Principal investigator
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Frederick Alt, PhD
Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital Charles A. Janeway Professor of Pediatrics Professor of Genetics, Harvard Medical School |
Assistant Professor
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Ming Tian, PhD Harvard University I generate mouse models to test HIV-1 vaccine candidates. The goal of HIV-1 vaccine development is to design immunization methods that can elicit broadly neutralizing antibodies against diverse viral strains. Our mouse models express precursors of broadly neutralizing antibodies. Immunization of these mouse models can evaluate the ability of the vaccine candidate to mature the precursor antibody into broadly neutralizing antibodies. |
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Yongxin Ye, PhD Peking University, China I am an Assistant Professor specializing in bioinformatics, with expertise in bioinformatics analysis and biostatistical modeling. Currently, my primary focus is on analyzing next-generation sequencing (NGS) data, including high-throughput genome-wide translocation sequencing (HTGTS), generated by lab, to characterize V(D)J recombination, somatic hypermutation, and class switch recombination during B cell development. I am also interested in exploring artificial intelligence (AI) applications, such as ChatGPT, in many fields, including bioinformatics. |
Instructors
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Hongli Hu, PhD University of Chinese Academy of Sciences My current research is focus on cohesion unloader Wapl's function in V(D)J recombination.
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Postdoctoral Fellows
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Himanshu Batra I am interested in generating mouse models for obtaining novel broadly neutralizing antibodies to COVID-19 and HIV. In addition to that, I am studying the regulatory mechanisms of immunoglobulin light chain isotypic exclusion in B cells.
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Xi Chen My study focus on studying the mechanism of somatic hypermutation by using cell lines.
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Xiang Li My research is focused on the mechanism of V(D)J recombination and IgH allelic exclusion in developing B cells |
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Aseda Tena I am interested in identifying mechanisms in brain neural progenitor cells that contribute to recurrent DNA breaks in a set of genes implicated in neuropsychiatric diseases and cancer. |
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Chengxian Xu My study is going to reveal the mechanisms of V(D)J recombination during B cell development. File upload |
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Zhuo Yang My research is focused on elucidating the mechanism of chromatin loop extrusion-mediated class switch recombination. |
Graduate Students
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Yiwen Zhang PhD student in Biological and Biomedical Sciences (BBS), Harvard University I am interested in studying the regulatory mechanisms of chromatin 3D structure in the context of IgH V(D)J recombination in progenitor B cells. |
Staff
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David Chen Research Assistant I
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Hwei-Ling Cheng Lab Manager/Research Specialist III |
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Vera Gaun PCMM Program Coordinator |
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Geeyoun Jung Research Assistant I
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Xin Lin Bioinformatics Research Assistant III |
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Judy Needham Administrative Assistant
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Barbara de Oliveria Research Assistant I
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Yumi Uetake Senior Laboratory Manager
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Aimee Williams Lead Research Technologist
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Taimor Williams Bioinformatic Research Assistant I
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Tammie Zhu Research Assistant I
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