The focus of the Chiarle Laboratory is on the mechanisms and therapy of cancers. By exploiting genome-wide approaches, we aim at understanding the general principles that govern the formation of chromosomal translocations in cancers and their therapeutic vulnerabilities. In translational efforts, we are developing innovative immunotherapies for tumors, including a vaccine to elicit strong and specific immune responses against tumors that express ALK and ALK-specific chimeric antigen receptor (CAR) T cells.
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