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Lipid presentation and inflammatory disease In contrast to MHC proteins, CD1 molecules present lipid antigens to T lymphocytes. We study the role of CD1a on Langerhans cells in skin inflammation, using mouse models of contact dermatitis and psoriasis as …
List of publications Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation. Czechowicz A, Palchaudhuri R, Scheck A, Hu Y, Hoggatt J, Saez B, Pang WW, Mansour …
Regulation of gene expression is essential for development and function of all cells. The complex cooperation of transcription factors and their required chromatin accessibility is orchestrated by epigenetic histone modifications. While widely studied …
Open Post-Doc Position We are looking for a highly motivated, energetic and goal-oriented fellow to join the lab. Our lab is located at Joslin Diabetes Center. A new fellow would be co-mentored by myself and C. Ronald Kahn, combining the strengths of a …
Current projects include: Multi-omics analysis of intestinal adaptation following bariatric surgery models in rodents, including understanding how luminal factors drive these changes. Human Intestinal Organoid modeling of bariatric surgery. GI Omics …
2016 Epidural Steroid Injections for Radiculopathy and/or Back Pain in Children & Adolescents 2015 Anesthesia, Alpha Waves & the Developing Brain 2015 Immediate Rescue Designs in Pediatric Analgesic Trails 2015 Neosaxitoxin for Prolonged Local …
Principal Investigator Charles Berde, MD, PhD Sara Page Mayo Chair, Pediatric Pain Medicine Professor of Anaesthesia (Pediatrics), Harvard Medical School Dr. Berde is the Sara Page Mayo Chair in Pediatric Pain Medicine and Professor of Anaesthesia …
Cryolipolysis is a non-invasive, skin cooling treatment for local fat reduction that causes prolonged hypoesthesia over the treated area. This clinical study shows that cryolipolysis causes significant and prolonged decreases in mechanical and thermal …
6-month interns/co-ops in machine learning and image analysis: (BS, MS, PhD, postdoc levels), 2021 Open positions Four full-time research intern/co-op positions are open at the Image, Informatics, and Intelligence (I3) Lab at Boston Children’s Hospital …
Defining the Human Articular Cartilage Lineage Our lab has developed methods that enable us to reproducibly and efficiently generate two distinct cartilage lineages from human embryonic stem cells and induced pluripotent stem cells (collectively hPSCs). …