Publications | Overview
Recent publications
Zhang L, Hom N, Ojha A, Lovendahl KN, Mou H, Lee KK, Choe H. Cytoplasmic tail truncation stabilizes S1-S2 association and enhances S protein incorporation into SARS-CoV-2 pseudovirions. J Virol. 2023 Mar; 97(3): e01650-22. https://doi.org/10.1128/jvi.01650-22
Jackson CB, Farzan M, Chen B, Choe H. Mechanisms of SARS-CoV-2 entry into cells. Nature Rev Mol Cell Biol. 2022 Jan;23(1):3-20. https://www.nature.com/articles/s41580-021-00418-x
Shuster A, Pechalrieu D, Jackson CB, Abegg D, Choe H, Adibekian A. Clinical Antiviral Drug Arbidol Inhibits Infection by SARS-CoV-2 and Variants through Direct Binding to the Spike Protein. ACS Chem Biol. 2021 Nov 18:acschembio.1c00756. https://doi.org/10.1021/acschembio.1c00756
Guo Y, He W, Mou H, Zhang L, Chang J, Peng S, Ojha A, Tavora R, Parcells MS, Luo G, Li W, Zhong G, Choe H, Farzan M, Quinlan BD. An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines. mBio. 2021 May 11;12(3):e00930-21. https://doi.org/10.1128/mbio.00930-21
Choe H and Farzan M. How SARS-CoV-2 first adapted in humans. Science. 2021. Apr 30; 372(6541):466-467. https://www.science.org/doi/10.1126/science.abi4711
Mou H, Quinlan BD, Peng H, Liu G, Guo Y, Peng S, Zhang L, Davis-Gardner ME, Gardner MR, Crynen G, DeVaux LB, Voo X, Bailey CC, Alpert MD, Rader C, Gack MU, Choe H, Farzan M. Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2. PLoS Pathog. 2021 Apr; 17(4): e1009501. https://doi.org/10.1371/journal.ppat.1009501
Jackson CB, Zhang L, Farzan M, Choe H. Functional importance of the D614G mutation in the SARS-CoV-2 spike protein. Biochem Biophys Res Commun. 2021 Jan 29; 538:108-115. https://doi.org/10.1016/j.bbrc.2020.11.026
Ou T, Mou H, Zhang L,Ojha A, Choe H, Farzan M. Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2. PLoS Pathog. 2021 Jan;17(1):e1009212. https://doi.org/10.1371/journal.ppat.1009212
Zhang L, Jackson CB, M H, Ojha A, Peng H, Quinlan B, Rangarajan ES, Pan A, Vanderheiden A, Suthar MS, Li W, Izard T, Rader C, Farzan M*, Choe H*. SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity. Nature Commun. 2020 Nov 26;11(1): 6013. https://doi.org/10.1038/s41467-020-19808-4
Jackson CB, Richard AS, Ojha A, Conkright KA, Trimarchi JM, Bailey CC, Alpert MD, Kay MA, Farzan M, Choe H. AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery. Mol Ther Methods Clin Dev. 2020 Nov 17;19:496-506. https://doi.org/10.1016/j.omtm.2020.11.004
Zhang L, Richard AS, Jackson CB, Ojha A, Choe H. Phosphatidylethanolamine and phosphatidylserine synergize to enhance GAS6/AXL-mediated virus infection and efferocytosis. J. Virol. 2020 Dec 22;95(2):e02079-20. https://doi.org/10.1128/jvi.02079-20
Brell J, Berg V, Modak M, Puck A, Zlabinger G, Steinberger P, Chou J, Geha R, Öhler L, Yachie A, Choe H, Stöckl J. Transferrin receptor 1 is a cellular receptor for human heme-albumin. Commun Biol. 2020; 3: 621. https://doi.org/10.1038/s42003-020-01294-5
Laczko D, Hogan MJ, Toulmin SA, Hicks P, Lederer K, Gaudette BT, Castano D, Amanat F, Muramatsu H, Oguin III TH, Ojha A, Zhang L, Mu Z, Parks R, Manzoni TB, Roper B, Strohmeier S, Tombacz I, Arwood L, Nachbagauer R, Kariko K, Greenhouse Pessaint JL, Porto M, Putman-Taylor T, Strasbaugh A, Campbell T, Lin PJC, Tam YK, Sempowski GD, Farzan M, Choe H, Saunders KO, Haynes BF, Andersen H, Eisenlohr LC, Weissman D, Krammer F, Bates P, Allman D, Locci M, Pardi N. A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. Immunity 2020 Oct 13;53(4):724-732. https://doi.org/10.1016/j.immuni.2020.07.019
Shim BS, Kwon YC, Ricciardi MJ, Stone M, Otsuka Y, Berri F, Kwal JM, Magnani DM, Jackson CB, Richard AS, Norris P, Busch M, Curry CL, Farzan M, Watkins D, Choe H. Zika Virus-Immune Plasmas from Symptomatic and Asymptomatic Individuals Enhance Zika Pathogenesis in Adult and Pregnant Mice. mBio. 2019 Jul 2;10(4). pii: e00758-19. (PMCID: PMC6606798) https://doi.org/10.1128/mBio.00758-19
Reed AJ, Connelly RP, Williams A, Tran M, Shim BS, Choe H, Gerasimova YV. Label-Free Pathogen Detection by a Deoxyribozyme Cascade with Visual Signal Readout. Sens Actuators B Chem. 2019 Mar 1;282:945-951. (PMCID: PMC6713451) https://doi.org/10.1016/j.snb.2018.11.147
Otsuka Y, Schmitt K, Quinlan BD, Gardner MR, Alfant B, Reich A, Farzan M, Choe H. Diverse pathways of escape from all well-characterized VRC01-class broadly neutralizing HIV-1 antibodies. PLoS Pathog. 2018 Aug 20;14(8):e1007238. (PMCID: PMC6117093) https://doi.org/10.1371/journal.ppat.1007238
Ricciardi MJ, Magnani DM, Grifoni A, Kwon YC, Gutman MJ, Grubaugh ND, Gangavarapu K, Sharkey M, Silveira CGT, Bailey VK, Pedreño-Lopez N, Gonzalez-Nieto L, Maxwell HS, Domingues A, Martins MA, Pham J, Weiskopf D, Altman J, Kallas EG, Andersen KG, Stevenson M, Lichtenberger P, Choe H, Whitehead SS, Sette A, Watkins DI. Ontogeny of the B- and T-cell response in a primary Zika virus infection of a dengue-naïve individual during the 2016 outbreak in Miami, FL. PLoS Negl Trop Dis. 2017 Dec 21;11(12):e0006000. (PMCID: PMC29267278) https://doi.org/10.1371/journal.pntd.0006000
Richard AS, Shim BS, Kwon YC, Zhang R, Otsuka Y, Schmitt K, Berri F, Diamond MS, Choe H. AXL-dependent infection of human fetal endothelial cells distinguishes Zika virus from other pathogenic flaviviruses. Proc Natl Acad Sci U S A. 2017 Feb 21; 114(8): 2024-9. (PMCID: PMC28167751) https://doi.org/10.1073/pnas.1620558114
Thenin-Houssier S, de Vera IM, Pedro-Rosa L, Brady A, Richard A, Konnick B, Opp S, Buffone C, Fuhrmann J, Kota S, Billack B, Pietka-Ottlik M, Tellinghuisen T, Choe H, Spicer T, Scampavia L, Diaz-Griffero F, Kojetin DJ, Valente ST. Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2195-208. (PMCID: PMC4808204) https://doi.org/10.1128/AAC.02574-15
Huang WC, Abraham R, Shim BS, Choe H*, Page DT*. Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice. Sci Rep. 2016 Oct 7;6:34793. (PMCID: PMC5054421) *co-corresponding authors. https://doi.org/10.1038/srep34793
Richard AS, Zhang A, Park S, Farzan M, Zong M, Choe H. Virion-associated phosphatidylethanolamine promotes TIM1-mediated infection by Ebola, dengue and West Nile viruses. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47): 14682–7. (PMCID: PMC4664333) https://doi.org/10.1073/pnas.1508095112
Rathbun JY, Droniou ME, Damoiseaux R, Haworth KG, Henley JE, Exline CM, Choe H, Cannon PM. Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening. J Virol. 2015 Aug 15;89(16):8428-43. (PMCID: PMC4524252) https://doi.org/10.1128/JVI.00997-15
Zong M, Fofana I, Choe H. Human and host species transferrin receptor 1 use by North American arenaviruses. J Virol. 2014 Aug;88(16):9418-28. (PMCID: PMC4136298) https://doi.org/10.1128/JVI.01112-14
Demogines A, Abraham J, Choe H, Farzan M, Sawyer SL. Dual host-virus arms races shape an essential housekeeping protein. PLoS Biol. 2013;11(5):e1001571. (PMCID: PMC3665890) https://doi.org/10.1371/journal.pbio.1001571
Jemielity J, Wang JJ, Chan YK, Ahmed AA, Li W, Monahan S, Bu X, Farzan M, Freeman GJ, Umetsu DT, DeKruyff RJ, Choe H. TIM-family proteins promote infection of multiple enveloped viruses through virion-associated phosphatidylserine. PLos Pathog. 2013 Mar 28;9(3):e1003232. (PMCID: PMC3610696) https://doi.org/10.1371/journal.ppat.1003232
Helguera G, Jemielity S, Abraham J, Cordo SM, Martinez MG, Rodríguez JA, Bregni C, Wang JJ, Farzan M, Penichet ML, Candurra NA, Choe H. An antibody recognizing the apical domain of human transferrin receptor 1 efficiently inhibits the entry of all New World hemorrhagic fever arenaviruses. J Virol. 2012 Apr;86(7):4024-8. (PMCID: PMC3302512) https://doi.org/10.1128/JVI.06397-11
Kwong JA, Dorfman T, Quinlan BD, Chiang JJ, Ahmed AA, Choe H, Farzan M. A Tyrosine-Sulfated CCR5-Mimetic Peptide Promotes Conformational Transitions in the HIV-1 Envelope Glycoprotein. J Virol. 2011 Aug;85(15):7563-71. (PMCID: PMC365685) https://doi.org/10.1128/JVI.00630-11
Choe H, Jemielity S, Abraham J, Radoshitzky SR, Farzan M. Transferrin receptor 1 in the zoonosis and pathogenesis of New World hemorrhagic fever arenaviruses. Curr Opin Microbiol. 2011 Aug;14(4):476-82. Review. (PMCID: PMC3159852) https://doi.org/10.1016/j.mib.2011.07.014
Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011 Jan 6;7(1):e1001258. (PMCID: PMC2346733) https://doi.org/10.1371/journal.ppat.1001258
Abraham J, Corbett KD, Farzan M, Choe H, Harrison SC. Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 2010 Apr;17(4):438-44. (PMCID: PMC2920743) https://doi.org/10.1038/nsmb.1772
Choe H, Farzan M. Chapter 7. Tyrosine sulfation of HIV-1 coreceptors and other chemokine receptors. Methods Enzymol. 2009; 461:147-70. https://doi.org/10.1016/S0076-6879(09)05407-X
Abraham J, Kwong JA, Albariño CG, Lu JG, Radoshitzky SR, Salazar-Bravo J, Farzan M, Spiropoulou CF, Choe H. Host-species transferrin receptor 1 orthologs are cellular receptors for nonpathogenic New World clade B arenaviruses. PLoS Pathog. 2009 Apr;5(4):e1000358. (PMCID: PMC2658809) https://doi.org/10.1371/journal.ppat.1000358
Radoshitzky SR, Kuhn JH, Spiropoulou CF, Albariño CG, Nguyen DP, Salazar-Bravo J, Dorfman T, Lee AS, Wang E, Ross SR, Choe H, Farzan M. Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2664-9. (PMCID: PMC2268193) https://doi.org/10.1073/pnas.0709254105
Liu CC, Mack AV, Tsao ML, Mills JH, Lee HS, Choe H, Farzan M, Schultz PG, Smider VV. Protein evolution with an expanded genetic code. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17688-93. (PMCID: PMC2584696) https://doi.org/10.1073/pnas.0809543105
Radoshitzky SR, Abraham J, Spiropoulou CF, Kuhn JH, Nguyen D, Li W, Nagel J, Schmidt PJ, Nunberg JH, Andrews NC, Farzan M, Choe H. Transferrin receptor 1 is a cellular receptor for New World hemorrhagic fever arenaviruses. Nature 2007, Mar 1;446(7131):92-6. (PMCID: PMC2658809) https://doi.org/10.1038/nature05539
Choe H, Farzan M. Tyrosine sulfate trapped by amber. Nat Biotechnol. 2006 Nov;24(11):1361-2. https://www.nature.com/articles/nbt1106-1361
Huang IC, Bosch BJ, Li F, Li W, Lee KH, Ghiran S, Vasilieva N, Dermody TS, Harrison SC, Dormitzer PR, Farzan M, Rottier PM, Choe H. SARS Coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells. J Biol Chem. 2006 Feb;281(6):3198-3203. (PMCID: PMC1142572) https://doi.org/10.1074/jbc.M508381200
Li W, Greenough TC, Moore M, Vasilieva N, Somasundaran M, Sullivan JL, Farzan M, Choe H. Efficient replication of SARS coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2. J Virol. 2004 Oct;78(20):11429-33. (PMCID: PMC521845) https://doi.org/10.1128/JVI.78.20.11429-11433.2004
Moore M, Dorfman T, Li W, Wong SK, Coderre J, Vasilieva N, Greenough TC, Farzan M, Choe H. Retroviruses pseudotyped with the Severe Acute Respiratory Syndrome coronavirus spike protein efficiently infect cells expressing Angiotensin-Converting Enzyme 2. J Virol. 2004 Oct;78(19):10628-35. (PMCID: PMC516384) https://doi.org/10.1128/JVI.78.19.10628-10635.2004
Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY, Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt R, Choe H, Farzan M, Kwong PD. Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120. Proc Natl Acad Sci U S A. 2004 Mar;101(9):2706-11. (PMCID: PMC365685) https://doi.org/10.1073/pnas.0308527100
Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, Somasundaran M, Sullivan JL, Luzuriaga K, Greenough TC, Choe H*, Farzan M*. Angiotensin-converting Enzyme 2 is a Functional Receptor for the SARS coronavirus. Nature. 2003 Nov;426(6965): 450-4. *co-corresponding authors. https://doi.org/10.1038/nature02145
Choe H, Li W, Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson JE, Sodroski JG, Farzan M. Tyrosine Sulfation of Human Antibodies Contributes to Recognition of the CCR5 Binding Region of HIV-1 gp120. Cell. 2003 Jul;114(2): 161-70. https://doi.org/10.1016/S0092-8674(03)00508-7
Farzan M, Babcock GJ, Vasilieva N, Wright PL, Kiprilov E, Mirzabekov T, Choe H. The role of post-translational modifications of the CXCR4 amino-terminus in SDF-1 association and HIV-1 entry. J Biol Chem. 2002 Aug;277(33): 29484-9. https://doi.org/10.1074/jbc.M203361200
Farzan M, Chung S, Li W, Vasilieva N, Schnitzler CE, Marchione RJ, Gerard C, Gerard NP, Sodroski J, Choe H. Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region. J Biol Chem. 2002 Oct;277(43):40397-402. https://doi.org/10.1074/jbc.M206784200
Farzan M, Schnitzler CE, Vasilieva N, Leung D, Kuhn J, Gerard C, Gerard NP, Choe H. Sulfated tyrosines contribute to the formation of the C5a docking site of the human C5a anaphylatoxin receptor. J Exp Med. 2001 May;193(9):1059-66. https://doi.org/10.1084/jem.193.9.1059
Farzan M, Mirzakov T, Kolchinsky P, Wyatt R, Cayabyab M, Gerard NP, Gerard C, Sodroski J, Choe H. Tyrosine Sulfation of Amino Terminus of CCR5 facilitates HIV-1 Entry. Cell. 1999 Mar;96(5):667-76. https://doi.org/10.1016/S0092-8674(00)80577-2
Choe H. Chemokine receptors in HIV-1 and SIV infection. Arch Pharm Res. 1998 Dec;21(6):634-9. Review. https://doi.org/10.1007/BF02976749
Choe H, Farzan M, Konkel M, Marcon L, Cayabyab M, Gerard NP, Gerard C and Sodroski J. The Orphan seven-transmembrane segment receptor apj supports the entry of primary dual- and T-tropic HIV-1 Isolates. J Virol. 1998 Jul;72(7):6113-8. (PMCID: PMC110417) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC110417/
He J, Chen Y, Farzan M, Choe H, Ohagen A, Gartner S, Busciglio J, Yang X, Hofmann W, Newman W, Mackay CR, Sodroski J, Gabuzda D. CCR3 andCCR5 are co-receptors for HIV-1 infection of microglia. Nature. 1997 Feb;385(6617):645-9. https://doi.org/10.1038/385645a0
Farzan M, Choe H, Martin K, Marcon L, Hofmann W, Karlsson G, Sun Y, Barrett P, Marchand N, Sullivan N, Gerard NP, Gerard C, Sodroski J. Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection. J Exp Med. 1997 Aug;186(3):405-11. (PMCID: PMC2198994) https://doi.org/10.1084/jem.186.3.405
Wu L, Gerard NP, Wyatt R, Choe H, Parolin C, Ruffing N, Borsetti A, Cardoso AA, Desjardin E, Newman W, Gerard C, Sodroski J. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR5. Nature. 1996 Nov;384(6605):179-83. https://doi.org/10.1038/384179a0
Bleul CC, Farzan M, Choe H, Parolin C, Clark-Lewis I, Sodroski J, Springer TA. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 1996 Aug;382(6594):829-33. https://doi.org/10.1038/382829a0
Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard NP, Gerard C, Sodroski J. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 1996 Jun;85(7):1135-48. https://doi.org/10.1016/S0092-8674(00)81313-6