Both axons (via growth cones) and blood vessels (via EC tip cells) sense the environment for positive and negative cues, thus determining where they end up. At least four ligands and their receptors, first identified as mediators of axon guidance, have …

  Neuropilin 1 and 2 (NRP1, NRP2) bind both semaphorins (SEMA) and VEGF through their a1a2 and b1b2 extracellular domains, respectively. NRPs mediate axon guidance by forming complexes with plexins and mediate angiogenesis by forming complexes with VEGF …

  Tumor blood vessels have abnormal morphology (McDonald, Nature Medicine 2003) and the EC are aneuploid with multiple chromosomes. The TRAMP model of spontaneous prostate carcinoma is useful for analyzing programmed tumor angiogenesis. TRAMP TEC are stem …

  SEMA/HUVEC Effect of SEMA3F on HUVECs (Joe Italiano) 2.68 MB, 0:09 min QuickTime Player SEMA-induced Repulsion Co-culture of tumor cells expressing SEMA3F and EC expressing NRP2, EC are repelled (Diane Bielenberg) 8.95MB, 0:18 min QuickTime Player SEMA …

  The Klagsbrun Laboratory Vascular Biology Program Boston Children's Hospital Karp Family Research Building, 12th Floor 1 Blackfan Circle Boston, MA 02115 For directions to Boston Children's Hospital and the Karp Family Research Laboratories, click here. …

  This site is intended to provide information for families, physicians, genetic counselors, and researchers who are interested in learning more about our research on the genetics of Interstitial Cystitis (IC), also known as Painful Bladder Syndrome.  …

  The research in our laboratory focuses on three main topics. Our first focus area is the crosstalk between Endoplasmic Reticulum (ER) stress/unfolded protein response (UPR) and insulin receptor signaling systems. The second area is the relation between …

Data sets associated with publications Here you will find data sets associated with our lab's publications. Fame, RM, Kalugin, PN, Petrova, B, Xu, H, Soden, PA, Shipley, FB, Dani, N, Grant, B, Pragana, A, Head, JP, Gupta, S, Shannon, ML, Chifamba, FF, …

Principal Investigator William La Cava, PhD William La Cava directs the Cava Laboratory and is a new faculty member in the Computational Health Informatics Program (CHIP) at Boston Children’s Hospital and Harvard Medical School. He received his PhD from …

PubMed  |  Google Scholar 2022 Human endothelial colony-forming cells Melero-Martin JM Cold Spring Harb Perspect Med  2022; Apr 4:a041154 PDF Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without …