopenia in mice.

                    Fuchs TA, Bhandari AA, Wagner DD.

                    Blood, Volume: 118, Pages: 3708-3714 (2011) [PubMed]

                  • How platelets safeguard vascular integrity.

                    Ho-Tin-Noé B, Demers M, Wagner DD.

                    J Thromb Haemost, Volume: 9 , Pages: 56-65 (2011) [PubMed]

                  • Platelet glycoprotein Ibalpha is an important mediator of ischemic stroke in mice.

                    De Meyer SF, Scwharz T, Schatzberg D, Wagner DD.

                    Exp Transl Stroke Med, Volume: 3, Pages: 9 (2011) [PubMed]

                  2010

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                  • p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo.

                    Canault M, Duerschmied D, Brill A, Stefanini L. Schatzberg D, Cifuni SM, Bergmeier, Wagner DD

                    Blood, Volume: 115, Pages: 1835-42 (2010) [PubMed]

                  • Integrin-independent role of CalDAG-GEFI in neutrophil chemotaxis.

                    Carbo C, Duerschmied D, Goerge T, Hattori H, Sakai J, Cifuni SM, White II GC, Chrzanowska-Wodnicka M, Luo HR, Wagner DD

                    J Leukoc Biol, , Volume: 88, Pages: 313-19 (2010) [PubMed]

                  • The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation.

                    Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO.

                    PLoS One. , Volume: 5, Pages: e13433 (2010) [PubMed]

                  • A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.

                    Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH.

                    J Exp Med, Volume: 207, Pages: 1967-79 (2010) [PubMed]

                  • Extracellular DNA traps promote thrombosis.

                    Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD Jr, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD.

                    Proc Natl Acad Sci U S A. , Volume: 107, Pages: 15880-5 (2010) [PubMed]

                  2009

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                  • The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation.

                    Banno F, Chauhan AK, Kokame K, Yang J, Miyata S, Wagner DD, and Miyata T.

                    Blood, Volume: 113, Pages: 5323-5329 (2009) [PubMed]

                  • Differential stimulation of monocytic cells results in distinct populations of microparticles.

                    Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD.

                    J Thromb Haemost, Volume: 7, Pages: 1019-1028 (2009) [PubMed]

                  • Structure, biology and genetics of von Willebrand factor.

                    Ginsburg D and Wagner DD. Structure, biology and genetics of von Willebrand factor.

                    In: Hematology: Basic Principles and Practices. 5th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Silberstein LE, McGlave P, Heslop H. (Eds.). NY: Churchill Livingstone (2009)

                  • Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis.

                    Kisucka J, Chauhan AK, Zhao BQ, Patten IS, Yesilaltay A, Krieger M, Wagner DD.

                    Blood, Volume: 113, Pages: 6015-6022 (2009) [PubMed]

                  • Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779.

                    Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R.

                    J Thromb Haemost, Volume: 7, Pages: 1155-1162 (2009) [PubMed]

                  • Serotonin stimulates platelet receptor shedding by tumor necrosis factor-alpha-converting enzyme (ADAM17).

                    Duerschmied D, Canault M, Lievens D, Brill A, Cifuni SM, Bader M, Wagner DD.

                    J Thromb Haemost, Volume: 7, Pages: 1163-1171 (2009) [PubMed]

                  • Platelets: guardians of tumor vasculature.

                    Ho-Tin-Noe B, Goerge T, Wagner DD.

                    Cancer Res, Volume: 69, Pages: 5623-5626 (2009) [PubMed]

                  • Inhibition of VEGF or TGF-{beta} signaling activates endothelium and increases leukocyte rolling.

                    Walshe TE, Dole VS, Maharaj AS, Patten IS, Wagner DD, D'Amore PA.

                    Arterioscler Thromb Vasc Biol, Volume: 29, Pages: 1185-1192 (2009) [PubMed]

                  • Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion.

                    Brill A, Chauhan AK, Canault M, Walsh MT, Bergmeier W, Wagner DD.

                    Cardiovasc Res, Volume: 84, Pages: 137-144 (2009) [PubMed]

                  • Innate immune cells induce hemorrhage in tumors during thrombocytopenia.

                    Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD.

                    Am J Path, Volume: 175, Pages: 1699-708 (2009) [PubMed]

                  • von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke.

                    Zhao BQ, Chauhan AK, Canault M, Patten IS, Yang JJ, Dockal M, Scheiflinger F, Wagner DD.

                    Blood, Volume: 114, Pages: 3329-34 (2009) [PubMed]

                  2008

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                  • CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets

                    Cifuni, S. M.; Wagner, D. D.; Bergmeier, W.

                    Blood, Volume: 112, Pages: 1696-703 (2008) [PubMed]

                  • The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis

                    Chauhan, A. K.; Walsh, M. T.; Zhu, G.; Ginsburg, D.; Wagner, D. D.; Motto, D. G.

                    Blood, Volume: 111, Pages: 3452-7 (2008) [PubMed]

                  • Prothrombotic effects of fibronectin isoforms containing the EDA domain

                    Chauhan, A. K.; Kisucka, J.; Cozzi, M. R.; Walsh, M. T.; Moretti, F. A.; Battiston, M.; Mazzucato, M.; De Marco, L.; Baralle, F. E.; Wagner, D. D.; Muro, A. F.

                    Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 296-301 (2008) [PubMed]

                  • The effect of C1 inhibitor on intestinal ischemia and reperfusion injury

                    Lu, F.; Chauhan, A. K.; Fernandes, S. M.; Walsh, M. T.; Wagner, D. D.; Davis 3rd, A. E.

                    Am J Physiol Gastrointest Liver Physiol (2008) [PubMed]

                  • Peroxiredoxin1 prevents excessive endothelial activation and early atherosclerosis

                    Kisucka, J.; Chauhan, A. K.; Patten, I. S.; Yesilaltay, A.; Neumann, C.; Van Etten, R. A.; Krieger, M.; Wagner, D. D.

                    Circ Res, Volume: 103, Pages: 598-605 (2008) [PubMed]

                  • Platelet granule secretion continuously prevents intratumor hemorrhage

                    Ho-Tin-Noe, B.; Goerge, T.; Cifuni, S. M.; Duerschmied, D.; Wagner, D. D.

                    Cancer Res, Volume: 68, Pages: 6851-8 (2008) [PubMed]

                  • Thrombocytopenia and platelet abnormalities in high-density lipoprotein receptor-deficient mice

                    Dole, V. S.; Matuskova, J.; Vasile, E.; Yesilaltay, A.; Bergmeier, W.; Bernimoulin, M.; Wagner, D. D.; Krieger, M.

                    Arterioscler Thromb Vasc Biol, Volume: 28, Pages: 1111-6 (2008) [PubMed]

                  • Glycoprotein Ibalpha and von Willebrand factor in primary platelet adhesion and thrombus formation: lessons from mutant mice

                    Bergmeier, W.; Chauhan, A. K.; Wagner, D. D.

                    Thromb Haemost, Volume: 99, Pages: 264-70 (2008) [PubMed]

                  • The vessel wall and its interactions

                    Wagner, D. D.; Frenette, P. S.

                    Blood, Volume: 111, Pages: 5271-81 (2008) [PubMed]

                  • Inflammation induces hemorrhage in thrombocytopenia

                    Goerge, T.; Ho-Tin-Noe, B.; Carbo, C.; Benarafa, C.; Remold-O'Donnell, E.; Zhao, B. Q.; Cifuni, S. M.; Wagner, D. D.

                    Blood, Volume: 111, Pages: 4958-64 (2008) [PubMed]

                  • von-Willebrand factor influences blood brain barrier permeability and brain inflammation in experimental allergic encephalomyelitis

                    Noubade, R.; del Rio, R.; McElvany, B.; Zachary, J. F.; Millward, J. M.; Wagner, D. D.; Offner, H.; Blankenhorn, E. P.; Teuscher, C.

                    Am J Pathol, Volume: 173, Pages: 892-900 (2008) [PubMed]

                  • ADAMTS13: a new link between thrombosis and inflammation

                    Chauhan, A. K.; Kisucka, J.; Brill, A.; Walsh, M. T.; Scheiflinger, F.; Wagner, D. D.

                    J Exp Med, Volume: 205, Pages: 2065-74 (2008) [PubMed]

                  2007

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                  • Formation of platelet strings and microthrombi in the presence of ADAMTS-13 inhibitor does not require P-selectin or beta3 integrin

                    Chauhan, A. K.; Goerge, T.; Schneider, S. W.; Wagner, D. D.

                    J Thromb Haemost, Volume: 5, Pages: 583-9 (2007) [PubMed]

                  • Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

                    Zhu, L.; Bergmeier, W.; Wu, J.; Jiang, H.; Stalker, T. J.; Cieslak, M.; Fan, R.; Boumsell, L.; Kumanogoh, A.; Kikutani, H.; Tamagnone, L.; Wagner, D. D.; Milla, M. E.; Brass, L. F.

                    Proc Natl Acad Sci U S A, Volume: 104, Pages: 1621-6 (2007) [PubMed]

                  • ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage

                    Hafezi-Moghadam, A.; Thomas, K. L.; Wagner, D. D.

                    Am J Physiol Cell Physiol, Volume: 292, Pages: C1256-62 (2007) [PubMed]

                  • Alteromonas tagae sp. nov. and Alteromonas simiduii sp. nov., mercury-resistant bacteria isolated from a Taiwanese estuary

                    Chiu, H. H.; Shieh, W. Y.; Lin, S. Y.; Tseng, C. M.; Chiang, P. W.; Wagner-Dobler, I.

                    Int J Syst Evol Microbiol, Volume: 57, Pages: 1209-16 (2007) [PubMed]

                  • von Willebrand factor and factor VIII are independently required to form stable occlusive thrombi in injured veins

                    Chauhan, A. K.; Kisucka, J.; Lamb, C. B.; Bergmeier, W.; Wagner, D. D.

                    Blood, Volume: 109, Pages: 2424-9 (2007) [PubMed]

                  • PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets

                    Dole, V. S.; Bergmeier, W.; Patten, I. S.; Hirahashi, J.; Mayadas, T. N.; Wagner, D. D.

                    Thromb Haemost, Volume: 98, Pages: 806-12 (2007) [PubMed]

                  • Platelet adhesion receptors and their ligands in mouse models of thrombosis

                    Denis, C. V.; Wagner, D. D.

                    Arterioscler Thromb Vasc Biol, Volume: 27, Pages: 728-39 (2007) [PubMed]

                  • Dynamic visualization of thrombopoiesis within bone marrow

                    Junt, T.; Schulze, H.; Chen, Z.; Massberg, S.; Goerge, T.; Krueger, A.; Wagner, D. D.; Graf, T.; Italiano, J. E., Jr.; Shivdasani, R. A.; von Andrian, U. H.

                    Science, Volume: 317, Pages: 1767-70 (2007) [PubMed]

                  • Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III

                    Bergmeier, W.; Goerge, T.; Wang, H. W.; Crittenden, J. R.; Baldwin, A. C.; Cifuni, S. M.; Housman, D. E.; Graybiel, A. M.; Wagner, D. D.

                    J Clin Invest, Volume: 117, Pages: 1699-707 (2007) [PubMed]

                  • In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration

                    Babic, A. M.; Josefsson, E. C.; Bergmeier, W.; Wagner, D. D.; Kaufman, R. M.; Silberstein, L. E.; Stossel, T. P.; Hartwig, J. H.; Hoffmeister, K. M.

                    Transfusion, Volume: 47, Pages: 442-51 (2007) [PubMed]

                  • Platelet adhesion receptors do not modulate infarct volume after a photochemically induced stroke in mice

                    Frederix, K.; Chauhan, A. K.; Kisucka, J.; Zhao, B. Q.; Hoff, E. I.; Spronk, H. M.; Ten Cate, H.; Wagner, D. D.

                    Brain Res, Volume: 1185, Pages: 239-45 (2007) [PubMed]

                  2006

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                  • Systemic antithrombotic effects of ADAMTS13

                    Chauhan, A. K.; Motto, D. G.; Lamb, C. B.; Bergmeier, W.; Dockal, M.; Plaimauer, B.; Scheiflinger, F.; Ginsburg, D.; Wagner, D. D.

                    J Exp Med, Volume: 203, Pages: 767-76 (2006) [PubMed]

                  • Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy

                    Hirahashi, J.; Mekala, D.; Van Ziffle, J.; Xiao, L.; Saffaripour, S.; Wagner, D. D.; Shapiro, S. D.; Lowell, C.; Mayadas, T. N.

                    Immunity, Volume: 25, Pages: 271-83 (2006) [PubMed]

                  • Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage

                    Kisucka, J.; Butterfield, C. E.; Duda, D. G.; Eichenberger, S. C.; Saffaripour, S.; Ware, J.; Ruggeri, Z. M.; Jain, R. K.; Folkman, J.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 103, Pages: 855-60 (2006) [PubMed]

                  • The A2B adenosine receptor protects against inflammation and excessive vascular adhesion

                    Yang, D.; Zhang, Y.; Nguyen, H. G.; Koupenova, M.; Chauhan, A. K.; Makitalo, M.; Jones, M. R.; St Hilaire, C.; Seldin, D. C.; Toselli, P.; Lamperti, E.; Schreiber, B. M.; Gavras, H.; Wagner, D. D.; Ravid, K.

                    J Clin Invest, Volume: 116, Pages: 1913-23 (2006) [PubMed]

                  • The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis

                    Bergmeier, W.; Piffath, C. L.; Goerge, T.; Cifuni, S. M.; Ruggeri, Z. M.; Ware, J.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 103, Pages: 16900-5 (2006) [PubMed]

                  • Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

                    Kamath, A. F.; Chauhan, A. K.; Kisucka, J.; Dole, V. S.; Loscalzo, J.; Handy, D. E.; Wagner, D. D.

                    Blood, Volume: 107, Pages: 591-3 (2006) [PubMed]

                  • Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo

                    Yang, H.; Reheman, A.; Chen, P.; Zhu, G.; Hynes, R. O.; Freedman, J.; Wagner, D. D.; Ni, H.

                    J Thromb Haemost, Volume: 4, Pages: 2230-7 (2006) [PubMed]

                  • Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles

                    Matuskova, J.; Chauhan, A. K.; Cambien, B.; Astrof, S.; Dole, V. S.; Piffath, C. L.; Hynes, R. O.; Wagner, D. D.

                    Arterioscler Thromb Vasc Biol, Volume: 26, Pages: 1391-6 (2006) [PubMed]

                  • Inflammation.

                    Bergmeier W and Wagner DD.

                    In: Platelets. 2nd Edition. Michelson A (Ed.) San Diego: Elsevier – Academic Press (2006)

                  2005

                  (Back to Top)

                  • Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin

                    Dole, V. S.; Bergmeier, W.; Mitchell, H. A.; Eichenberger, S. C.; Wagner, D. D.

                    Blood, Volume: 106, Pages: 2334-9 (2005) [PubMed]

                  • Aspirin induces platelet receptor shedding via ADAM17 (TACE)

                    Aktas, B.; Pozgajova, M.; Bergmeier, W.; Sunnarborg, S.; Offermanns, S.; Lee, D.; Wagner, D. D.; Nieswandt, B.

                    J Biol Chem, Volume: 280, Pages: 39716-22 (2005) [PubMed]

                  • The P-selectin, tissue factor, coagulation triad

                    Polgar, J.; Matuskova, J.; Wagner, D. D.

                    J Thromb Haemost, Volume: 3, Pages: 1590-6 (2005) [PubMed]

                  • A direct role for C1 inhibitor in regulation of leukocyte adhesion

                    Cai, S.; Dole, V. S.; Bergmeier, W.; Scafidi, J.; Feng, H.; Wagner, D. D.; Davis, A. E., 3rd

                    J Immunol, Volume: 174, Pages: 6462-6 (2005) [PubMed]

                  • New links between inflammation and thrombosis

                    Wagner, D. D.

                    Arterioscler Thromb Vasc Biol, Volume: 25, Pages: 1321-4 (2005) [PubMed]

                  • Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice

                    Motto, D. G.; Chauhan, A. K.; Zhu, G.; Homeister, J.; Lamb, C. B.; Desch, K. C.; Zhang, W.; Tsai, H. M.; Wagner, D. D.; Ginsburg, D.

                    J Clin Invest, Volume: 115, Pages: 2752-61 (2005) [PubMed]

                  • Elevated soluble ICAM-1 levels induce immune deficiency and increase adiposity in mice

                    Wang, H. W.; Babic, A. M.; Mitchell, H. A.; Liu, K.; Wagner, D. D.

                    FASEB J, Volume: 19, Pages: 1018-20 (2005) [PubMed]

                  2004

                  (Back to Top)

                  • A new role in hemostasis for the adhesion receptor P-selectin

                    Cambien, B.; Wagner, D. D.

                    Trends Mol Med, Volume: 10, Pages: 179-86 (2004) [PubMed]

                  • ICAM-1 and beta2 integrin deficiency impairs fat oxidation and insulin metabolism during fasting

                    Babic, A. M.; Wang, H. W.; Lai, M. J.; Daniels, T. G.; Felbinger, T. W.; Burger, P. C.; Stricker-Krongrad, A.; Wagner, D. D.

                    Mol Med, Volume: 10, Pages: 72-9 (2004) [PubMed]

                  • CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

                    Crittenden, J. R.; Bergmeier, W.; Zhang, Y.; Piffath, C. L.; Liang, Y.; Wagner, D. D.; Housman, D. E.; Graybiel, A. M.

                    Nat Med, Volume: 10, Pages: 982-6 (2004) [PubMed]

                  • Mice lacking insulin or insulin-like growth factor 1 receptors in vascular endothelial cells maintain normal blood-brain barrier

                    Kondo, T.; Hafezi-Moghadam, A.; Thomas, K.; Wagner, D. D.; Kahn, C. R.

                    Biochem Biophys Res Commun, Volume: 317, Pages: 315-20 (2004) [PubMed]

                  • GPVI down-regulation in murine platelets through metalloproteinase-dependent shedding

                    Bergmeier, W.; Rabie, T.; Strehl, A.; Piffath, C. L.; Prostredna, M.; Wagner, D. D.; Nieswandt, B.

                    Thromb Haemost, Volume: 91, Pages: 951-8 (2004) [PubMed]

                  • Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo

                    Bergmeier, W.; Piffath, C. L.; Cheng, G.; Dole, V. S.; Zhang, Y.; von Andrian, U. H.; Wagner, D. D.

                    Circ Res, Volume: 95, Pages: 677-83 (2004) [PubMed]

                  • Structure, biology and genetics of von Willebrand factor.

                    Ginsburg D and Wagner DD.

                    In: Hematology: Basic Principles and Practices. 4th Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (2004)

                  2003

                  (Back to Top)

                  • Antithrombotic activity of TNF-alpha

                    Cambien, B.; Bergmeier, W.; Saffaripour, S.; Mitchell, H. A.; Wagner, D. D.

                    J Clin Invest, Volume: 112, Pages: 1589-96 (2003) [PubMed]

                  • Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor

                    Matsushita, K.; Morrell, C. N.; Cambien, B.; Yang, S. X.; Yamakuchi, M.; Bao, C.; Hara, M. R.; Quick, R. A.; Cao, W.; O'Rourke, B.; Lowenstein, J. M.; Pevsner, J.; Wagner, D. D.; Lowenstein, C. J.

                    Cell, Volume: 115, Pages: 139-50 (2003) [PubMed]

                  • The clearance mechanism of chilled blood platelets

                    Hoffmeister, K. M.; Felbinger, T. W.; Falet, H.; Denis, C. V.; Bergmeier, W.; Mayadas, T. N.; von Andrian, U. H.; Wagner, D. D.; Stossel, T. P.; Hartwig, J. H.

                    Cell, Volume: 112, Pages: 87-97 (2003) [PubMed]

                  • Plasma fibronectin promotes thrombus growth and stability in injured arterioles

                    Ni, H.; Yuen, P. S.; Papalia, J. M.; Trevithick, J. E.; Sakai, T.; Fassler, R.; Hynes, R. O.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 100, Pages: 2415-9 (2003) [PubMed]

                  • Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A

                    Hrachovinova, I.; Cambien, B.; Hafezi-Moghadam, A.; Kappelmayer, J.; Camphausen, R. T.; Widom, A.; Xia, L.; Kazazian, H. H., Jr.; Schaub, R. G.; McEver, R. P.; Wagner, D. D.

                    Nat Med, Volume: 9, Pages: 1020-5 (2003) [PubMed]

                  • P-selectin and leukocyte microparticles are associated with venous thrombogenesis

                    Myers, D. D.; Hawley, A. E.; Farris, D. M.; Wrobleski, S. K.; Thanaporn, P.; Schaub, R. G.; Wagner, D. D.; Kumar, A.; Wakefield, T. W.

                    J Vasc Surg, Volume: 38, Pages: 1075-89 (2003) [PubMed]

                  • Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets

                    Bergmeier, W.; Burger, P. C.; Piffath, C. L.; Hoffmeister, K. M.; Hartwig, J. H.; Nieswandt, B.; Wagner, D. D.

                    Blood, Volume: 102, Pages: 4229-35 (2003) [PubMed]

                  • Mechanisms and implications of platelet discoid shape

                    Italiano, J. E., Jr.; Bergmeier, W.; Tiwari, S.; Falet, H.; Hartwig, J. H.; Hoffmeister, K. M.; Andre, P.; Wagner, D. D.; Shivdasani, R. A.

                    Blood, Volume: 101, Pages: 4789-96 (2003) [PubMed]

                  • Platelets in inflammation and thrombosis

                    Wagner, D. D.; Burger, P. C.

                    Arterioscler Thromb Vasc Biol, Volume: 23, Pages: 2131-7 (2003) [PubMed]

                  • Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain

                    Ni, H.; Papalia, J. M.; Degen, J. L.; Wagner, D. D.

                    Blood, Volume: 102, Pages: 3609-14 (2003) [PubMed]

                  • Platelet P-selectin facilitates atherosclerotic lesion development

                    Burger, P. C.; Wagner, D. D.

                    Blood, Volume: 101, Pages: 2661-6 (2003) [PubMed]

                  • Shear madness in TNF-alpha signaling.

                    Wagner DD.

                    Blood, Volume: 102, Pages: 2711-2712 (2003)

                  2002

                  (Back to Top)

                  • Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha

                    Sethi, S.; Ziouzenkova, O.; Ni, H.; Wagner, D. D.; Plutzky, J.; Mayadas, T. N.

                    Blood, Volume: 100, Pages: 1340-6 (2002) [PubMed]

                  • Role of syndecan-1 in leukocyte-endothelial interactions in the ocular vasculature

                    Gotte, M.; Joussen, A. M.; Klein, C.; Andre, P.; Wagner, D. D.; Hinkes, M. T.; Kirchhof, B.; Adamis, A. P.; Bernfield, M.

                    Invest Ophthalmol Vis Sci, Volume: 43, Pages: 1135-41 (2002) [PubMed]

                  • CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism

                    Andre, P.; Prasad, K. S.; Denis, C. V.; He, M.; Papalia, J. M.; Hynes, R. O.; Phillips, D. R.; Wagner, D. D.

                    Nat Med, Volume: 8, Pages: 247-52 (2002) [PubMed]

                  2001

                  (Back to Top)

                  • Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models

                    Denis, C. V.; Kwack, K.; Saffaripour, S.; Maganti, S.; Andre, P.; Schaub, R. G.; Wagner, D. D.

                    Blood, Volume: 97, Pages: 465-72 (2001) [PubMed]

                  • Localized reduction of atherosclerosis in von Willebrand factor-deficient mice

                    Methia, N.; Andre, P.; Denis, C. V.; Economopoulos, M.; Wagner, D. D.

                    Blood, Volume: 98, Pages: 1424-8 (2001) [PubMed]

                  • ApoE deficiency compromises the blood brain barrier especially after injury

                    Methia, N.; Andre, P.; Hafezi-Moghadam, A.; Economopoulos, M.; Thomas, K. L.; Wagner, D. D.

                    Mol Med, Volume: 7, Pages: 810-5 (2001) [PubMed]

                  • Defect in regulated secretion of P-selectin affects leukocyte recruitment in von Willebrand factor-deficient mice

                    Denis, C. V.; Andre, P.; Saffaripour, S.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 98, Pages: 4072-7 (2001) [PubMed]

                  • Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice

                    Niederman, R.; Westernoff, T.; Lee, C.; Mark, L. L.; Kawashima, N.; Ullman-Culler, M.; Dewhirst, F. E.; Paster, B. J.; Wagner, D. D.; Mayadas, T.; Hynes, R. O.; Stashenko, P.

                    J Clin Periodontol, Volume: 28, Pages: 569-75 (2001) [PubMed]

                  • Increased thrombogenesis and embolus formation in mice lacking glycoprotein V

                    Ni, H.; Ramakrishnan, V.; Ruggeri, Z. M.; Papalia, J. M.; Phillips, D. R.; Wagner, D. D.

                    Blood, Volume: 98, Pages: 368-73 (2001) [PubMed]

                  2000

                  (Back to Top)

                  • Pro-coagulant state resulting from high levels of soluble P-selectin in blood

                    Andre, P.; Hartwell, D.; Hrachovinova, I.; Saffaripour, S.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 97, Pages: 13835-40 (2000) [PubMed]

                  • Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen

                    Ni, H.; Denis, C. V.; Subbarao, S.; Degen, J. L.; Sato, T. N.; Hynes, R. O.; Wagner, D. D.

                    J Clin Invest, Volume: 106, Pages: 385-92 (2000) [PubMed]

                  • Prominent role of P-selectin in the development of advanced atherosclerosis in ApoE-deficient mice

                    Dong, Z. M.; Brown, A. A.; Wagner, D. D.

                    Circulation, Volume: 101, Pages: 2290-5 (2000) [PubMed]

                  • Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins

                    Andre, P.; Denis, C. V.; Ware, J.; Saffaripour, S.; Hynes, R. O.; Ruggeri, Z. M.; Wagner, D. D.

                    Blood, Volume: 96, Pages: 3322-8 (2000) [PubMed]

                  • P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo

                    Frenette, P. S.; Denis, C. V.; Weiss, L.; Jurk, K.; Subbarao, S.; Kehrel, B.; Hartwig, J. H.; Vestweber, D.; Wagner, D. D.

                    J Exp Med, Volume: 191, Pages: 1413-22 (2000) [PubMed]

                  1999

                  (Back to Top)

                  • Insights from von Willebrand disease animal models

                    Denis, C. V.; Wagner, D. D.

                    Cell Mol Life Sci, Volume: 56, Pages: 977-90 (1999) [PubMed]

                  • Selective eosinophil transendothelial migration triggered by eotaxin via modulation of Mac-1/ICAM-1 and VLA-4/VCAM-1 interactions

                    Jia, G. Q.; Gonzalo, J. A.; Hidalgo, A.; Wagner, D.; Cybulsky, M.; Gutierrez-Ramos, J. C.

                    Int Immunol, Volume: 11, Pages: 1-10 (1999) [PubMed]

                  • New discoveries with mice mutant in endothelial and platelet selectins

                    Hartwell, D. W.; Wagner, D. D.

                    Thromb Haemost, Volume: 82, Pages: 850-7 (1999) [PubMed]

                  • Carboxypeptidase E does not mediate von Willebrand factor targeting to storage granules

                    Methia, N.; Denis, C. V.; Wagner, D. D.

                    Eur J Cell Biol, Volume: 78, Pages: 884-91 (1999) [PubMed]

                  • Donor MHC and adhesion molecules in transplant arteriosclerosis

                    Shi, C.; Feinberg, M. W.; Zhang, D.; Patel, A.; Sim, C. U.; Dong, Z. M.; Chapman, S. M.; Gutierrez-Ramos, J. C.; Wagner, D. D.; Sibinga, N. E.; Haber, E.

                    J Clin Invest, Volume: 103, Pages: 469-74 (1999) [PubMed]

                  • Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation

                    Enjyoji, K.; Sevigny, J.; Lin, Y.; Frenette, P. S.; Christie, P. D.; Esch, J. S., 2nd; Imai, M.; Edelberg, J. M.; Rayburn, H.; Lech, M.; Beeler, D. L.; Csizmadia, E.; Wagner, D. D.; Robson, S. C.; Rosenberg, R. D.

                    Nat Med, Volume: 5, Pages: 1010-7 (1999) [PubMed]

                  • P- and E-selectin-deficient mice are susceptible to cerebral ischemia-reperfusion injury

                    Soriano, S. G.; Wang, Y. F.; Wagner, D. D.; Frenette, P. S.

                    Brain Res, Volume: 835, Pages: 360-4 (1999) [PubMed]

                  • Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment

                    Robinson, S. D.; Frenette, P. S.; Rayburn, H.; Cummiskey, M.; Ullman-Cullere, M.; Wagner, D. D.; Hynes, R. O.

                    Proc Natl Acad Sci U S A, Volume: 96, Pages: 11452-7 (1999) [PubMed]

                  • Structure, biology and genetics of von Willebrand factor.

                    Ginsburg D and Wagner DD.

                    In: Hematology: Basic Principles and Practices. 3rd Edition. Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silberstein LE and McGlave P. (Eds.). New York: Churchill Livingstone (1999)

                  1998

                  (Back to Top)

                  • Platelet-endothelial interactions in inflamed mesenteric venules

                    Frenette, P. S.; Moyna, C.; Hartwell, D. W.; Lowe, J. B.; Hynes, R. O.; Wagner, D. D.

                    Blood, Volume: 91, Pages: 1318-24 (1998) [PubMed]

                  • A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis

                    Denis, C.; Methia, N.; Frenette, P. S.; Rayburn, H.; Ullman-Cullere, M.; Hynes, R. O.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 95, Pages: 9524-9 (1998) [PubMed]

                  • Angiogenesis in P- and E-selectin-deficient mice

                    Hartwell, D. W.; Butterfield, C. E.; Frenette, P. S.; Kenyon, B. M.; Hynes, R. O.; Folkman, J.; Wagner, D. D.

                    Microcirculation, Volume: 5, Pages: 173-8 (1998) [PubMed]

                  • Leukocyte-endothelium adhesion molecules in atherosclerosis

                    Dong, Z. M.; Wagner, D. D.

                    J Lab Clin Med, Volume: 132, Pages: 369-75 (1998) [PubMed]

                  • P-Selectin and platelet clearance

                    Berger, G.; Hartwell, D. W.; Wagner, D. D.

                    Blood, Volume: 92, Pages: 4446-52 (1998) [PubMed]

                  • The transmembrane domain enhances granular targeting of P-selectin

                    Fleming, J. C.; Berger, G.; Guichard, J.; Cramer, E. M.; Wagner, D. D.

                    Eur J Cell Biol, Volume: 75, Pages: 331-43 (1998) [PubMed]

                  • P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin

                    de Mora, F.; Williams, C. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Galli, S. J.

                    Lab Invest, Volume: 78, Pages: 497-505 (1998) [PubMed]

                  • The combined role of P- and E-selectins in atherosclerosis

                    Dong, Z. M.; Chapman, S. M.; Brown, A. A.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.

                    J Clin Invest, Volume: 102, Pages: 145-52 (1998) [PubMed]

                  • Endothelial selectins and vascular cell adhesion molecule-1 promote hematopoietic progenitor homing to bone marrow

                    Frenette, P. S.; Subbarao, S.; Mazo, I. B.; von Andrian, U. H.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 95, Pages: 14423-8 (1998) [PubMed]

                  • Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses

                    Hartwell, D. W.; Mayadas, T. N.; Berger, G.; Frenette, P. S.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.

                    J Cell Biol, Volume: 143, Pages: 1129-41 (1998) [PubMed]

                  • Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1

                    Mazo, I. B.; Gutierrez-Ramos, J. C.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; von Andrian, U. H.

                    J Exp Med, Volume: 188, Pages: 465-74 (1998) [PubMed]

                  • Leukocytes fighting against obesity

                    Dong, Z. M.; Wagner, D. D.

                    Mol Psychiatry, Volume: 3, Pages: 8-9 (1998) [PubMed]

                  • E and P selectins are not required for resistance to severe murine lyme arthritis

                    Seiler, K. P.; Ma, Y.; Weis, J. H.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Weis, J. J.

                    Infect Immun, Volume: 66, Pages: 4557-9 (1998) [PubMed]

                  • Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation

                    Homeister, J. W.; Zhang, M.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Lowe, J. B.; Marks, R. M.

                    Blood, Volume: 92, Pages: 2345-52 (1998) [PubMed]

                  1997

                  (Back to Top)

                  • Genetic manipulation of vascular adhesion molecules in mice

                    Hynes, R. O.; Wagner, D. D.

                    J Clin Invest, Volume: 100, Pages: S11-3 (1997) [PubMed]

                  • A new class of obesity genes encodes leukocyte adhesion receptors

                    Dong, Z. M.; Gutierrez-Ramos, J. C.; Coxon, A.; Mayadas, T. N.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 94, Pages: 7526-30 (1997) [PubMed]

                  • Role of endothelial selectins in wound repair

                    Subramaniam, M.; Saffaripour, S.; Van De Water, L.; Frenette, P. S.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D.

                    Am J Pathol, Volume: 150, Pages: 1701-9 (1997) [PubMed]

                  • Insights into selectin function from knockout mice

                    Frenette, P. S.; Wagner, D. D.

                    Thromb Haemost, Volume: 78, Pages: 60-4 (1997) [PubMed]

                  • Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin

                    Walter, U. M.; Ayer, L. M.; Manning, A. M.; Frenette, P. S.; Wagner, D. D.; Hynes, R. O.; Wolitzky, B. A.; Issekutz, A. C.

                    Hybridoma, Volume: 16, Pages: 355-61 (1997) [PubMed]

                  • Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse

                    Walter, U. M.; Ayer, L. M.; Wolitzky, B. A.; Wagner, D. D.; Hynes, R. O.; Manning, A. M.; Issekutz, A. C.

                    Hybridoma, Volume: 16, Pages: 249-57 (1997) [PubMed]

                  • Experimental murine acid aspiration injury is mediated by neutrophils and the alternative complement pathway

                    Weiser, M. R.; Pechet, T. T.; Williams, J. P.; Ma, M.; Frenette, P. S.; Moore, F. D.; Kobzik, L.; Hines, R. O.; Wagner, D. D.; Carroll, M. C.; Hechtman, H. B.

                    J Appl Physiol, Volume: 83, Pages: 1090-5 (1997) [PubMed]

                  • Absence of P-selectin delays fatty streak formation in mice

                    Johnson, R. C.; Chapman, S. M.; Dong, Z. M.; Ordovas, J. M.; Mayadas, T. N.; Herz, J.; Hynes, R. O.; Schaefer, E. J.; Wagner, D. D.

                    J Clin Invest, Volume: 99, Pages: 1037-43 (1997) [PubMed]

                  1996

                  (Back to Top)

                  • Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins

                    Tang, T.; Frenette, P. S.; Hynes, R. O.; Wagner, D. D.; Mayadas, T. N.

                    J Clin Invest, Volume: 97, Pages: 2485-90 (1996) [PubMed]

                  • Defects in hemostasis in P-selectin-deficient mice

                    Subramaniam, M.; Frenette, P. S.; Saffaripour, S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D.

                    Blood, Volume: 87, Pages: 1238-42 (1996) [PubMed]

                  • Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation

                    Pinsky, D. J.; Naka, Y.; Liao, H.; Oz, M. C.; Wagner, D. D.; Mayadas, T. N.; Johnson, R. C.; Hynes, R. O.; Heath, M.; Lawson, C. A.; Stern, D. M.

                    J Clin Invest, Volume: 97, Pages: 493-500 (1996) [PubMed]

                  • Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice

                    Mayadas, T. N.; Mendrick, D. L.; Brady, H. R.; Tang, T.; Papayianni, A.; Assmann, K. J.; Wagner, D. D.; Hynes, R. O.; Cotran, R. S.

                    Kidney Int, Volume: 49, Pages: 1342-9 (1996) [PubMed]

                  • Adhesion molecules--Part 1

                    Frenette, P. S.; Wagner, D. D.

                    N Engl J Med, Volume: 334, Pages: 1526-9 (1996) [PubMed]

                  • Genetic manipulation of vascular adhesion molecules in mice

                    Hynes, R. O.; Wagner, D. D.

                    J Clin Invest, Volume: 98, Pages: 2193-5 (1996) [PubMed]

                  • Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins

                    Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.

                    Cell, Volume: 84, Pages: 563-74 (1996) [PubMed]

                  • Adhesion molecules--Part II: Blood vessels and blood cells

                    Frenette, P. S.; Wagner, D. D.

                    N Engl J Med, Volume: 335, Pages: 43-5 (1996) [PubMed]

                  • Double knockout highlights value of endothelial selectins

                    Frenette, P. S.; Mayadas, T. N.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.

                    Immunol Today, Volume: 17, Pages: 205 (1996) [PubMed]

                  1995

                  (Back to Top)

                  • Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin

                    Yamada, S.; Mayadas, T. N.; Yuan, F.; Wagner, D. D.; Hynes, R. O.; Melder, R. J.; Jain, R. K.

                    Blood, Volume: 86, Pages: 3487-92 (1995) [PubMed]

                  • Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin

                    Frenette, P. S.; Johnson, R. C.; Hynes, R. O.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 92, Pages: 7450-4 (1995) [PubMed]

                  • Blood cell dynamics in P-selectin-deficient mice

                    Johnson, R. C.; Mayadas, T. N.; Frenette, P. S.; Mebius, R. E.; Subramaniam, M.; Lacasce, A.; Hynes, R. O.; Wagner, D. D.

                    Blood, Volume: 86, Pages: 1106-14 (1995) [PubMed]

                  • P-selectin knockout: a mouse model for various human diseases

                    Wagner, D. D.

                    Ciba Found Symp, Volume: 189, Pages: 2-10; discussion 10-16, 77-8 (1995) [PubMed]

                  • P-selectin chases a butterfly

                    Wagner, D. D.

                    J Clin Invest, Volume: 95, Pages: 1955-6 (1995) [PubMed]

                  • Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice

                    Subramaniam, M.; Saffaripour, S.; Watson, S. R.; Mayadas, T. N.; Hynes, R. O.; Wagner, D. D.

                    J Exp Med, Volume: 181, Pages: 2277-82 (1995) [PubMed]

                  • Structure, biology and genetics of von Willebrand factor.

                    Wagner DD and Ginsburg D.

                    In: Hematology: Basic Principles and Practices. 2nd Edition. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1717-1725 (1995)

                  • Gene targeting of adhesion molecules in the vasculature.

                    Wagner DD and Hynes RO.

                    In: Series: Molecular genetics and gene therapy of cardiovascular diseases. Mockrin SC (Ed.) New York: Marcel Dekker., Pages: 403-405 (1995)

                  • P-selectin-deficient mice: A model to study inflammation and metastasis.

                    In: Series: Topics in Molecular Medicine Vol 1. Siess W, Lorenz R and Weber PC. (Eds.). New York: Raven Press., Pages: 105-116 (1995)

                  1994

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                  • von Willebrand factor proteolytic processing and multimerization precede the formation of Weibel-Palade bodies

                    Vischer, U. M.; Wagner, D. D.

                    Blood, Volume: 83, Pages: 3536-44 (1994) [PubMed]

                  1993

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                  • P-selectin mediates adhesion of platelets to neuroblastoma and small cell lung cancer

                    Stone, J. P.; Wagner, D. D.

                    J Clin Invest, Volume: 92, Pages: 804-13 (1993) [PubMed]

                  • Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

                    Mayadas, T. N.; Johnson, R. C.; Rayburn, H.; Hynes, R. O.; Wagner, D. D.

                    Cell, Volume: 74, Pages: 541-54 (1993) [PubMed]

                  • Divergent fates of P- and E-selectins after their expression on the plasma membrane

                    Subramaniam, M.; Koedam, J. A.; Wagner, D. D.

                    Mol Biol Cell, Volume: 4, Pages: 791-801 (1993) [PubMed]

                  • von Willebrand factor storage requires intact prosequence cleavage site

                    Journet, A. M.; Saffaripour, S.; Cramer, E. M.; Tenza, D.; Wagner, D. D.

                    Eur J Cell Biol, Volume: 60, Pages: 31-41 (1993) [PubMed]

                  • CD63 is a component of Weibel-Palade bodies of human endothelial cells

                    Vischer, U. M.; Wagner, D. D.

                    Blood, Volume: 82, Pages: 1184-91 (1993) [PubMed]

                  • The Weibel-Palade body: the storage granule for von Willebrand factor and P-selectin

                    Wagner, D. D.

                    Thromb Haemost, Volume: 70, Pages: 105-10 (1993) [PubMed]

                  • Requirement for both D domains of the propolypeptide in von Willebrand factor multimerization and storage

                    Journet, A. M.; Saffaripour, S.; Wagner, D. D.

                    Thromb Haemost, Volume: 70, Pages: 1053-7 (1993) [PubMed]

                  1992

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                  • P-selectin, a granule membrane protein of platelets and endothelial cells, follows the regulated secretory pathway in AtT-20 cells

                    Koedam, J. A.; Cramer, E. M.; Briend, E.; Furie, B.; Furie, B. C.; Wagner, D. D.

                    J Cell Biol, Volume: 116, Pages: 617-25 (1992) [PubMed]

                  • Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly

                    Mayadas, T. N.; Wagner, D. D.

                    Proc Natl Acad Sci U S A, Volume: 89, Pages: 3531-5 (1992) [PubMed]

                  • A 130-kDa protein on endothelial cells binds to amino acids 15-42 of the B beta chain of fibrinogen

                    Erban, J. K.; Wagner, D. D.

                    J Biol Chem, Volume: 267, Pages: 2451-8 (1992) [PubMed]

                  • P-selectin and E-selectin. Distinct but overlapping leukocyte ligand specificities

                    Larsen, G. R.; Sako, D.; Ahern, T. J.; Shaffer, M.; Erban, J.; Sajer, S. A.; Gibson, R. M.; Wagner, D. D.; Furie, B. C.; Furie, B.

                    J Biol Chem, Volume: 267, Pages: 11104-10 (1992) [PubMed]

                  1991

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                  • Induction of specific storage organelles by von Willebrand factor propolypeptide

                    Wagner, D. D.; Saffaripour, S.; Bonfanti, R.; Sadler, J. E.; Cramer, E. M.; Chapman, B.; Mayadas, T. N.

                    Cell, Volume: 64, Pages: 403-13 (1991) [PubMed]

                  • PADGEM, a leukocyte receptor on activated platelets. Biology and application to in vivo medical diagnostics

                    Furie, B.; Celi, A.; Palabrica, T. M.; Larsen, E.; Wagner, D. D.; Furie, B. C.

                    Curr Stud Hematol Blood Transfus, Pages: 32-6 (1991) [PubMed]

                  • von Willebrand factor and the endothelium

                    Wagner, D. D.; Bonfanti, R.

                    Mayo Clin Proc, Volume: 66, Pages: 621-7 (1991) [PubMed]

                  • von Willebrand factor biosynthesis and processing

                    Mayadas, T. N.; Wagner, D. D.

                    Ann N Y Acad Sci, Volume: 614, Pages: 153-66 (1991) [PubMed]

                  • PADGEM a Leukocyte Receptor on Activated Platelets: Biology and application to in vivo medical diagnostics.

                    Furie B, Celi A, Palabrica TM, Larsen E, Wagner DD and Furie, BC.

                    In: Biotechnology of Plasma Proteins: Haemostasis, Thrombosis and Iron Proteins. Albertini A, L’Enfant CL, Mannucci PM, and Sixma JJ. (Eds). Basel: Karger., Pages: 32-36. (1991)

                  • Selectins: A family of adhesion receptors. Letter to the Editor.

                    Bevilacqua E, Butcher E, Furie B, Furie B, Gallatin M, Gimbrone M, Harlan J, Kishimoto K, Lasky L, McEver R, Paulson J, Rosen S, Seed B, Siegelman M, Springer T, Stoolman L, Tedder T, Varki A, Wagner D, Weissman I and Zimmerman G.

                    Cell., Volume: 67., Pages: 233. (1991)

                  • Structure and biology of von Willebrand factor.

                    Wagner DD.

                    In: Hematology: Basic Principles and Practices. Benz EJ, Cohen HJ, Furie B, Hoffman R and Shattil SJ. (Eds.). New York: Churchill Livingstone., Pages: 1354-1358. (1991)

                  1990

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                  • Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1)

                    Peters, J. H.; Sporn, L. A.; Ginsberg, M. H.; Wagner, D. D.

                    Blood, Volume: 75, Pages: 1801-8 (1990) [PubMed]

                  • Cell biology of von Willebrand factor

                    Wagner, D. D.

                    Annu Rev Cell Biol, Volume: 6, Pages: 217-46 (1990) [PubMed]

                  • PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15)

                    Larsen, E.; Palabrica, T.; Sajer, S.; Gilbert, G. E.; Wagner, D. D.; Furie, B. C.; Furie, B.

                    Cell, Volume: 63, Pages: 467-74 (1990) [PubMed]

                  1989

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                  • In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls

                    Mayadas, T. N.; Wagner, D. D.

                    J Biol Chem, Volume: 264, Pages: 13497-503 (1989) [PubMed]

                  • PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes

                    Larsen, E.; Celi, A.; Gilbert, G. E.; Furie, B. C.; Erban, J. K.; Bonfanti, R.; Wagner, D. D.; Furie, B.

                    Cell, Volume: 59, Pages: 305-12 (1989) [PubMed]

                  • von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation

                    Mayadas, T.; Wagner, D. D.; Simpson, P. J.

                    Blood, Volume: 73, Pages: 706-11 (1989) [PubMed]

                  • Molecular and cellular biology of von Willebrand factor

                    Handin, R. I.; Wagner, D. D.

                    Prog Hemost Thromb, Volume: 9, Pages: 233-59 (1989) [PubMed]

                  • PADGEM (GMP140) is a component of Weibel-Palade bodies of human endothelial cells

                    Bonfanti, R.; Furie, B. C.; Furie, B.; Wagner, D. D.

                    Blood, Volume: 73, Pages: 1109-12 (1989) [PubMed]

                  • Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells

                    Sporn, L. A.; Marder, V. J.; Wagner, D. D.

                    J Cell Biol, Volume: 108, Pages: 1283-9 (1989) [PubMed]

                  • Plasma selenium-dependent glutathione peroxidase. Cell of origin and secretion

                    Avissar, N.; Whitin, J. C.; Allen, P. Z.; Wagner, D. D.; Liegey, P.; Cohen, H. J.

                    J Biol Chem, Volume: 264, Pages: 15850-5 (1989) [PubMed]

                  • Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain

                    Ribes, J. A.; Ni, F.; Wagner, D. D.; Francis, C. W.

                    J Clin Invest, Volume: 84, Pages: 435-42 (1989) [PubMed]

                  • Temperature-sensitive steps in the secretory pathway for von Willebrand factor in endothelial cells

                    Roarke, M. C.; Wagner, D. D.; Marder, V. J.; Sporn, L. A.

                    Eur J Cell Biol, Volume: 48, Pages: 337-43 (1989) [PubMed]

                  • Storage and secretion of von Willebrand factor.

                    Wagner DD.

                    In: Role of Factor VIII and von Willebrand Factor. Zimmerman TS and Ruggeri ZM. (Eds.). New York: Marcel Dekker., Pages: 161-180. (1989)

                  1987

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                  • Topology and order of formation of interchain disulfide bonds in von Willebrand factor

                    Wagner, D. D.; Lawrence, S. O.; Ohlsson-Wilhelm, B. M.; Fay, P. J.; Marder, V. J.

                    Blood, Volume: 69, Pages: 27-32 (1987) [PubMed]

                  • Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells

                    Wagner, D. D.; Fay, P. J.; Sporn, L. A.; Sinha, S.; Lawrence, S. O.; Marder, V. J.

                    Proc Natl Acad Sci U S A, Volume: 84, Pages: 1955-9 (1987) [PubMed]

                  • Intact microtubules are necessary for complete processing, storage and regulated secretion of von Willebrand factor by endothelial cells

                    Sinha, S.; Wagner, D. D.

                    Eur J Cell Biol, Volume: 43, Pages: 377-83 (1987) [PubMed]

                  • von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively

                    Sporn, L. A.; Marder, V. J.; Wagner, D. D.

                    Blood, Volume: 69, Pages: 1531-4 (1987) [PubMed]

                  • Fibrin induces release of von Willebrand factor from endothelial cells

                    Ribes, J. A.; Francis, C. W.; Wagner, D. D.

                    J Clin Invest, Volume: 79, Pages: 117-23 (1987) [PubMed]

                  1986

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                  • Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II

                    Fay, P. J.; Kawai, Y.; Wagner, D. D.; Ginsburg, D.; Bonthron, D.; Ohlsson-Wilhelm, B. M.; Chavin, S. I.; Abraham, G. N.; Handin, R. I.; Orkin, S. H.; et al.,

                    Science, Volume: 232, Pages: 995-8 (1986) [PubMed]

                  • Inducible secretion of large, biologically potent von Willebrand factor multimers

                    Sporn, L. A.; Marder, V. J.; Wagner, D. D.

                    Cell, Volume: 46, Pages: 185-90 (1986) [PubMed]

                  • Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor

                    Wagner, D. D.; Mayadas, T.; Marder, V. J.

                    J Cell Biol, Volume: 102, Pages: 1320-4 (1986) [PubMed]

                  1985

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                  • Biosynthesis of von Willebrand protein by human megakaryocytes

                    Sporn, L. A.; Chavin, S. I.; Marder, V. J.; Wagner, D. D.

                    J Clin Invest, Volume: 76, Pages: 1102-6 (1985) [PubMed]

                  • Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers

                    Wagner, D. D.; Mayadas, T.; Urban-Pickering, M.; Lewis, B. H.; Marder, V. J.

                    J Cell Biol, Volume: 101, Pages: 112-20 (1985) [PubMed]

                  1984

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                  • Von Willebrand protein binds to extracellular matrices independently of collagen

                    Wagner, D. D.; Urban-Pickering, M.; Marder, V. J.

                    Proc Natl Acad Sci U S A, Volume: 81, Pages: 471-5 (1984) [PubMed]

                  • Irradiation induces release of von Willebrand protein from endothelial cells in culture

                    Sporn, L. A.; Rubin, P.; Marder, V. J.; Wagner, D. D.

                    Blood, Volume: 64, Pages: 567-70 (1984) [PubMed]

                  • Biosynthesis of von Willebrand protein by human endothelial cells: processing steps and their intracellular localization

                    Wagner, D. D.; Marder, V. J.

                    J Cell Biol, Volume: 99, Pages: 2123-30 (1984) [PubMed]

                  1983

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                  • Biosynthesis of von Willebrand protein by human endothelial cells. Identification of a large precursor polypeptide chain

                    Wagner, D. D.; Marder, V. J.

                    J Biol Chem, Volume: 258, Pages: 2065-7 (1983) [PubMed]

                  1982

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                  • Relationships between microfilaments, cell-substratum adhesion, and fibronectin

                    Hynes, R. O.; Destree, A. T.; Wagner, D. D.

                    Cold Spring Harb Symp Quant Biol, Volume: 46 Pt 2, Pages: 659-70 (1982) [PubMed]

                  • Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

                    Wagner, D. D.; Olmsted, J. B.; Marder, V. J.

                    J Cell Biol, Volume: 95, Pages: 355-60 (1982) [PubMed]

                  • Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles

                    Wagner, D. D.; Hynes, R. O.

                    Exp Cell Res, Volume: 140, Pages: 373-81 (1982) [PubMed]

                  • Fibronectin dependent endocytosis by macrophage like (P388D1) and fibroblastic (NIL 8) cells.

                    Van De Water L III, Wagner DD, Crenshaw EB III and Hynes RO.

                    In: Cellular Recognition. Glaser L, Frazier W and Gottlieb D (Eds.). New York: Alan R. Liss., Pages: 869-878 (1982)

                  1981

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                  • Similarities and differences between the fibronectins of normal and transformed hamster cells

                    Wagner, D. D.; Ivatt, R.; Destree, A. T.; Hynes, R. O.

                    J Biol Chem, Volume: 256, Pages: 11708-15 (1981) [PubMed]

                  1980

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                  • Topological arrangement of the major structural features of fibronectin

                    Wagner, D. D.; Hynes, R. O.

                    J Biol Chem, Volume: 255, Pages: 4304-12 (1980) [PubMed]

                  1979

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                  • Cell surface fibronectin and oncogenic transformation

                    Hynes, R. O.; Destree, A. T.; Perkins, M. E.; Wagner, D. D.

                    J Supramol Struct, Volume: 11, Pages: 95-104 (1979) [PubMed]

                  • Domain structure of fibronectin and its relation to function. Disulfides and sulfhydryl groups

                    Wagner, D. D.; Hynes, R. O.

                    J Biol Chem, Volume: 254, Pages: 6746-54 (1979) [PubMed]

                  1978

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                  • A large glycoprotein lost from the surfaces of transformed cells

                    Hynes, R. O.; Ali, I. U.; Destree, A. T.; Mautner, V.; Perkins, M. E.; Senger, D. R.; Wagner, D. D.; Smith, K. K.

                    Ann N Y Acad Sci, Volume: 312, Pages: 317-42 (1978) [PubMed]

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