In applying precision medicine to vaccinology, the PVP employs several emerging concepts, approaches, and technologies that accelerate and de-risk development of vaccines tailored for distinct populations:
- Human in vitro modeling
- Systems biology
- Use of big data/global molecular/OMIC approaches to characterize molecular signatures for vaccine correlates of protection
- Discovery and development of adjuvants, small molecules and other bioactives that can boost immune responses in a population specific manner
- We are currently working on vaccines against:
- SARS-CoV-2
- Human Immunodeficiency Virus (HIV)
- Respiratory SyncytialVirus (RSV)
- Influenza
- Pertussis (whooping cough)
- Opioid vaccines to prevent overdose
![Discovery and development of precision vaccines may include a series of sequential approaches including system biology analysis of biosamples from clinical trials to define vaccine-induced cellular and molecular signatures that correlate with immunogenicity, thereby generating new mechanistic hypotheses; use of human in vitro systems for hypothesis testing and targeted adjuvant discovery employing population-specific biosamples, selection of appropriate animal models and clinical trials in specific vulnerable populations.](/sites/default/files/inline-images/PVP-Approach-Infographic.jpg)