Lab Members | Overview
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Peter Nigrovic, MD Chief, Division of Immunology; Attending Physician, Rheumatology Program Professor of Pediatrics, Harvard Medical School
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Dr. Nigrovic is Chief of the Division of Immunology at Boston Children’s Hospital and Professor of Pediatrics at Harvard Medical School. Dr. Nigrovic received a B.A. in philosophy from Amherst College, including a year of study at Corpus Christi College, Oxford, followed by his medical degree at Harvard Medical School. He completed med/peds residency in the Harvard Combined Program and med/peds rheumatology fellowship at Boston Children’s Hospital and the Brigham and Women’s Hospital, where he founded the Nigrovic laboratory in 2010.
Dr. Nigrovic also directs the NIAMS-funded Joint Biology Consortium arthritis research infrastructure. He is Deputy Editor of Arthritis & Rheumatology and serves on the Scientific Advisory Board of the Arthritis National Research Foundation. He was founding co-chair of the pediatric rheumatology mentoring program AMIGO. He received mentoring awards from Harvard Medical School in 2014 and 2019, and was elected in 2018 to the American Society for Clinical Investigation (ASCI).
Lab Members
Title: Undergraduate student, Barnard College of Columbia University.
Summer student in 2019, joining lab as a research assistant in 2021.
Title: Instructor in Pediatrics
Lab member since 2015
Publications and awards
Chang M, Brown HJ, Collado-Hidalgo A, Arevalo JM, Galic Z, Symensma TL, Tanaka L, Deng H, Zack JA, Sun R, and Cole SW. beta-Adrenoreceptors reactivate Kaposi’s sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA. J Virol. 2005 Nov; 79(21):13538-47.
Hashimi ST*, Fulcher JA*, Chang MH, Gov L, Wang S, Lee B. MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation. Blood. 2009 Jul 9; 114(2):404-14.
Fulcher JA*, Chang MH*, Wang S, Almazan T, Hashimi ST, Eriksson AU, Wen X, Pang M, Baum LG, Singh RR, Lee B. Galectin-1 co-clusters CD43/CD45 on dendritic cells and induces cell activation and migration through Syk and PKC signaling. J Biol Chem. 2009 Sep 25; 284(39):256860-70.
Thiemann S, Man JK, Chang MH, Lee B, Baum LG. Galectin-1 regulates tissue exit of specific dendritic cell populations. J Biol Chem. 2015 Sep 11; 290(37):22662-77.
Cunin P, Penke LR, Thon HN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, et al. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 2; 127(5):1714-1724
Halyabar O, Chang MH, Schoettler ML, Schwartz MA, Baris EH, Benson LA, Biggs CM, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht KG, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Dedeoglu F, Degar BA, Hazen MM, Henderson LA. Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Pediatr Rheumatol Online J. 2019 Feb 14;17(1):7
Lee PY, Schulert GS, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Wactor A, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2019 2020 Feb;79(2):225-231.
Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Julé AM, Charbonnier LM, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprogramming of T cells in systemic juvenile idiopathic arthritis. JCI Insight. 2020 Mar 26;5(6).
Stoll M, Duck L, Chang MH, Colbert R, Nigrovic P, Thompson S, Elson C. Identification of Prevotella Oralis as a Possible Target Antigen in Children with Enthesitis related arthritis. Clinical Immunology. 2020 May 10; 216:108463
Lee PY, Day-Lewis M, Henderson LA, Friedman K, Lo J, Roberts JE, Lo MS, Platt CD, Chou J, Hoyt KJ, Baker AL, Banzon T, Chang MH, Cohen E, de Ferranti S, Dionne A, Habiballah S, Halyabar O, Hausmann JS, Hazen M, Janssen E, Meidan E, Nelson RW, Nguyen AA, Sundel RP, Dedeoglu F, Nigrovic PA, Newburger JW, Son MBF. Distinct clinical and immunological features of SARS-COV-2-induced multisystem inflammatory syndrome in children. J Clin Invest. 2020 Jul 23; doi:10.1172/JCI141113.
Roberts JE, Nigrovic PA, Lo MS*, Chang MH*. Weekly adalimumab, an effective alternative for refractory uveitis in children. J Clin Rheum. In press.
Halyabar O, Friedman KG, Sundel RP, Baker AL, Chang MH, Gould PW, Newburger JW, Son MBF. Cyclophosphamide use in treatment of refractory Kawasaki disease with coronary artery aneurysms. Pediatric Rheumatology. In press.
Chang MH and Nigrovic PA. Antibody-dependent and -independent mechanisms of inflammatory arthritis. JCI Insight. 2019 Mar 7;4(5)
Lovejoy Resident Research Award, Boston Children’s Hospital, 2014 ($5,000)
American College of Rheumatology Resident Research Preceptorship, 2015 ($15,000)
American College of Rheumatology Pediatric Research Award, 2016
Pediatric Rheumatology Symposium Abstract Award , 2017
Rheumatology Research Foundation Scientist Development Award, 2018 ($225,000)
NIH K12 Institutional Career Development award 5K12HD052896-13, 2019-2021 ($250,000)
Title: Instructor in Medicine, Harvard Medical School
Lab member since 2013
Publications and awards
Cunin P, Nigrovic PA. Megakaryocyte emperipolesis: a new frontier in cell-in-cell interaction. [review] Platelets. 2019 Nov 21:1-7.
Lee PY*, Nelson-Maney N, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703.
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.
Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman R, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of beta2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Advances 2019 Feb 12;3(3):256-267.
Cunin P, Nigrovic PA. Megakaryocytes as immune cells. [review] J Leuk Biol 2019 Jun;105(6):1111-1121.
Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-88.
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood 2017 Nov 9;130(19):2092-2100.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.
Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest 2017;127:1714-1724.
Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.
Dellinger AL, Cunin P, Lee D, Kung AL, Brooks DB, Zhou Z, Nigrovic PA, Kepley CL. Inhibition of inflammatory arthritis using fullerene nanomaterials. PLoS One. 2015 Apr 16;10(4):e0126290. doi: 10.1371/journal.pone.0126290. eCollection 2015.
Society for Leukocyte Biology Travel Prize, Verona, Italy, 2016
Outstanding Abstract Presentation Award, Gordon Research Seminar, Barga, Italy, 2017
Arthritis National Research Foundation research grant 2018 and 2019 ($200,000)
Gilead Sciences Research Scholars Program in Rheumatology, 2020-22 ($150,000)
Title: Postdoctoral Fellow
Lab member since 2019
Dr. Darbousset completed her Ph.D. in Professor Francoise Dignat-George’s lab (INSERM-UMR 1076) under the supervision of Professor Christophe Dubois at the University of Aix-Marseille in France in December 2013. She was a postdoctoral fellow from 2014 to 2018 in Professor Shaun Jackson’s laboratory, first at the Australian Centre For Blood Diseases (ACBD) and the at the Heart Research Institute (HRI) and the Charles Perkins Centre (CPC), affiliated with Sydney University, Australia.
Publications and awards
Darbousset R*., Schoenwaelder S*., Crammer S*., et al. 14-3-3ζ regulates the mitochondrial repiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function. 2016, Nature Communications, 7:12862 (*) co-first authors.
Darbousset, R.; Delierneux, C.; Mezouar, S.; et al. P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice. 2014, Blood, 124(16): 2575-2585.
Darbousset, R.; Thomas, GM..; Mezouar, S.; et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. 2012, Blood, 120(10): 2133-2143.
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)
Title: Heidelberg University Medical Student
Lab member since 2019 studying megakaryocyte emperipolesis and neutrophil biology.
Publications and awards
German National Academic Foundation since 2018
Boehringer Ingelheim Fonds MD Fellowship (2019 – 2020; €21,900)
Title: Postdoctoral Fellow
Lab member since 2019
Dr. Huang is an attending physician in the Department of Rheumatology and Immunology at Guangdong Second Provincial General Hospital, Guangdong Emergency Medical Center, affiliated hospital of Southern Medical University, Guangzhou, China. Dr. Huang joined the laboratory in 2019 as a postdoctoral fellow under the supervision of Dr. Peter Nigrovic and Dr. Pui Lee to study mTOR biology, systemic JIA, DADA2, and gout.
Publications and awards
Lee PY, Huang Z, Hershfield MS, Nigrovic PA. Analysis of peripheral blood ADA1 and ADA2 levels in children and adults. Ann Rheum Dis 2020 Feb 13. pii: annrheumdis-2020-217055.
Lee PY*, Kellner ES, Huang Y, Furutani E, Huang Z, Bainter W, Alosaimi MF, Stafstrom K, Platt CD, Stauber T, Raz S, Tirosh I, Weiss A, Jordan MB, Krupski C, Eleftheriou D, Brogan P, Sobh A, Baz Z, Lefranc G, Kilic SS, El-Owaidy R, Pimpale P, Khubhandani R, Chambers EC, Chou J, Geha RS, Nigrovic PA+, Zhou Q+. Genotype and functional correlates of disease phenotype in Deficiency of Adenosine Deaminase 2 (DADA2). J Allerg Clin Immunol 2020 Jan 13. pii: S0091-6749(20)30030-0. (+ co-senior author)
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)
Title: Postdoctoral Fellow
Lab member since 2019
Dr. Elham Karimizadeh joined the Nigrovic Lab as a postdoctoral research fellow in September 2019. Before joining the lab, she completed a postdoc in the Rheumatology Research Center, Tehran University of Medical Sciences. She received her Ph.D. in Cellular and Molecular Biology from the University of Tehran. She investigates neutrophil biology in autoimmune and rheumatic diseases.
Title: Postdoctoral Fellow
Lab member since 2018 studying non-coding genetic variants in arthritis
Dr. Taehyeung Kim is a postdoctoral research fellow working on the identification of novel mechanisms in autoimmunity mediated by non-coding genetic variants. Dr. Kim received his Bachelor’s degree in Biochemistry from Chungnam National University, South Korea, followed by his Ph.D. degree at Korea Advanced Institute of Science and Technology.
Awards
Joint Biology Consortium Microgrant, NIH P30AR070253, 2019 ($5,000)
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)
Lab member since 2021
Daphne completed her PhD in megakaryocyte biology with Dr. Craig Morell in 2020 (Rochester) and joined the Nigrovic lab in 2021 to study the biology of megakaryocytes as immune cells.
Title: Heidelberg University Medical Student
Lab member since 2020 studying neutrophil biology and Lyme disease diagnostics.
Publications and awards
German National Academic Foundation since 2016
Boehringer Ingelheim Fonds MD Fellowship 2020-2021 (€22.800)
MIT Advanced Study Program (2020-21)
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)
Title: Heidelberg University Medical Student
Lab member since 2020 studying T regulatory cell dysfunction.
Publications and awards
PROMOS scholarship from the German Academic Exchanges Service (2020, €1,150)
Title: Program Coordinator of the Joint Biology Consortium
Anu is originally from Nepal and received her Bachelor’s degree in Computer Information Systems at Bellevue University, Nebraska. She joined the lab as Program Coordinator of the JBC in July 2019.
Title: Research Assistant I
Lab member since 2021
Marc completed a Bachelor’s degree in Biology at Davidson College and joined the Nigrovic lab in 2021 as a technician to assist with studies of neutrophils and related biology.
Title: Research Assistant II
Lab member since 2018
Alex manages the laboratory and assists in research on T resident memory and T effector cells cells in arthritis and uveitis.
Publications and awards
Lee PY, Schulert GS, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Wactor A, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis. Ann Rheum Dis. 2020 Feb;79(2):225-231. doi: 10.1136/annrheumdis-2019-216030. Epub 2019 Nov 9. PubMed PMID: 31707357.
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife. 2019 May 1;8. pii: e44031. doi: 10.7554/eLife.44031. PubMed PMID: 31042146; PubMed Central PMCID: PMC6494422.
Title: Postdoctoral Fellow
Lab member since 2018 studying non-coding genetic variants in arthritis and lupus
Dr. Qiang Wang is a postdoctoral research fellow working on the identification of new genetic mechanisms in systemic lupus erythematosus and inflammatory arthritis. Dr. Wang received his Bachelor’s degree in Veterinary Medicine from Jilin University, China, followed by his Ph.D. degree at Tufts University.
Publications and awards
Joint Biology Consortium Microgrant, NIH P30AR070253, 2020 ($5,000)
Title: Research Assistant I
Lab member since 2019
Brian Wauford graduated from Bates College in 2019 and he assists in research on T cells in arthritis and in the biology of IL-1-mediated inflammation.
Former Lab Members
Title: Research Assistant
Lab member 2018-2020
2017 BRI Summer Research Intern from Bates College
Publications and awards
Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.
Brigham Research Institute Research Staff Travel Award 2019
Title: Research Assistant
Lab member 2012-2016
Publications and awards
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.
Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.
Accepted to the University of Massachusetts Medical School, 2016.
Title: Postdoctoral Fellow
Lab member 2015-2017
Publications and awards
Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.
Bai M, Pang X, Lou J, Zhou Q, Zhang K, Ma J, Li J, Sun F, Hsu VW. Mechanistic insights into regulated cargo binding by ACAP1 protein. J Biol Chem. 2012 Aug 17;287(34):28675-85. doi: 10.1074/jbc.M112.378810. Epub 2012 May 29.
Hsu VW, Bai M, Li J. Getting active: protein sorting in endocytic recycling. Nat Rev Mol Cell Biol. 2012 Apr 13;13(5):323-8. doi: 10.1038/nrm3332. Review.
Bai M, Gad H, Turacchio G, Cocucci E, Yang JS, Li J, Beznoussenko GV, Nie Z, Luo R, Fu L, Collawn JF, Kirchhausen T, Luini A, Hsu VW. ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol. 2011 May;13(5):559-67. doi: 10.1038/ncb2221. Epub 2011 Apr 17.
Li J, Peters PJ, Bai M, Dai J, Bos E, Kirchhausen T, Kandror KV, Hsu VW. An ACAP1-containing clathrin coat complex for endocytic recycling. J Cell Biol. 2007 Jul 30;178(3):453-64.
Title: Duke University Medical Student
Lab member 2017-2019
Publications and awards
Rheumatology Research Foundation Medical and Graduate Student Preceptorship entitled “Analyzing transitional care models in chronic illness: CAPRI.”
Title: Research Trainee/Intern
Lab member 2016-2017
Publications and awards
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.
Title: Harvard Masters in Immunology student
Lab member 2017-2018
Publications and awards
Masters student in Nigrovic laboratory to study experimental genetics.
Title: Summer student 2019
Title: Research Assistant
Lab member 2018
Maya contributed to research on resident memory T cells. Maya is from Wisconsin and graduated from Harvard College.
Title: Postdoctoral Fellow
Lab member 2010-2014
Publications and awards
Ercan A, Cui J, Hazen MM, Batliwalla F, Royle L, Rudd PM, Coblyn JS, Shadick N, Weinblatt ME, Gregersen P, Lee DM, Nigrovic PA. Hypogalactosylation of serum N-glycans fails to predict clinical response to methotrexate and TNF inhibition in rheumatoid arthritis. Arthritis Res Ther. 2012 Mar 5; 14(2):R43.
Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.
Adamczyk B, Struwe WB, Ercan A, Nigrovic PA, Rudd PM. Characterization of fibrinogen glycosylation and its importance for serum/plasma N-glycome analysis. J Proteome Res. 2013 Jan 4;12(1):444-54.
Ackerman ME, Crispin M, Yu X, Baruah K, Boesch AW, Harvey DJ, Dugast AS, Heizen EL, Ercan A, Choi I, Streeck H, Nigrovic PA, Bailey-Kellogg C, Scanlan C, Alter G. Natural variation in Fc glycosylation of HIV-specific antibodies impacts antiviral activity. J Clin Invest. 2013 May 1;123(5):2183-92.
Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.
Ercan A, Kohrt W, Cui J, Deane KD, Pezer M, Yu EW, Hausmann JS, Campbell H, Kaiser UB, Rudd PM, Lauc G, Wilson JF, Finkelstein JS, and Nigrovic PA. Estrogens regulate glycosylation of immunoglobulin G in women and men. JCI Insight 2017;2:e89703.
Best Clinical/Translational Abstract Award (BWH Biomedical Research Institute, 2010)
Research Grant, Arthritis National Research Foundation, 2011-2013
Kelly Prize in JIA Research, ANRF, 2011 and 2012 ($150,000)
Research Grant, NIH Building Interdisciplinary Careers in Women’s Health Research (BIRCWH), 2012-2014 ($300,000)
BWH Best Musculoskeletal Research Paper prize 2012
Instructor in Medicine, Harvard Medical School
Assistant Professor of Medicine, Harvard Medical School
2018 Ambassador of the American College of Rheumatology
2019 Visiting Professor of Rheumatology, Guangdong Second Provincial Hospital, Guangzhou China
2019 Socio Correspondiente, Chilean Society for Rheumatology
2019 Harvard Program Award for Culture of Excellence in Mentoring
Title: Research Assistant
Lab member 2010-2012
Publications and awards
Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.
Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.
Accepted to Medical School, 2012.
Title: Summer student 2019
Title: Assistenzarzt, Universitätsklinik Heidelberg, Germany
Lab member since 2016
Publications and awards
Grieshaber-Bouyer R, Kämmerer T, Rosshirt N, Nees TA, Koniezke P, Tripel E, Schiltenwolf M, Kirsch J, Hagmann S, Moradi B. Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis. J Clin Med. 2019 Oct 5;8(10). pii: E1631.
Grieshaber-Bouyer R, Nigrovic PA. Neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease. Front. Immunol. 2019 Mar 4;10:346.
Grieshaber-Bouyer R, Nigrovic PA. Maestro endothelium conducts the neutrophils. Blood 2018;132(17):1734-1735.
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017;130(19):2092-2100, doi: https://doi.org/10.1182/blood-2017-03-768507
Grieshaber-Bouyer R and Gerber C. Arthroscopic Repair of Recurrent Posterior Shoulder Subluxation after Total Shoulder Arthroplasty. JBJS Case Connect. 2017;7:e71. doi: https://doi.org/10.2106/JBJS.CC.17.00048
Boehringer Ingelheim Fonds MD Fellowship (2016–2017; €19,200)
German National Academic Foundation (2012–2019)
Title: Postdoctoral Fellow
Lab member 2016-2018
Publications and awards
Halyabar O, Chang MC, Schoettler M, Schwartz MA, Benson L, Biggs CM, Dedeoglu F, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht K, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Degar BA, Hazen MM, Henderson LA. Calm in the Midst of Cytokine Storm: A Collaborative Approach to the Diagnosis and Treatment of Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. Pediatric Rheumatology 2019 Feb 14;17(1):7.
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.
Joint Biology Consortium Microgrant (2017, $5,000)
Title: Assistant Professor of Pediatrics, Harvard Medical School
Lab member/affiliate since 2010
Publications and awards
Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprograming of T cells in systemic juvenile idiopathic arthritis. JCI Insight 2020 Mar 26;5(6). pii: 132508.
Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.
Hou L, Balzaroloc M, Rao DA, Yuki K, Cooley J, Henderson LA, Jonsson AH, Kaisermani D, Gorman MP, Nigrovic PA, Bird PI, Becher B, Remold-O’Donnell E. SerpinB1 controls encephalitogenic T helper cells in neuroinflammation. Proc Nat Acad Sci USA 2019 Oct 8;116(41):20635-20643.
Halyabar O, Chang MC, Schoettler M, Schwartz MA, Benson L, Biggs CM, Dedeoglu F, Gorman M, Lehmann L, Lo MS, Nigrovic PA, Platt CD, Priebe GP, Rowe J, Sundel RP, Surana NK, Weinacht K, Mann A, Yuen JC, Meleedy-Rey P, Starmer A, Banerjee T, Degar BA, Hazen MM, Henderson LA. Calm in the Midst of Cytokine Storm: A Collaborative Approach to the Diagnosis and Treatment of Hemophagocytic Lymphohistiocytosis and Macrophage Activation Syndrome. Pediatric Rheumatology 2019 Feb 14;17(1):7.
Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka C, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivaskiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S and Brenner MB. Pathologically expanded ‘peripheral’ B cell-helper T cells in rheumatoid arthritis. Nature 2017 Feb 1;542(7639):110-114.
Henderson LA, Volpi S, Frugoni F, Janssen E, Kim S, Sundel RP, Dedeoglu F, Lo MS, Hazen MM, Son MB, Mathieu R, Zurakowski D, Yu N, Lebedeva T, Fuhlbrigge RC, Walter JE, Lee YN, Nigrovic PA, Notarangelo LD. Next Generation Sequencing Reveals Restriction and Clonotypic Expansion of Regulatory T Cells in Juvenile Idiopathic Arthritis. Arthritis Rheumatol. 2016 Jul;68(7):1758-68.
Ercan A, Barnes MG, Hazen M, Tory H, Henderson L, Dedeoglu F, Fuhlbrigge RC, Grom A, Holm Henderson LA, Loring SH, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. J Rheumatol. 2013 Mar; 40(3):273-81.
IA, Kellogg M, Kim S, Adamczyk B, Rudd PM, Son MB, Sundel RP, Foell D, Glass DN, Thompson SD, Nigrovic PA. Multiple juvenile idiopathic arthritis subtypes demonstrate pro-inflammatory IgG glycosylation. Arthritis Rheum. 2012 Sep; 64(9):3025-33.
Promotion to Instructor in Pediatrics, 2015
Rheumatology Research Foundation Scientist Development Award, 2014-2016 ($125,000)
Rheumatology Research Foundation Investigator Award, 2016-18 ($375,000)
NIAMS K08 AR073339 The Reprogramming of Regulatory T cells to a Th17 Phenotype in Systemic Juvenile Idiopathic Arthritis, 2018-2023 ($525,000)
Boston Children’s Hospital Faculty Career Development Fellowship Award, 2018-2020 ($100,000)
Laboratory Principal Investigator, Boston Children’s Hospital, 2019
Title: Research Specialist
Lab member since 2018
Publications and awards
Lee PY, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.
Lee PY, Kellner ES, Huang Y, Furutani E, Bainter W, Alosaimi MF, Stafstrom K, Platt CD, Stauber T, Raz S, Tirosh I, Weiss A, Jordan MB, Krupski C, Eleftheriou D, Brogan P, Sobh A, Baz Z, Lefranc G, Kilic SS, El-Owaidy R, Pimpale P, Khubhandani R, Chambers EC, Chou J, Geha RS, Nigrovic PA, Zhou Q. Genotype and functional correlates of disease phenotype in Deficiency of Adenosine Deaminase 2 (DADA2). J Allerg Clin Immunol 2020 Jan 13. pii: S0091-6749(20)30030-0.
Pui Y. Lee, Yuelong Huang, Qing Zhou, Oskar Schnappauf, Michael S. Hershfield, Ying Li, Nancy J. Ganson, Natalia Sampaio Moura, Ottavia M. Delmonte, Scellig S. Stone, Michael Rivkin, Sung-Yun Pai, Todd Lyons, Robert P. Sundel, Victor W. Hsu, Luigi D. Notarangelo, Ivona Aksentijevich, Peter A. Nigrovic. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. The Journal of Allergy and Clinical Immunology. PMID 29936104 DOI: 10.1016/j.jaci.2018.05.038.
Title: Coordinator
Lab member 2016-2019
Former member of Nigrovic laboratory responsible for coordinating the development of NIAMS P30-funded Joint Biology Consortium.
Title: Postdoctoral Fellow
Lab member 2010
Publications and awards
Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.
Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.
Title: Harvard Medical School, Masters of Medical Sciences in Immunology
Lab member since 2019 studying non-coding genetic variants in arthritis
Former member of Nigrovic laboratory responsible for coordinating the development of NIAMS P30-funded Joint Biology Consortium.
Title: Instructor in Pediatrics
Lab member/affiliate since 2012
Publications and awards
Henderson LA, Hoyt KJ, Lee PY, Rao DA, Jonsson AH, Nguyen JP, Rutherford K, Case S, Chang MH, Cohen EM, Dedeoglu F, Fuhlbrigge RC, Halyabar O, Hazen MM, Janssen E, Kim S, Lo J, Lo MS, Meidan E, Son MBF, Sundel RP, Stoll ML, Nusbaum C, Lederer JA, Chatila TA, Nigrovic PA. Th17 reprograming of T cells in systemic juvenile idiopathic arthritis. JCI Insight 2020 Mar 26;5(6). pii: 132508.
Lee PY*, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA*. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.
Lee PY*, Huang Z, Hershfield MS, Nigrovic PA. Analysis of peripheral blood ADA1 and ADA2 levels in children and adults. Ann Rheum Dis 2020 Feb 13. pii: annrheumdis-2020-217055.
Lee PY*, Kellner ES, Huang Y, Furutani E, Huang Z, Bainter W, Alosaimi MF, Stafstrom K, Platt CD, Stauber T, Raz S, Tirosh I, Weiss A, Jordan MB, Krupski C, Eleftheriou D, Brogan P, Sobh A, Baz Z, Lefranc G, Kilic SS, El-Owaidy R, Pimpale P, Khubhandani R, Chambers EC, Chou J, Geha RS, Nigrovic PA+, Zhou Q+. Genotype and functional correlates of disease phenotype in Deficiency of Adenosine Deaminase 2 (DADA2). J Allerg Clin Immunol 2020 Jan 13. pii: S0091-6749(20)30030-0. (+ co-senior author)
Lee PY*, Schulert G, Canna SW, Huang Y, Sundel J, Li Y, Hoyt KJ, Blaustein RB, Do T, Halyabar O, Chang MH, Dedeoglu F, Case SM, Meidan E, Lo MS, Sundel RP, Richardson ET, Newburger JW, Hershfield MS, Son MB, Henderson LA, Nigrovic PA*. Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic JIA. Ann Rheum Dis 2020 Feb;79(2):225-231.
Lee PY†*, Nelson-Maney N†, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703. († co-first authors, * co-corresponding authors)
Han S, Zhuang H, Lee PY, Li M, Yang L, Nigrovic PA, Reeves W. Differential responsiveness of monocyte and macrophage subsets to interferon. Arthr Rheum 2020 Jan;72(1):100-113.
Urso K, Caetano-Lopes J, Lee PY, Yan J, Henke K, Sury M, Liu H, Zgoda M, Jacome-Galarza C, Nigrovic PA, Duryea J, Harris MP, Charles JF. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 2019 Jun 5;127:104-113.
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.
Cunin P, Lee PY, Kim E, Schmider AB, Cloutier N, Pare A, Gunzer M, Soberman R, Lacroix S, Boilard E, Lefort CT, Nigrovic PA. Differential attenuation of beta2 integrin-dependent and -independent neutrophil migration by Ly6G ligation. Blood Advances 2019 Feb 12;3(3):256-267.
Lee PY, Huang Y, Zhou Q, Schnappauf O, Hershfield MS, Li Y, Ganson NJ, Sampaio Moura N, Delmonte OM, Stone SS, Rivkin M, Pai S-Y, Lyons T, Sundel RP, Hsu VW, Notarangelo LD, Aksentijevich I, Nigrovic PA. Disrupted N-linked glycosylation as a disease mechanism in deficiency of ADA2. J Allerg Clin Immunol 2018;142:1363-1365.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11).
Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology [review]. J Leukoc Biol. 2013 Oct;94(4):585-94.
Lovejoy Resident Research Award, 6/2012 ($6,000)
Lovejoy Resident Research Award, 11/2012 ($5,000)
ACR Resident Research Preceptorship, 2012 ($15,000)
Boston Children’s Medical Staff Organization House Officer Development Award for Empirical Research ($5,000)
Boston Children’s Hospital Alumni Travel Award ($1,000)
Tobé and Stephen E. Malawista Award of the Rheumatology Research Foundation, 2014
Rheumatology Research Foundation Scientist Development Award, 2015-2017 ($125,000)
Marshall J. Schiff, MD Memorial Fellow Research Award, 2015
ACR Distinguished Fellow Award, 2016
Promotion to Instructor in Pediatrics, 2016
Rheumatology Research Foundation Investigator Award, 2017-19 ($375,000)
NIAMS K08 AR074562 Metabolic control of monocyte development and function by amino acids, 2019-2024 ($525,000)
Promotion to Assistant Professor of Pediatrics, Harvard Medical School, 2019
Laboratory Principal Investigator, Boston Children’s Hospital, 2020
Title: Postdoctoral Fellow
Lab member 2015-2019
Publications and awards
Lee PY†*, Nelson-Maney N†, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703. († co-first authors, * co-corresponding authors)
Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.
Joint Biology Consortium Microgrant (2017, $5,000)
Pediatric Rheumatology Symposium Abstract Award, 2017
Marie Skłodowska-Curie Actions Individual Fellowship from the European Commission, 2019
Title: Instructor of Medicine
Lab member 2013-2018
Publications and awards
Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.
Promotion to Instructor in Medicine, Harvard Medical School, 2014
Kelly Prize in JIA Research, Arthritis National Research Foundation, 2015 and 2016
Research Grant, Arthritis National Research Foundation, 2015-2017 ($200,000)
Research Grant, National Multiple Sclerosis Society ($50,000)
NIH NINDS R21, 2016 ($275,000)
NIH NIAMS R21 ($275,000)
Title: 2017 and 2018 Summer Research Student from Brandeis University
Title: Postdoctoral Fellow
Lab member since 2016
Nigrovic PA, Martínez-Bonet M, Thompson SD. Implications of JIA genetic risk variants for disease pathogenesis and classification. [review] Current Opin Rheumatol 2019 Sept;31:401–410
Westra H-J*, Martínez-Bonet M*, Onengut S, Lee A, Luo Y, Das S, Teslovich N, Worthington J, Martin J, Huizinga T, Klareskog L, Rantapaa-Dahlqvist Sm Chen W-M, Quinlan A, Todd J, Eyre S, Nigrovic PA, Gregersen PK, Rich SS, Raychaudhuri S. Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes. Nature Genetics 2018;50:1366-1374. (Martínez-Bonet M, co-first author)
Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.
Martínez-Bonet, M., González-Serna, A., Clemente, M. I., Morón-López, S., Díaz, L., Navarro, M., et al. (2017). Relationship between CCR5(WT/Δ32) heterozygosity and HIV-1 reservoir size in adolescents and young adults with perinatally acquired HIV-1 infection. Clinical Microbiology and Infection, 23(5), 318-324.
Martínez-Bonet M, Palladino C, Briz V, Rudolph JM, Fackler OT, Relloso M, et al. (2015) A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities. PLoS ONE 10(12): e0145239. https://doi.org/10.1371/journal.pone.0145239.
Martínez-Bonet, M., Isabel Clemente, M., Jesús Serramía, M., Muñoz, E., Moreno, S., & Ángeles Muñoz-Fernández, M. (2015). Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1. Scientific Reports, 5, 16445. http://doi.org/10.1038/srep16445.
Martínez-Bonet, M., Puertas, M. C., Fortuny, C., Ouchi, D., Mellado, M. J., Rojo, P., … Martinez-Picado, J. (2015). Establishment and Replenishment of the Viral Reservoir in Perinatally HIV-1-infected Children Initiating Very Early Antiretroviral Therapy. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 61(7), 1169–1178. http://doi.org/10.1093/cid/civ456
Sara Borrell Fellowship funded by the Instituto de Salud Carlos III, 2019
Title: Research Assistant
Lab member 2014-2016
2017 summer research student
Publications and awards
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.
Accepted to New York Medical College, 2016
Title: Research Assistant
Lab member 2016-2018
Lee PY†*, Nelson-Maney N†, Huang Y, Levescot A, Wang Q, Wei K, Cunin P, Li Y, Lederer JA, Zhuang H, Han S, Kim EY, Reeves WH, Nigrovic PA.* High-dimensional analysis reveals a pathogenic role of inflammatory monocytes in experimental diffuse alveolar hemorrhage. JCI Insight 2019 Aug 8;4(15). pii: 129703. († co-first authors, * co-corresponding authors)
Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Nelson-Maney N, Morris A, Guo L, Weyrich AS, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. eLife 2019;8:e44031.
Lee PY, Sykes DB, Ameri S, Kalaitzidis D, Charles JF, Nelson-Maney N, Wei K, Cunin P, Morris A, Cardona AE, Root DE, Scadden DT, Nigrovic PA. The metabolic regulator mTORC1 controls terminal myeloid differentiation. Sci Immunol. 2017 May 26;2(11). pii: eaam6641. doi: 10.1126/sciimmunol.aam6641.
Current M.D./Ph.D. student at the University of North Carolina, Chapel Hill.
Title: Postdoctoral Fellow
Lab member 2010-2012
Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura I, Ware J, Gurish M, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in antibody-mediated murine arthritis. J Clin Invest 2017 May 1;127(5):1714-1724.
Title: Research Assistant
Lab member 2010-2011
Kaieda S*, Wang JX*, Shnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.
Wang J, Bair A, King S, Shnayder R, Hsieh YF, Shieh C-C, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a beta 2 integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.
Cloutier N, Tan S, Boudreau LH, Cramb C, Subbaiah R, Lahey L, Albert A, Shnayder R, Gobezie R, Nigrovic PA, Farndale RW, Robinson WH, Brisson A, Lee DM, Boilard E. The exposure of autoantigens by microparticles underlies the formation of potent inflammatory components: the microparticle-associated immune complexes. EMBO Mol Med. 2013 Feb; 5(2):235-49.
Accepted to Mount Sinai Medical School, 2016.
Title: Instructor in Medicine
Lab member 2010-2014
Bai M*, Grieshaber-Bouyer R*, Wang JX, Schmider AB, Wilson ZS, Zeng L, Halyabar O, Godin MD, Nguyen HN, Levescot A, Cunin P, Lefort CT, Soberman RJ, Nigrovic PA. CD177 modulates human neutrophil migration through activation-mediated integrin and chemoreceptor regulation. Blood. 2017 Nov 9; 130(19): 2092–2100.
Wang J, Bair A, King S, Shnayder R, Hsieh YF, Shieh C-C, Soberman RJ, Fuhlbrigge RC, Nigrovic PA. Ly6G ligation blocks recruitment of neutrophils via a beta 2 integrin-dependent mechanism. Blood. 2012 Aug 16; 120(7):1489-98.
Kaieda S*, Wang JX*, Schnayder R, Fishgal N, Hei H, Lee RT, Stevens RL, Nigrovic PA. Interleukin-33 primes mast cells for activation by IgG immune complexes. PLOS ONE. 2012; 7(10):e47252.
Lee PY, Wang JX, Parisini E, Dascher CC, Nigrovic PA. Ly6 family proteins in neutrophil biology [review]. J Leukoc Biol. 2013 Oct;94(4):585-94.281-6.
Wang JX*, Kaieda S*, Ameri S, Fishgal N, Dellinger A, Kepley KL, Gurish MG, Nigrovic PA. The IL-33/ST2 axis promotes mast cell survival via BCLXL. Proc Nat Acad Sci USA 2014 Jul 15;111(28):10281-6.
Research Grant, Arthritis National Research Foundation (2013-2015)
Promotion to Instructor in Medicine, Harvard Medical School, 2014
Title: Research Assistant to Dr. Gang Li
Lab member 2016-2018
Li G*, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra H-J, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA*. High Throughput Identification of Non-Coding Functional SNPs via Type IIS Enzyme Restriction. Nature Genetics 2018 Aug;50(8):1180-1188.
Li G, Cunin P, Wu D, Diogo D, Yang Y, Okada Y, Plenge RM, Nigrovic PA. The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. PLOS Genetics 2016;12:e1006292.
Nigrovic Lab 2017