Selected publications
2021
Sugden WW, North TE. Making Blood from the Vessel: Extrinsic and Environmental Cues Guiding the Endothelial-to-Hematopoietic Transition. Life (Basel). 2021 Sep 29;11(10):1027. doi: 10.3390/life11101027. PMID: 34685398; PMCID: PMC8539454.
Osborne JK, Kinney MA, Han A, Akinnola KE, Yermalovich AV, Vo LT, Pearson DS, Sousa PM, Ratanasirintrawoot S, Tsanov KM, Barragan J, North TE, Metzger RJ, Daley GQ. Lin28 paralogs regulate lung branching morphogenesis. Cell Rep. 2021 Jul 20;36(3):109408. doi: 10.1016/j.celrep.2021.109408. PMID: 34289374; PMCID: PMC8371695.
Soto RA, Najia MAT, Hachimi M, Frame JM, Yette GA, Lummertz da Rocha E, Stankunas K, Daley GQ, North TE. Sequential regulation of hemogenic fate and hematopoietic stem and progenitor cell formation from arterial endothelium by Ezh1/2. Stem Cell Reports. 2021 Jul 13;16(7):1718-1734. doi: 10.1016/j.stemcr.2021.05.014. Epub 2021 Jun 17. PMID: 34143974; PMCID: PMC8282472.
Frame JM, North TE. Ddx41 loss R-loops in cGAS to fuel inflammatory HSPC production. Dev Cell. 2021 Mar 8;56(5):571-572. doi: 10.1016/j.devcel.2021.02.014. PMID: 33689767.
2020
Chaturantabut S, Shwartz A, Garnaas MK, LaBella K, Li CC, Carroll KJ, Cutting CC, Budrow N, Palaria A, Gorelick DA, Tremblay KD, North TE, Goessling W. Estrogen Acts Through Estrogen Receptor 2b to Regulate Hepatobiliary Fate During Vertebrate Development. Hepatology. 2020 Nov;72(5):1786-1799. doi: 10.1002/hep.31184. PMID: 32060934; PMCID: PMC8290048.
Marion W, Boettcher S, Ruiz-Torres S, Lummertz da Rocha E, Lundin V, Morris V, Chou S, Zhao AM, Kubaczka C, Aumais O, Zhang Y, Shimamura A, Schlaeger TM, North TE, Ebert BL, Wells SI, Daley GQ, Rowe RG. An induced pluripotent stem cell model of Fanconi anemia reveals mechanisms of p53-driven progenitor cell differentiation. Blood Adv. 2020 Oct 13;4(19):4679-4692. doi: 10.1182/bloodadvances.2020001593. PMID: 33002135; PMCID: PMC7556119.
Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, North TE. Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production. Dev Cell. 2020 Oct 26;55(2):133-149.e6. doi: 10.1016/j.devcel.2020.07.015. Epub 2020 Aug 17. PMID: 32810442; PMCID: PMC8008739.
Chen MJ, Lummertz da Rocha E, Cahan P, Kubaczka C, Hunter P, Sousa P, Mullin NK, Fujiwara Y, Nguyen M, Tan Y, Landry S, Han A, Yang S, Lu YF, Jha DK, Vo LT, Zhou Y, North TE, Zon LI, Daley GQ, Schlaeger TM. Transcriptome Dynamics of Hematopoietic Stem Cell Formation Revealed Using a Combinatorial Runx1 and Ly6a Reporter System. Stem Cell Reports. 2020 May 12;14(5):956-971. doi: 10.1016/j.stemcr.2020.03.020. Epub 2020 Apr 16. PMID: 32302558; PMCID: PMC7220988.
Lundin V, Sugden WW, Theodore LN, Sousa PM, Han A, Chou S, Wrighton PJ, Cox AG, Ingber DE, Goessling W, Daley GQ, North TE. YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow. Dev Cell. 2020 Feb 24;52(4):446-460.e5. doi: 10.1016/j.devcel.2020.01.006. Epub 2020 Feb 6. PMID: 32032546; PMCID: PMC7398148.
2019
Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering. Nat Biotechnol. 2019 Aug;37(8):962. doi: 10.1038/s41587-019-0212-1. Erratum for: Nat Biotechnol. 2019 Jul;37(7):810-818. PMID: 31312048.
Kinney MA, Vo LT, Frame JM, Barragan J, Conway AJ, Li S, Wong KK, Collins JJ, Cahan P, North TE, Lauffenburger DA, Daley GQ. A systems biology pipeline identifies regulatory networks for stem cell engineering. Nat Biotechnol. 2019 Jul;37(7):810-818. doi: 10.1038/s41587-019-0159-2. Epub 2019 Jul 1. Erratum in: Nat Biotechnol. 2019 Aug;37(8):962. PMID: 31267104; PMCID: PMC7235931.
Rowe RG, Lummertz da Rocha E, Sousa P, Missios P, Morse M, Marion W, Yermalovich A, Barragan J, Mathieu R, Jha DK, Fleming MD, North TE, Daley GQ. The developmental stage of the hematopoietic niche regulates lineage in MLL-rearranged leukemia. J Exp Med. 2019 Mar 4;216(3):527-538. doi: 10.1084/jem.20181765. Epub 2019 Feb 6. PMID: 30728174; PMCID: PMC6400531.
Chaturantabut S, Shwartz A, Evason KJ, Cox AG, Labella K, Schepers AG, Yang S, Acuña M, Houvras Y, Mancio-Silva L, Romano S, Gorelick DA, Cohen DE, Zon LI, Bhatia SN, North TE, Goessling W. Estrogen Activation of G-Protein-Coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-Kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 2019 May;156(6):1788-1804.e13. doi: 10.1053/j.gastro.2019.01.010. Epub 2019 Jan 12. PMID: 30641053; PMCID: PMC6532055.
2018
Lummertz da Rocha E, Rowe RG, Lundin V, Malleshaiah M, Jha DK, Rambo CR, Li H, North TE, Collins JJ, Daley GQ. Reconstruction of complex single-cell trajectories using CellRouter. Nat Commun. 2018 Mar 1;9(1):892. doi: 10.1038/s41467-018-03214-y. PMID: 29497036; PMCID: PMC5832860.
Vo LT, Kinney MA, Liu X, Zhang Y, Barragan J, Sousa PM, Jha DK, Han A, Cesana M, Shao Z, North TE, Orkin SH, Doulatov S, Xu J, Daley GQ. Regulation of embryonic haematopoietic multipotency by EZH1. Nature. 2018 Jan 17. doi: 10.1038/nature25435. [Epub ahead of print]
Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells. Leuk Lymphoma. 2018 Sep;59(9):2188-2200. doi: 10.1080/10428194.2017.1410882. Epub 2017 Dec 18. PMID: 29249175; PMCID: PMC6005736.
2017
Lim SE, Esain V, Kwan W, Theodore LN, Cortes M, Frost IM, Liu SY, and North TE. HIF1a-induced PDGFRb signaling promotes developmental HSC production via IL-6 activation. 2017. Experimental Hematology. 46: 83-95
Theodore LN*, Hagedorn EJ*, Cortes M*, Natsuhara KH, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI and North TE. Distinct Roles for Matrix Metalloproteinase 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration and Niche Colonization. 2017. Stem Cell Reports 8(5): 1226-1241.
Oo ZM, Illendula A, Grembecka J, Schmidt C, Zhou Y, Esain V, Kwan W, Frost I, North TE, Rajewski RA, Speck NA, Bushweller JH. A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ in leukemic cells. Leuk Lymphoma. 2017 Dec 18:1-13. doi: 10.1080/10428194.2017.1410882. [Epub ahead of print]
Theodore LN, Hagedorn EJ, Cortes M, Natsuhara K, Liu SY, Perlin JR, Yang S, Daily ML, Zon LI, North TE. Distinct Roles for Matrix Metalloproteinases 2 and 9 in Embryonic Hematopoietic Stem Cell Emergence, Migration, and Niche Colonization. Stem Cell Reports. 2017 May 9;8(5):1226-1241. doi: 10.1016/j.stemcr.2017.03.016. Epub 2017 Apr 13.
Lim SE, Esain V, Kwan W, Theodore LN, Cortes M, Frost IM, Liu SY, North TE. HIF1α-induced PDGFRβ signaling promotes developmental HSC production via IL-6 activation. Exp Hematol. 2017 Feb;46:83-95.e6. doi: 10.1016/j.exphem.2016.10.002. Epub 2016 Oct 15.
Reviews:
Kwan W and North TE. Netting Novel Regulators of Hematopoiesis and Hematologic Malignancies in Zebrafish. Curr Top Dev Biol. 2017;124:125-160.
Frame JM, Lim SE, North TE. Hematopoietic stem cell development: Using the zebrafish to identify extrinsic and intrinsic mechanisms regulating hematopoiesis. Methods Cell Biol. 2017;138:165-192.