Both axons (via growth cones) and blood vessels (via EC tip cells) sense the environment for positive and negative cues, thus determining where they end up. At least four ligands and their receptors, first identified as mediators of axon guidance, have subsequently been found to regulate angiogenesis as well (Klagsbrun & Eichmann 2005).
Growth Cones, EC Tip Cells
Ligands and Receptors
