Publications & Awards | Overview
Note: List of publications from researchers at Boston Children’s Hospital who used the core facility.
2024
Taub DG, Jiang Q, Pietrafesa F, Su J, Carroll A, Greene C, Blanchard MR, Jain A, El-Rifai M, Callen A, Yager K, Chung C, He Z, Chen C, Woolf CJ. The secondary somatosensory cortex gates mechanical and heat sensitivity. Nat Commun. 2024 Feb 12;15(1):1289. doi: 10.1038/s41467-024-45729-7. PMID: 38346995; PMCID: PMC10861531.
2023
Winter CC, Jacobi A, Su J, Chung L, van Velthoven CTJ, Yao Z, Lee C, Zhang Z, Yu S, Gao K, Duque Salazar G, Kegeles E, Zhang Y, Tomihiro MC, Zhang Y, Yang Z, Zhu J, Tang J, Song X, Donahue RJ, Wang Q, McMillen D, Kunst M, Wang N, Smith KA, Romero GE, Frank MM, Krol A, Kawaguchi R, Geschwind DH, Feng G, Goodrich LV, Liu Y, Tasic B, Zeng H, He Z. A transcriptomic taxonomy of mouse brain-wide spinal projecting neurons. Nature. 2023 Dec;624(7991):403-414. doi: 10.1038/s41586-023-06817-8. Epub 2023 Dec 13. PMID: 38092914; PMCID: PMC10719099.
Grzelka K, Wilhelms H, Dodt S, Dreisow ML, Madara JC, Walker SJ, Wu C, Wang D, Lowell BB, Fenselau H. A synaptic amplifier of hunger for regaining body weight in the hypothalamus. Cell Metab. 2023 May 2;35(5):770-785.e5. doi: 10.1016/j.cmet.2023.03.002. Epub 2023 Mar 24. PMID: 36965483; PMCID: PMC10160008.
Liu A, Milner ES, Peng YR, Blume HA, Brown MC, Bryman GS, Emanuel AJ, Morquette P, Viet NM, Sanes JR, Gamlin PD, Do MTH. Encoding of environmental illumination by primate melanopsin neurons. Science. 2023 Jan 27;379(6630):376-381. doi: 10.1126/science.ade2024. Epub 2023 Jan 26. PMID: 36701440; PMCID: PMC10445534.
Lebek S, Chemello F, Caravia XM, Tan W, Li H, Chen K, Xu L, Liu N, Bassel-Duby R, Olson EN. Ablation of CaMKIIδ oxidation by CRISPR-Cas9 base editing as a therapy for cardiac disease. Science. 2023 Jan 13;379(6628):179-185. doi: 10.1126/science.ade1105. Epub 2023 Jan 12. PMID: 36634166.
2022
Caravia XM, Ramirez-Martinez A, Gan P, Wang F, McAnally JR, Xu L, Bassel-Duby R, Liu N, Olson EN. Loss of function of the nuclear envelope protein LEMD2 causes DNA damage-dependent cardiomyopathy. J Clin Invest. 2022 Nov 15;132(22):e158897. doi: 10.1172/JCI158897. PMID: 36377660; PMCID: PMC9663152.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. PMID: 36417486.
Chirila AM, Rankin G, Tseng SY, Emanuel AJ, Chavez-Martinez CL, Zhang D, Harvey CD, Ginty DD. Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain. Cell. 2022 Nov 23;185(24):4541-4559.e23. doi: 10.1016/j.cell.2022.10.012. Epub 2022 Nov 4. PMID: 36334588; PMCID: PMC9691598.
Wang Y, Leung VH, Zhang Y, Nudell VS, Loud M, Servin-Vences MR, Yang D, Wang K, Moya-Garzon MD, Li VL, Long JZ, Patapoutian A, Ye L. The role of somatosensory innervation of adipose tissues. Nature. 2022 Sep;609(7927):569-574. doi: 10.1038/s41586-022-05137-7. Epub 2022 Aug 31. PMID: 36045288; PMCID: PMC9477745.
Takatoh J, Prevosto V, Thompson PM, Lu J, Chung L, Harrahill A, Li S, Zhao S, He Z, Golomb D, Kleinfeld D, Wang F. The whisking oscillator circuit. Nature. 2022 Sep;609(7927):560-568. doi: 10.1038/s41586-022-05144-8. Epub 2022 Aug 31. PMID: 36045290.
Tseng SY, Chettih SN, Arlt C, Barroso-Luque R, Harvey CD. Shared and specialized coding across posterior cortical areas for dynamic navigation decisions. Neuron. 2022 Aug 3;110(15):2484-2502.e16. doi: 10.1016/j.neuron.2022.05.012. Epub 2022 Jun 8. PMID: 35679861; PMCID: PMC9357051.
Ran C, Boettcher JC, Kaye JA, Gallori CE, Liberles SD. A brainstem map for visceral sensations. Nature. 2022 Sep;609(7926):320-326. doi: 10.1038/s41586-022-05139-5. Epub 2022 Aug 31. Erratum in: Nature. 2022 Nov;611(7934):E6. PMID: 36045291; PMCID: PMC9452305.
Tian F, Cheng Y, Zhou S, Wang Q, Monavarfeshani A, Gao K, Jiang W, Kawaguchi R, Wang Q, Tang M, Donahue R, Meng H, Zhang Y, Jacobi A, Yan W, Yin J, Cai X, Yang Z, Hegarty S, Stanicka J, Dmitriev P, Taub D, Zhu J, Woolf CJ, Sanes JR, Geschwind DH, He Z. Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells. Neuron. 2022 Aug 17;110(16):2607-2624.e8. doi: 10.1016/j.neuron.2022.06.003. Epub 2022 Jun 28. Erratum in: Neuron. 2023 Feb 1;111(3):444. PMID: 35767995; PMCID: PMC9391318.
Jacobi A, Tran NM, Yan W, Benhar I, Tian F, Schaffer R, He Z, Sanes JR. Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells. Neuron. 2022 Aug 17;110(16):2625-2645.e7. doi: 10.1016/j.neuron.2022.06.002. Epub 2022 Jun 28. PMID: 35767994; PMCID: PMC9391321.
Zhang Y, Li H, Nishiyama T, McAnally JR, Sanchez-Ortiz E, Huang J, Mammen PPA, Bassel-Duby R, Olson EN. A humanized knockin mouse model of Duchenne muscular dystrophy and its correction by CRISPR-Cas9 therapeutic gene editing. Mol Ther Nucleic Acids. 2022 Aug 1;29:525-537. doi: 10.1016/j.omtn.2022.07.024. PMID: 36035749; PMCID: PMC9398917.
Zhang Y, Roy DS, Zhu Y, Chen Y, Aida T, Hou Y, Shen C, Lea NE, Schroeder ME, Skaggs KM, Sullivan HA, Fischer KB, Callaway EM, Wickersham IR, Dai J, Li XM, Lu Z, Feng G. Targeting thalamic circuits rescues motor and mood deficits in PD mice. Nature. 2022 Jul;607(7918):321-329. doi: 10.1038/s41586-022-04806-x. Epub 2022 Jun 8. PMID: 35676479; PMCID: PMC9403858.
Cheng Y, Yin Y, Zhang A, Bernstein AM, Kawaguchi R, Gao K, Potter K, Gilbert HY, Ao Y, Ou J, Fricano-Kugler CJ, Goldberg JL, He Z, Woolf CJ, Sofroniew MV, Benowitz LI, Geschwind DH. Transcription factor network analysis identifies REST/NRSF as an intrinsic regulator of CNS regeneration in mice. Nat Commun. 2022 Jul 29;13(1):4418. doi: 10.1038/s41467-022-31960-7. PMID: 35906210; PMCID: PMC9338053.
van Beelen ESA, van der Valk WH, Verhagen TO, de Groot JCMJ, Madison MA, Shadmanfar W, Hensen EF, Jansen JC, van Benthem PPG, Holt JR, Locher H. Efficient Viral Transduction in Fetal and Adult Human Inner Ear Explants with AAV9-PHP.B Vectors. Biomolecules. 2022 Jun 10;12(6):816. doi: 10.3390/biom12060816. PMID: 35740941; PMCID: PMC9221426.
Harbauer AB, Hees JT, Wanderoy S, Segura I, Gibbs W, Cheng Y, Ordonez M, Cai Z, Cartoni R, Ashrafi G, Wang C, Perocchi F, He Z, Schwarz TL. Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy. Neuron. 2022 May 4;110(9):1516-1531.e9. doi: 10.1016/j.neuron.2022.01.035. Epub 2022 Feb 24. PMID: 35216662; PMCID: PMC9081165.
Kim S, Wallace ML, El-Rifai M, Knudsen AR, Sabatini BL. Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system. Neuron. 2022 Apr 20;110(8):1371-1384.e7. doi: 10.1016/j.neuron.2022.01.007. Epub 2022 Feb 3. PMID: 35120627; PMCID: PMC9056948.
Karri DR, Zhang Y, Chemello F, Min YL, Huang J, Kim J, Mammen PPA, Xu L, Liu N, Bassel-Duby R, Olson EN. Long-term maintenance of dystrophin expression and resistance to injury of skeletal muscle in gene edited DMD mice. Mol Ther Nucleic Acids. 2022 Mar 8;28:154-167. doi: 10.1016/j.omtn.2022.03.004. PMID: 35402069; PMCID: PMC8956962.
Lutas A, Fernando K, Zhang SX, Sambangi A, Andermann ML. History-dependent dopamine release increases cAMP levels in most basal amygdala glutamatergic neurons to control learning. Cell Rep. 2022 Jan 25;38(4):110297. doi: 10.1016/j.celrep.2022.110297. PMID: 35081349; PMCID: PMC8867603.
Su Y, Barr J, Jaquish A, Xu J, Verheyden JM, Sun X. Identification of lung innervating sensory neurons and their target specificity. Am J Physiol Lung Cell Mol Physiol. 2022 Jan 1;322(1):L50-L63. doi: 10.1152/ajplung.00376.2021. Epub 2021 Nov 10. PMID: 34755535; PMCID: PMC8721910.
2021
Nurunisa Akyuz, K. Domenica Karavitaki, Bifeng Pan, Panos I. Tamvakologos, Kelly P. Brock, Yaqiao Li, Debora S. Marks, David P. Corey. Mechanical gating of the auditory transduction channel TMC1 involves the fourth and sixth transmembrane helices. bioRxiv 2021.12.30.474567; doi: 10.1101/2021.12.30.474567
Kim A, Knudsen JG, Madara JC, Benrick A, Hill TG, Abdul Kadir L, Kellard JA, Mellander L, Miranda C, Lin H, James T, Suba K, Spigelman AF, Wu Y, MacDonald PE, Wernstedt Asterholm I, Magnussen T, Christensen M, Vilsbøll T, Salem V, Knop FK, Rorsman P, Lowell BB, Briant LJ. Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. Elife. 2021 Nov 17;10:e72919. doi: 10.7554/eLife.72919. PMID: 34787082; PMCID: PMC8654374.
Lee J, Sabatini BL. Striatal indirect pathway mediates exploration via collicular competition. Nature. 2021 Nov;599(7886):645-649. doi: 10.1038/s41586-021-04055-4. Epub 2021 Nov 3. PMID: 34732888; PMCID: PMC10281058.
Melzer S, Newmark ER, Mizuno GO, Hyun M, Philson AC, Quiroli E, Righetti B, Gregory MR, Huang KW, Levasseur J, Tian L, Sabatini BL. Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories. Cell. 2021 Oct 28;184(22):5622-5634.e25. doi: 10.1016/j.cell.2021.09.013. Epub 2021 Oct 4. PMID: 34610277; PMCID: PMC8556345.
Lehnert BP, Santiago C, Huey EL, Emanuel AJ, Renauld S, Africawala N, Alkislar I, Zheng Y, Bai L, Koutsioumpa C, Hong JT, Magee AR, Harvey CD, Ginty DD. Mechanoreceptor synapses in the brainstem shape the central representation of touch. Cell. 2021 Oct 28;184(22):5608-5621.e18. doi: 10.1016/j.cell.2021.09.023. Epub 2021 Oct 11. PMID: 34637701; PMCID: PMC8556359.
Zhang SX, Lutas A, Yang S, Diaz A, Fluhr H, Nagel G, Gao S, Andermann ML. Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling. Nature. 2021 Sep;597(7875):245-249. doi: 10.1038/s41586-021-03845-0. Epub 2021 Aug 25. PMID: 34433964; PMCID: PMC8884112.
Suter TACS, Wang J, Meng H, He Z. Utilizing mouse optic nerve crush to examine CNS remyelination. STAR Protoc. 2021 Sep 9;2(3):100796. doi: 10.1016/j.xpro.2021.100796. PMID: 34786561; PMCID: PMC8579818.
Kim A, Madara JC, Wu C, Andermann ML, Lowell BB. Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality. Elife. 2021 Sep 29;10:e66609. doi: 10.7554/eLife.66609. PMID: 34585668; PMCID: PMC8601670.
Roy DS, Zhang Y, Aida T, Choi S, Chen Q, Hou Y, Lea NE, Skaggs KM, Quay JC, Liew M, Maisano H, Le V, Jones C, Xu J, Kong D, Sullivan HA, Saunders A, McCarroll SA, Wickersham IR, Feng G. Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models. Neuron. 2021 Aug 18;109(16):2590-2603.e13. doi: 10.1016/j.neuron.2021.06.005. Epub 2021 Jun 30. PMID: 34197733; PMCID: PMC8376805
Berrios J, Li C, Madara JC, Garfield AS, Steger JS, Krashes MJ, Lowell BB. Food cue regulation of AGRP hunger neurons guides learning. Nature. 2021 Jul;595(7869):695-700. doi: 10.1038/s41586-021-03729-3. Epub 2021 Jul 14. PMID: 34262177; PMCID: PMC8522184.
Tao J, Campbell JN, Tsai LT, Wu C, Liberles SD, Lowell BB. Highly selective brain-to-gut communication via genetically defined vagus neurons. Neuron. 2021 Jul 7;109(13):2106-2115.e4. doi: 10.1016/j.neuron.2021.05.004. Epub 2021 Jun 1. PMID: 34077742; PMCID: PMC8273126.
Takatoh J, Park JH, Lu J, Li S, Thompson PM, Han BX, Zhao S, Kleinfeld D, Friedman B, Wang F. Constructing an adult orofacial premotor atlas in Allen mouse CCF. Elife. 2021 Apr 27;10:e67291. doi: 10.7554/eLife.67291. PMID: 33904410; PMCID: PMC8137149.
Wu J, Solanes P, Nist-Lund C, Spataro S, Shubina-Oleinik O, Marcovich I, Goldberg H, Schneider BL, Holt JR. Single and Dual Vector Gene Therapy with AAV9-PHP.B Rescues Hearing in Tmc1 Mutant Mice. Mol Ther. 2021 Mar 3;29(3):973-988. doi: 10.1016/j.ymthe.2020.11.016. Epub 2020 Nov 17. PMID: 33212302; PMCID: PMC7934577.
Brommer B, He M, Zhang Z, Yang Z, Page JC, Su J, Zhang Y, Zhu J, Gouy E, Tang J, Williams P, Dai W, Wang Q, Solinsky R, Chen B, He Z. Improving hindlimb locomotor function by Non-invasive AAV-mediated manipulations of propriospinal neurons in mice with complete spinal cord injury. Nat Commun. 2021 Feb 3;12(1):781. doi: 10.1038/s41467-021-20980-4. PMID: 33536416; PMCID: PMC7859413.
Lee SJ, Lodder B, Chen Y, Patriarchi T, Tian L, Sabatini BL. Cell-type-specific asynchronous modulation of PKA by dopamine in learning. Nature. 2021 Feb;590(7846):451-456. doi: 10.1038/s41586-020-03050-5. Epub 2020 Dec 23. PMID: 33361810; PMCID: PMC7889726.
Yap EL, Pettit NL, Davis CP, Nagy MA, Harmin DA, Golden E, Dagliyan O, Lin C, Rudolph S, Sharma N, Griffith EC, Harvey CD, Greenberg ME. Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Nature. 2021 Feb;590(7844):115-121. doi: 10.1038/s41586-020-3031-0. Epub 2020 Dec 9. PMID: 33299180; PMCID: PMC7864877.
Zhang C, Kaye JA, Cai Z, Wang Y, Prescott SL, Liberles SD. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021 Feb 3;109(3):461-472.e5. doi: 10.1016/j.neuron.2020.11.010. Epub 2020 Dec 4. PMID: 33278342; PMCID: PMC7864887.
Taiber S, Cohen R, Yizhar-Barnea O, Sprinzak D, Holt JR, Avraham KB. Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness. EMBO Mol Med. 2021 Feb 5;13(2):e13259. doi: 10.15252/emmm.202013259. Epub 2020 Dec 22. PMID: 33350593; PMCID: PMC7863404.
2020
Cui J, Shipley FB, Shannon ML, Alturkistani O, Dani N, Webb MD, Sugden AU, Andermann ML, Lehtinen MK. Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation. Dev Cell. 2020 Dec 7;55(5):617-628.e6. doi: 10.1016/j.devcel.2020.09.020. Epub 2020 Oct 9. PMID: 33038331; PMCID: PMC7725967.
Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA. Reprogramming to recover youthful epigenetic information and restore vision. Nature. 2020 Dec;588(7836):124-129. doi: 10.1038/s41586-020-2975-4. Epub 2020 Dec 2. PMID: 33268865; PMCID: PMC7752134.
Li Y, He X, Kawaguchi R, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich PG, Geschwind DH, He Z. Microglia-organized scar-free spinal cord repair in neonatal mice. Nature. 2020 Nov;587(7835):613-618. doi: 10.1038/s41586-020-2795-6. Epub 2020 Oct 7. PMID: 33029008; PMCID: PMC7704837.
Lee J, Wang W, Sabatini BL. Anatomically segregated basal ganglia pathways allow parallel behavioral modulation. Nat Neurosci. 2020 Nov;23(11):1388-1398. doi: 10.1038/s41593-020-00712-5. Epub 2020 Sep 28. PMID: 32989293; PMCID: PMC7606600.
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3. Cell Metab. 2020 Oct 6;32(4):665-675.e6. doi: 10.1016/j.cmet.2020.08.016. Epub 2020 Sep 16. PMID: 32941798; PMCID: PMC7543662.
Liang L, Fratzl A, Reggiani JDS, El Mansour O, Chen C, Andermann ML. Retinal Inputs to the Thalamus Are Selectively Gated by Arousal. Curr Biol. 2020 Oct 19;30(20):3923-3934.e9. doi: 10.1016/j.cub.2020.07.065. Epub 2020 Aug 13. PMID: 32795442; PMCID: PMC7665906.
Chantranupong L, Saulnier JL, Wang W, Jones DR, Pacold ME, Sabatini BL. Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain. Elife. 2020 Oct 12;9:e59699. doi: 10.7554/eLife.59699. PMID: 33043885; PMCID: PMC7575323.
Lee J, Nist-Lund C, Solanes P, Goldberg H, Wu J, Pan B, Schneider BL, Holt JR. Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B. Hear Res. 2020 Sep 1;394:107882. doi: 10.1016/j.heares.2020.107882. Epub 2020 Jan 13. PMID: 31980281.
Li Y, Lopez-Huerta VG, Adiconis X, Levandowski K, Choi S, Simmons SK, Arias-Garcia MA, Guo B, Yao AY, Blosser TR, Wimmer RD, Aida T, Atamian A, Naik T, Sun X, Bi D, Malhotra D, Hession CC, Shema R, Gomes M, Li T, Hwang E, Krol A, Kowalczyk M, Peça J, Pan G, Halassa MM, Levin JZ, Fu Z, Feng G. Distinct subnetworks of the thalamic reticular nucleus. Nature. 2020 Jul;583(7818):819-824. doi: 10.1038/s41586-020-2504-5. Epub 2020 Jul 22. PMID: 32699411; PMCID: PMC7394718.
Gong X, Mendoza-Halliday D, Ting JT, Kaiser T, Sun X, Bastos AM, Wimmer RD, Guo B, Chen Q, Zhou Y, Pruner M, Wu CW, Park D, Deisseroth K, Barak B, Boyden ES, Miller EK, Halassa MM, Fu Z, Bi G, Desimone R, Feng G. An Ultra-Sensitive Step-Function Opsin for Minimally Invasive Optogenetic Stimulation in Mice and Macaques. Neuron. 2020 Jul 8;107(1):197. doi: 10.1016/j.neuron.2020.06.018.
Hrvatin S, Sun S, Wilcox OF, Yao H, Lavin-Peter AJ, Cicconet M, Assad EG, Palmer ME, Aronson S, Banks AS, Griffith EC, Greenberg ME. Neurons that regulate mouse torpor. Nature. 2020 Jul;583(7814):115-121. doi: 10.1038/s41586-020-2387-5. Epub 2020 Jun 11. PMID: 32528180; PMCID: PMC7449701.
Granger AJ, Wang W, Robertson K, El-Rifai M, Zanello AF, Bistrong K, Saunders A, Chow BW, Nuñez V, Turrero García M, Harwell CC, Gu C, Sabatini BL. Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner. Elife. 2020 Jul 2;9:e57749. doi: 10.7554/eLife.57749. PMID: 32613945; PMCID: PMC7360370.
Prescott SL, Umans BD, Williams EK, Brust RD, Liberles SD. An Airway Protection Program Revealed by Sweeping Genetic Control of Vagal Afferents. Cell. 2020 Apr 30;181(3):574-589.e14. doi: 10.1016/j.cell.2020.03.004. Epub 2020 Apr 6. PMID: 32259485; PMCID: PMC7197391.
Hu B, Jin C, Zeng X, Resch JM, Jedrychowski MP, Yang Z, Desai BN, Banks AS, Lowell BB, Mathis D, Spiegelman BM. γδ T cells and adipocyte IL-17RC control fat innervation and thermogenesis. Nature. 2020 Feb;578(7796):610-614. doi: 10.1038/s41586-020-2028-z. Epub 2020 Feb 19. PMID: 32076265; PMCID: PMC7055484.
Zhang Y, Li H, Min YL, Sanchez-Ortiz E, Huang J, Mireault AA, Shelton JM, Kim J, Mammen PPA, Bassel-Duby R, Olson EN. Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system. Sci Adv. 2020 Feb 19;6(8):eaay6812. doi: 10.1126/sciadv.aay6812. PMID: 32128412; PMCID: PMC7030925.
2019
Perry RJ, Resch JM, Douglass AM, Madara JC, Rabin-Court A, Kucukdereli H, Wu C, Song JD, Lowell BB, Shulman GI. Leptin's hunger-suppressing effects are mediated by the hypothalamic-pituitary-adrenocortical axis in rodents. Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13670-13679. doi: 10.1073/pnas.1901795116. Epub 2019 Jun 18. PMID: 31213533; PMCID: PMC6613139.
Zhang Y, Williams PR, Jacobi A, Wang C, Goel A, Hirano AA, Brecha NC, Kerschensteiner D, He Z. Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs. Neuron. 2019 Jul 3;103(1):39-51.e5.
Zhang Q, Lee WA, Paul DL, Ginty DD. Multiplexed peroxidase-based electron microscopy labeling enables simultaneous visualization of multiple cell types. Nat Neurosci. 2019 May;22(5):828-839.
Sharma N, Pollina EA, Nagy MA, Yap EL, DiBiase FA, Hrvatin S, Hu L, Lin C, Greenberg ME. ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation. Neuron. 2019 Apr 17;102(2):390-406.e9
Zimmerman AL, Kovatsis EM, Pozsgai RY, Tasnim A, Zhang Q, Ginty DD. Neuron. 2019 Apr 17;102(2):420-434.
Mandelbaum G, Taranda J, Haynes TM, Hochbaum DR, Huang KW, Hyun M, Umadevi Venkataraju K, Straub C, Wang W, Robertson K, Osten P, Sabatini BL. Distinct Cortical-Thalamic-Striatal Circuits through the Parafascicular Nucleus. Neuron. 2019 Mar 19. pii: S0896-6273(19)30170-9.
Min YL, Li H, Rodriguez-Caycedo C, Mireault AA, Huang J, Shelton JM, McAnally JR, Amoasii L, Mammen PPA, Bassel-Duby R, Olson EN. CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells. Sci Adv. 2019 Mar 6;5(3):eaav4324.
Chettih SN, Harvey CD. Single-neuron perturbations reveal feature-specific competition in V1. Nature. 2019 Mar;567(7748):334-340.
Nist-Lund CA, Pan B, Patterson A, Asai Y, Chen T, Zhou W, Zhu H, Romero S, Resnik J, Polley DB, Géléoc GS, Holt JR. Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders. Nat Commun. 2019 Jan 22;10(1):236.
Korecka JA, Talbot S, Osborn TM, de Leeuw SM, Levy SA, Ferrari EJ, Moskites A, Atkinson E, Jodelka FM, Hinrich AJ, Hastings ML, Woolf CJ, Hallett PJ, Isacson O. Neurite Collapse and Altered ER Ca(2+) Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation. Stem Cell Reports. 2019 Jan 8;12(1):29-41.
Huang T, Lin SH, Malewicz NM, Zhang Y, Zhang Y, Goulding M, LaMotte RH, Ma Q. Identifying the pathways required for coping behaviours associated with sustained pain. Nature. 2019 Jan;565(7737):86-90.
2018
Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, Kersten S, Zhang K, Qi L.Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. EMBO J. 2018 Nov 15;37(22).
Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. Nat Commun. 2018 Oct 2;9(1):4044.
Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z. Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature. 2018 Sep;561(7724):547-550.
Pan B, Akyuz N, Liu XP, Asai Y, Nist-Lund C, Kurima K, Derfler BH, György B, Limapichat W, Walujkar S, Wimalasena LN, Sotomayor M, Corey DP, Holt JR. TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron. 2018 Aug 22;99(4):736-753.e6.
Chen B, Li Y, Yu B, Zhang Z, Brommer B, Williams PR, Liu Y, Hegarty SV, Zhou S, Zhu J, Guo H, Lu Y, Zhang Y, Gu X, He Z. Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell. 2018 Jul 26;174(3):521-535.
Tao R, Wang C, Stöhr O, Qiu W, Hu Y, Miao J, Dong XC, Leng S, Stefater M, Stylopoulos N, Lin L, Copps KD, White MF. Inactivating hepatic follistatin alleviates hyperglycemia. Nat Med. 2018 Jul;24(7):1058-1069.
Liang L, Fratzl A, Goldey G, Ramesh RN, Sugden AU, Morgan JL, Chen C, Andermann ML. A Fine-Scale Functional Logic to Convergence from Retina to Thalamus. Cell. 2018 May 31;173(6):1343-1355.
Liu J, Reggiani JDS, Laboulaye MA, Pandey S, Chen B, Rubenstein JLR, Krishnaswamy A, Sanes JR. Tbr1 instructs laminar patterning of retinal ganglion cell dendrites. Nat Neurosci. 2018 May;21(5):659-670.
Xu J, Bartolome CL, Low CS, Yi X, Chien CH, Wang P, Kong D. Genetic identification of leptin neural circuits in energy and glucose homeostases.Nature. 2018 Apr;556(7702):505-509.
Martínez-François JR, Fernández-Agüera MC, Nathwani N, Lahmann C, Burnham VL, Danial NN, Yellen G. BAD and K(ATP) channels regulate neuron excitability and epileptiform activity. Elife. 2018 Jan 25;7.
Masia R, McCarty WJ, Lahmann C, Luther J, Chung RT, Yarmush ML, Yellen G. Live cell imaging of cytosolic NADH/NAD(+) ratio in hepatocytes and liver slices. Am J Physiol Gastrointest Liver Physiol. 2018 Jan 1;314(1):G97-G108.
2017
Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017 Dec;113:16-25.
Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z. Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills. Cell. 2017 Oct 5;171(2):440-455.
Peng YR, Tran NM, Krishnaswamy A, Kostadinov D, Martersteck EM, Sanes JR. Satb1 Regulates Contactin 5 to Pattern Dendrites of a Mammalian Retinal Ganglion Cell. Neuron. 2017 Aug 16;95(4):869-883.
Díaz-García CM, Mongeon R, Lahmann C, Koveal D, Zucker H, Yellen G. Neuronal Stimulation Triggers Neuronal Glycolysis and Not Lactate Uptake. Cell Metab. 2017 Aug 1;26(2):361-374.
Liu Y, Wang X, Li W, Zhang Q, Li Y, Zhang Z, Zhu J, Chen B, Williams PR, Zhang Y, Yu B, Gu X, He Z. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions. Neuron. 2017 Aug 16;95(4):817-833.
Gu Z, Kalambogias J, Yoshioka S, Han W, Li Z, Kawasawa YI, Pochareddy S, Li Z, Liu F, Xu X, Wijeratne HRS, Ueno M, Blatz E, Salomone J, Kumanogoh A, Rasin MR, Gebelein B, Weirauch MT, Sestan N, Martin JH, Yoshida Y. Control of species-dependent cortico-motoneuronal connections underlying manual dexterity. Science. 2017 Jul 28;357(6349):400-404.
Livneh Y, Ramesh RN, Burgess CR, Levandowski KM, Madara JC, Fenselau H, Goldey GJ, Diaz VE, Jikomes N, Resch JM, Lowell BB, Andermann ML. Homeostatic circuits selectively gate food cue responses in insular cortex. Nature. 2017 Jun 29;546(7660):611-616.
Norsworthy MW, Bei F, Kawaguchi R, Wang Q, Tran NM, Li Y, Brommer B, Zhang Y, Wang C, Sanes JR, Coppola G, He Z. Sox11 Expression Promotes Regeneration of Some Retinal Ganglion Cell Types but Kills Others. Neuron. 2017 Jun 21;94(6):1112-1120.
Wallace ML, Saunders A, Huang KW, Philson AC, Goldman M, Macosko EZ, McCarroll SA, Sabatini BL. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017 Apr 5;94(1):138-152.
Krishnan V, Stoppel DC, Nong Y, Johnson MA, Nadler MJ, Ozkaynak E, Teng BL, Nagakura I, Mohammad F, Silva MA, Peterson S, Cruz TJ, Kasper EM, Arnaout R, Anderson MP. Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature. 2017 Mar 23;543(7646):507-512.
Pan B, Askew C, Galvin A, Heman-Ackah S, Asai Y, Indzhykulian AA, Jodelka FM, Hastings ML, Lentz JJ, Vandenberghe LH, Holt JR, Géléoc GS. Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nat Biotechnol. 2017 Mar;35(3):264-272.
2016
Cartoni R, Norsworthy MW, Bei F, Wang C, Li S, Zhang Y, Gabel CV, Schwarz TL, He Z. The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. Neuron. 2016 Dec 21;92(6):1294-1307.
Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 Jul 6;91(1):25-33.
Wertz MH, Winden K, Neveu P, Ng SY, Ercan E, Sahin M. Cell-type-specific miR-431 dysregulation in a motor neuron model of spinal muscular atrophy. Hum Mol Genet. 2016 Jun 1;25(11):2168-2181.
Yin H, Song CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi MF, Walsh S, Bogorad RL, Gao G, Weng Z, Dong Y, Koteliansky V, Wolfe SA, Langer R, Xue W, Anderson DG. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nat Biotechnol. 2016 Mar;34(3):328-33.
Long C, Amoasii L, Mireault AA, McAnally JR, Li H, Sanchez-Ortiz E, Bhattacharyya S, Shelton JM, Bassel-Duby R, Olson EN. Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy. Science. 2016 Jan 22;351(6271):400-3.
Jackman SL, Turecek J, Belinsky JE, Regehr WG. The calcium sensor synaptotagmin 7 is required for synaptic facilitation. Nature. 2016 Jan 7;529(7584):88-91.
Bei F, Lee HH, Liu X, Gunner G, Jin H, Ma L, Wang C, Hou L, Hensch TK, Frank E, Sanes JR, Chen C, Fagiolini M, He Z. Restoration of Visual Function by Enhancing Conduction in Regenerated Axons. Cell. 2016 Jan 14;164(1-2):219-32.
2015
Jin D, Liu Y, Sun F, Wang X, Liu X, He Z. Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3. Nat Commun. 2015 Nov 24;6:8074.
Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron. 2015 Nov 18;88(4):704-19.
Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015 Sep;18(9):1334-41.
Askew C, Rochat C, Pan B, Asai Y, Ahmed H, Child E, Schneider BL, Aebischer P, Holt JR. Tmc gene therapy restores auditory function in deaf mice. Sci Transl Med. 2015 Jul 8;7(295):295.
Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20;86(4):1000-14
Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shlem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. In vivo genome editing using Staphylococcus aureus Cas9. Nature. 2015 Apr 9;520(7546):186-91.
Duan X, Qiao M, Bei F, Kim IJ, He Z, Sanes JR. Subtype-specific regeneration of retinal ganglion cells following axotomy: effects of osteopontin and mTOR signaling. Neuron. 2015 Mar 18;85(6):1244-56.