The Ploegh Laboratory is interested in molecular aspects of immune recognition . This pursuit is complemented by the development of new technologies. These include the application of enzymatic methods for site-specific labeling of proteins . We then …

Cheloha RW, Fisher FA, Woodham AW, Daley E, Suminski N, Gardella TJ, Ploegh HL. Improved GPCR ligands from nanobody tethering. Nat Comm. 2020 11: 2087. View abstract Rehm FBH, Harmand TJ, Yap K, Durek T, Craik DJ, Ploegh HL. Site-specific sequential …

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Optic nerve regeneration : Inflammation, oncomodulin, and transcriptional control The inability of neurons to regenerate axons within the CNS has devastating consequences for victims of stroke, spinal cord injury, and other CNS insults. Due to its …

Eye for Growth: New protein prompts optic nerve regrowth Video: Dr. Larry Benowitz discusses Optic Nerve Regeneration Axon Regeneration in the CNS: Insights from the Optic Nerve Vision restoration to optic nerve regeneration news-and-lectures In the News …

1. Identification of novel genes mutated in various rare diseases The goals of the project is to understand the genetic and molecular underpinnings of various orphan diseases include Ohtahara syndrome (a devastating seizure disorder), ROHHAD syndrome (a …

At Stanford University from 1971-1977, while working on his Ph.D. with Robert Schimke, Fred Alt developed a mammalian cell subtractive hybridization approach that ultimately allowed him to discover gene amplification and genomic instability in mammalian …

Both parents of newly diagnosed children as well as those diagnosed as adults have commented that it can be challenging to absorb and process all the information received during the initial diagnosis. Other individuals and families have contacted us …

We are happy to discuss what we do in detail or explain any concepts that remain unclear. If you or a member of your family has one of the disorders that we are studying and you have questions or comments, please contact us. If you are a physician or …

Muscle Anatomy and Genetics This section contains information about different muscle types, with emphasis on skeletal muscle. We will also go over the structure and function of muscle tissue. Finally, as muscle composition is determined by our genes, a …