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The "myopathies" is the name given to a group of neuromuscular disorders that affect skeletal muscle, causing generalized muscular weakness among other symptoms. Literally, the word myopathy means "disease of the muscle" (myo=muscle; Gr. pathos=disease). …
Diet, Motor Activity & Daily Activity Limitations in Individuals with SELENON ( SEPN1 ) - Related Myopathy J.M. Prystupa 1 , R. Alvarez 2 , C. A. Genetti 1 , E. Weller 3 , S. Liu 4 , E.C. Troiano 1 , B. Moghadaszadeh 1 & A.H. Beggs 1 1 Boston Children's …
Ryanodine Receptor 1 Related Myopathies (RYR1-RM) are a group of congenital muscle diseases related and characterized by the involvement of a mutation in the ryanodine receptor calcium channel embedded in the membrane of the sarcoplasmic reticulum (SR). …
The SELENON (formally SEPN1) Related Myopathies (SELENON-RM) are a group of rare congenital myopathies which alter an individual’s ability to synthesize Selenoprotein N Moghadaszadeh et al . 2001; Ferreiro et al . 2002; Castets et al . 2009; Lescure et …
Clinical trials are studies or experiments designed to assess the safety and efficacy of new interventions such as drugs, medical devices, or biologics. Such studies are an integral component of new product discovery and development that is required by …
Our lab group has expertise in the application of epidemiologic and statistical methods for clinical and outcomes research studies. We have experience in data management; qualitative and quantitative research design; longitudinal repeated measures data …
We are conducting an investigation of the effects of general anesthesia on infants’ brains that could help to improve clinical outcomes. General anesthetics are given to patients of all ages to block pain and awareness during surgery. Research has …
Given the widespread use of anticonvulsants in the pediatric chronic pain population and the absence of scientific data supporting their use, our group is conducting a randomized, double blind, two group parallel design in which a broad group of …
We use rat sciatic block and intravenous infusion models to assess efficacy, local, and systemic toxicities for NeoSTX, alone, and in combination with bupivacaine, with and without epinephrine. This data will support our ongoing human Phase 1 clinical …
April M. Craft, PhD Orthopaedic Research Laboratories Enders Research Building 2nd floor Boston Children's Hospital 320 Longwood Avenue Boston, MA 02115 contact-us Craft Lab | Contact Us Contact the Craft Lab at Boston Children's Hospital. … Contact …